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BMC Neurology
Published in: BMC Neurology 1/2015

Open Access 01-12-2015 | Research Article

Neurocognitive functions and brain atrophy after proven neuroborreliosis: a case-control study

Authors: Holger Schmidt, Marija Djukic, Klaus Jung, Manfred Holzgraefe, Peter Dechent, Nicole von Steinbüchel, Joachim Blocher, Helmut Eiffert, Carsten Schmidt-Samoa

Published in: BMC Neurology | Issue 1/2015

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Abstract

Background

Patients often report neurocognitive difficulties after neuroborreliosis (NB). The frequency and extent of cognitive problems in European patients have been studied incompletely.

Methods

Sixty patients received a neurological and neuropsychological work-up 6 months or longer after treatment for proven NB. Quality of life, psychiatric symptom load, and brain atrophy were measured. All results were compared with a group of 30 healthy control persons adapted for age, gender and education being serologically negative for Borrelia burgdorferi senso latu. A cognitive sum score and a global sum score including cognitive, psychological results and quality of life data was calculated for both groups.

Results

Patients after NB showed a lower (i.e. more impaired) score on the Scripps Neurological rating scale (SNRS), but the observed neurological deficits were generally mild (mean ± SD: 97.1 ± 4.7 vs. 99.1 ± 2.4, p = 0.02). The mean neuropsychological domain results of the NB group were all within the normal range. However, a lower performance was found for the frontal executive function z-values (mean ± SD –0.29 ± 0.60 vs. 0.09 ± 0.60; p = 0.0059) of NB patients. Comparing the global sum score (mean ± SD 11.3 ± 4.2 NB vs. 14.3 ± 2.9 control , p = 0.001) and the cognitive sum score of the NB group with those of the control group (mean ± SD -0.15 ± 0.42 NB vs. 0.08 ± 0.31 control , p = 0.0079), both differences were statistically different. The frequencies of impaired global sum scores and those of the pathological cognitive sum scores (p = 0.07) did not differ statistically. No significant differences were found for health-related quality of life (hrQoL), sleep, psychiatric symptom load, or brain atrophy.

Conclusion

The mean cognitive functions of patients after proven NB were in the normal range. However, we were able to demonstrate a lower performance for the domain of frontal executive functions, for the mean cognitive sum score and the global sum score as a sign of subtle but measurable sequelae of neuroborreliosis. Brain atrophy is not a common consequence of neuroborreliosis.
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Metadata
Title
Neurocognitive functions and brain atrophy after proven neuroborreliosis: a case-control study
Authors
Holger Schmidt
Marija Djukic
Klaus Jung
Manfred Holzgraefe
Peter Dechent
Nicole von Steinbüchel
Joachim Blocher
Helmut Eiffert
Carsten Schmidt-Samoa
Publication date
01-12-2015
Publisher
BioMed Central
Published in
BMC Neurology / Issue 1/2015
Electronic ISSN: 1471-2377
DOI
https://doi.org/10.1186/s12883-015-0386-1

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