Published in:
01-10-2014
Neurocognitive functioning in a Romanian cohort of young adults with parenterally-acquired HIV-infection during childhood
Authors:
Luminita Ene, Donald R. Franklin, Ruxandra Burlacu, Anca E. Luca, Andreea G. Blaglosov, Ronald J. Ellis, Terry J. Alexander, Anya Umlauf, Igor Grant, Dan C. Duiculescu, Cristian L. Achim, Thomas D. Marcotte
Published in:
Journal of NeuroVirology
|
Issue 5/2014
Login to get access
Abstract
The Romanian cohort can provide valuable information about the effect of chronic HIV-infection and exposure to combined antiretroviral therapy (cART) on the developing brain, based on its unique characteristics: young adults infected parenterally with HIV clade F in the late 1980s and exposed to cART for a decade. We conducted a prospective study using a neuropsychological test battery validated in other international HIV cohorts, in order to evaluate the rate and severity of neurocognitive impairment in a group of young Romanian adults. The 49 HIV-infected (HIV+) participants and the 20 HIV negative (HIV−) controls were similar for age and gender, although the HIV− group tended to be more educated. We found higher cognitive impairment prevalence in the HIV+ group (59.1 %) versus the HIV− group (10 %), and the impairment rate remained significantly higher even when the groups were matched based on the educational level (38.7 % for the HIV+ group vs. 10.0 % for the HIV− controls; p = 0.025). The nadir CD4 count was <200 in 71.4 % of patients, but at the time of neurocognitive assessment, 89.5 % of patients had normal immunological status and 81.8 % undetectable HIV load. Among the HIV-impaired group, 26 % of the participants had syndromic impairment while the other 74 % had asymptomatic neurocognitive impairment. We found a high prevalence of neurocognitive dysfunction in the Romanian young adults growing-up with HIV. The greatest HIV-related cognitive deficits were in the domains of executive and motor functioning, consistent with a frontosubcortical pattern.