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European Journal of Nuclear Medicine and Molecular Imaging

Published in:

01-12-2021 | Neuroendocrine Tumor | Original Article

Head-to-head comparison of ⁶⁸Ga-DOTATATE PET/CT and ¹⁸F-FDG PET/CT in localizing tumors with ectopic adrenocorticotropic hormone secretion: a prospective study

Authors: Qingxing Liu, Jie Zang, Yingying Yang, Qing Ling, Huanwen Wu, Pengyan Wang, Lin Lu, Zhaohui Zhu

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 13/2021

Abstract

Purpose

Localizing the source of ectopic adrenocorticotropic hormone secretion (EAS) is challenging. This study compared the diagnostic value of ⁶⁸Ga-DOTATATE PET/CT and ¹⁸F-FDG PET/CT in tumors with EAS.

Methods

Thirty-six patients with a suspicion of EAS were enrolled to undergo both ⁶⁸Ga-DOTATATE PET/CT and ¹⁸F-FDG PET/CT within 4 weeks for comparison. Twenty-three underwent surgical resection or biopsy. Immunohistochemical staining for SSTR2 and Ki-67 was performed to correlate with ⁶⁸Ga-DOTATATE uptake and ¹⁸F-FDG uptake, respectively.

Results

EAS tumors were observed in 20/23 patients. Among the 20 patients with histologically proven EAS tumors, ⁶⁸Ga-DOTATATE PET/CT correctly identified the tumor in 15 (75.0%), with an SUV_max ranging from 1.4 to 20.7 (6.7 ± 5.5). ¹⁸F-FDG PET/CT correctly identified the tumor in 12 (60.0%) patients, with an SUV_max ranging from 1.8 to 10.0 (4.0 ± 2.1). Moreover, ⁶⁸Ga-DOTATATE PET/CT unmasked the sources of EAS in 6 patients with negative ¹⁸F-FDG uptake, and ¹⁸F-FDG PET/CT unmasked the sources in 3 patients with negative ⁶⁸Ga-DOTATATE uptake, resulting in EAS tumors being identified in 18 (90%) patients by combining ⁶⁸Ga-DOTATATE PET/CT and ¹⁸F-FDG PET/CT.

Conclusions

⁶⁸Ga-DOTATATE PET/CT and ¹⁸F-FDG PET/CT are complementary in localizing and discriminating the source of EAS. ⁶⁸Ga-DOTATATE PET/CT combined with ¹⁸F-FDG PET/CT had higher detection rate than each alone.

Trial registration

⁶⁸Ga-DOTATATE PET/CT in Neuroendocrine Tumors (NCT04041882)

URL of registry

https://clinicaltrials.gov/ct2/show/NCT04041882

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Title: Head-to-head comparison of 68Ga-DOTATATE PET/CT and 18F-FDG PET/CT in localizing tumors with ectopic adrenocorticotropic hormone secretion: a prospective study
Authors: Qingxing Liu
Jie Zang
Yingying Yang
Qing Ling
Huanwen Wu
Pengyan Wang
Lin Lu
Zhaohui Zhu
Publication date: 01-12-2021
Publisher: Springer Berlin Heidelberg
Keyword: Neuroendocrine Tumor
Published in: European Journal of Nuclear Medicine and Molecular Imaging / Issue 13/2021
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-021-05370-8

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Head-to-head comparison of ⁶⁸Ga-DOTATATE PET/CT and ¹⁸F-FDG PET/CT in localizing tumors with ectopic adrenocorticotropic hormone secretion: a prospective study

Abstract

Purpose

Methods

Results

Conclusions

Trial registration

URL of registry

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

Trial registration

URL of registry

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