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Published in: Journal of Neuro-Oncology 3/2013

01-07-2013 | Clinical Study

Neurocognitive functioning and health-related quality of life in patients with radiologically suspected meningiomas

Authors: D. van Nieuwenhuizen, N. Ambachtsheer, J. J. Heimans, J. C. Reijneveld, S. M. Peerdeman, M. Klein

Published in: Journal of Neuro-Oncology | Issue 3/2013

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Abstract

Few data are available concerning the neurocognitive outcome and health-related quality of life (HRQOL) following neurosurgery in meningioma patients, and even less is known about neurocognitive functioning and HRQOL in untreated patients with stable lesions. The present study aims at quantifying the nature and extent of neurocognitive deficits and HRQOL in suspected WHO grade I meningioma patients who have not received surgery and/or radiotherapy and compare outcome to that of healthy controls. Neurocognitive functioning was assessed by using a standardized test battery in 21 radiologically suspected WHO grade I meningioma patients with a wait-and-scan approach. HRQOL was assessed with the MOS SF-36 questionnaire. These patients were matched for age, sex, and education with 21 healthy controls. Associations between neurocognitive functioning on the one hand and HRQOL and tumor characteristics on the other were determined. Compared to healthy controls, meningioma patients had lower psychomotor speed (p = 0.011) and working memory capacity (p = 0.034) and furthermore attained lower levels of self-perceived general health and vitality. Neurocognitive functioning in untreated patients was not related to tumor volume, edema or tumor lateralization. No correlations were found between psychomotor speed or working memory and HRQOL. Untreated meningioma patients with stable lesions have limitations in neurocognitive functioning and HRQOL. In deciding upon a treatment strategy these reductions in functioning should be taken into consideration and communicated with the patient.
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Metadata
Title
Neurocognitive functioning and health-related quality of life in patients with radiologically suspected meningiomas
Authors
D. van Nieuwenhuizen
N. Ambachtsheer
J. J. Heimans
J. C. Reijneveld
S. M. Peerdeman
M. Klein
Publication date
01-07-2013
Publisher
Springer US
Published in
Journal of Neuro-Oncology / Issue 3/2013
Print ISSN: 0167-594X
Electronic ISSN: 1573-7373
DOI
https://doi.org/10.1007/s11060-013-1132-4

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