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Head and Neck Pathology
Published in: Head and Neck Pathology 1/2021

01-03-2021 | Neurofibromatosis Type 1 | Special Issue: Pediatric Pathology

Review of Pediatric Head and Neck Neoplasms that Raise the Possibility of a Cancer Predisposition Syndrome

Authors: Nahir Cortes-Santiago, Kalyani Patel

Published in: Head and Neck Pathology | Issue 1/2021

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Abstract

Cancer predisposition syndromes (CPS) are generally heritable conditions that predispose individuals to develop cancer at a higher rate and younger age than their representative general population. They are a significant cause of cancer related morbidity and mortality in the pediatric population. Therefore, recognition of lesions that may be associated with a CPS and alerting the clinicians to its implications is a crucial task for a diagnostic pathologist. In this review we discuss benign pediatric head and neck lesions associated with CPS namely: odontogenic keratocyst, juvenile nasopharyngeal angiofibroma, ossifying fibroma of the jaw, paraganglioma, plexiform neurofibroma, plexiform schwannoma, mucosal neuroma, and nevus sebaceous syndrome; along with malignant tumors such as squamous cell carcinoma. Several head and neck melanocytic, endocrine, and central nervous system tumors can also be associated with CPS; they are beyond the scope of this article. Nasal chondromesenchymal hamartoma is discussed elsewhere in this issue.
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Metadata
Title
Review of Pediatric Head and Neck Neoplasms that Raise the Possibility of a Cancer Predisposition Syndrome
Authors
Nahir Cortes-Santiago
Kalyani Patel
Publication date
01-03-2021
Publisher
Springer US
Published in
Head and Neck Pathology / Issue 1/2021
Electronic ISSN: 1936-0568
DOI
https://doi.org/10.1007/s12105-021-01292-x

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