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BMC Public Health
Published in: BMC Public Health 1/2024

Open Access 01-12-2024 | Sarcopenia | Systematic Review

Network meta-analysis of the intervention effects of different exercise measures on Sarcopenia in cancer patients

Authors: Rui Liu, XY Gao, Li Wang

Published in: BMC Public Health | Issue 1/2024

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Abstract

Purpose

This study aims to investigate the impact of four exercise modes (aerobic exercise, resistance exercise, aerobic combined with resistance multimodal exercise, and stretching) on the physical performance of cancer patients.

Methods

Randomized controlled trials (RCTs) were exclusively collected from PubMed, EMBASE, Web of Science, and The Cochrane Library, with a search deadline of April 30, 2023. Different exercise interventions on the physical performance of cancer patients were studied, and the Cochrane risk of bias assessment tool was employed to evaluate the quality of the included literature. Data analysis was conducted using STATA 15.1 software.

Results

This study included ten randomized controlled trials with a combined sample size of 503 participants. Network meta-analysis results revealed that aerobic combined with resistance multimodal exercise could reduce fat mass in cancer patients (SUCRA: 92.3%). Resistance exercise could improve lean mass in cancer patients (SUCRA: 95.7%). Furthermore, resistance exercise could enhance leg extension functionality in cancer patients with sarcopenia (SUCRA: 83.0%).

Conclusion

This study suggests that resistance exercise may be more beneficial for cancer-related sarcopenia.In clinical practice, exercise interventions should be tailored to the individual patients’ circumstances.

Registration number

This review was registered on INPLASY2023110025; DOI number is https://​doi.​org/​10.​37766/​inplasy2023.​11.​0025 .
Literature
1.
Kim JW, Kim R, Choi H, Lee SJ, Bae GU. Understanding of Sarcopenia: from definition to therapeutic strategies. Arch Pharm Res. 2021;44:876–89.CrossRefPubMed
2.
Liguori I, Russo G, Aran L, Bulli G, Curcio F, Della-Morte D, et al. Sarcopenia: assessment of disease burden and strategies to improve outcomes. Clin Interv Aging. 2018;13:913–27.CrossRefPubMedPubMedCentral
3.
Delmonico MJ, Harris TB, Visser M, Park SW, Conroy MB, Velasquez-Mieyer P, et al. Longitudinal study of muscle strength, quality, and adipose tissue infiltration. Am J Clin Nutr. 2009;90:1579–85.CrossRefPubMedPubMedCentral
4.
Couderc AL, Liuu E, Boudou-Rouquette P, Poisson J, Frelaut M, Montégut C et al. Pre-therapeutic Sarcopenia among Cancer patients: an Up-to-date Meta-analysis of Prevalence and Predictive Value during Cancer Treatment. Nutrients. 2023;15.
5.
Halvorsen TO, Valan CD, Slaaen M, Grønberg BH. Associations between muscle measures, survival, and toxicity in patients with limited stage small cell lung cancer. J Cachexia Sarcopenia Muscle. 2020;11:1283–90.CrossRefPubMedPubMedCentral
6.
Feliciano EMC, Kroenke CH, Meyerhardt JA, Prado CM, Bradshaw PT, Kwan ML, et al. Association of Systemic Inflammation and Sarcopenia with Survival in Nonmetastatic Colorectal Cancer: results from the C SCANS study. JAMA Oncol. 2017;3:e172319.CrossRefPubMed
7.
Ryan AM, Prado CM, Sullivan ES, Power DG, Daly LE. Effects of weight loss and sarcopenia on response to chemotherapy, quality of life, and survival. Nutrition. 2019;67–68:110539.CrossRefPubMed
8.
Yoshimura Y, Wakabayashi H, Yamada M, Kim H, Harada A, Arai H. Interventions for treating Sarcopenia: a systematic review and Meta-analysis of Randomized Controlled studies. J Am Med Dir Assoc. 2017;18:e5531–16.CrossRef
9.
Koya S, Kawaguchi T, Hashida R, Hirota K, Bekki M, Goto E, et al. Effects of in-hospital exercise on Sarcopenia in hepatoma patients who underwent transcatheter arterial chemoembolization. J Gastroenterol Hepatol. 2019;34:580–8.CrossRefPubMed
10.
Mahalakshmi B, Maurya N, Lee SD, Bharath Kumar V. Possible neuroprotective mechanisms of Physical Exercise in Neurodegeneration. Int J Mol Sci. 2020;21.
11.
Winzer BM, Paratz JD, Whitehead JP, Whiteman DC, Reeves MM. The feasibility of an exercise intervention in males at risk of oesophageal adenocarcinoma: a randomized controlled trial. PLoS ONE. 2015;10:e0117922.CrossRefPubMedPubMedCentral
12.
Rouse B, Chaimani A, Li T. Network meta-analysis: an introduction for clinicians. Intern Emerg Med. 2017;12:103–11.CrossRefPubMed
13.
Higgins JP, Altman DG, Gøtzsche PC, Jüni P, Moher D, Oxman AD, et al. The Cochrane collaboration’s tool for assessing risk of bias in randomised trials. BMJ. 2011;343:d5928.CrossRefPubMedPubMedCentral
14.
Yin Y, Wang J, Yu Z, Zhou L, Liu X, Cai H, et al. Does whole-body vibration training have a positive effect on balance and walking function in patients with stroke? A meta-analysis. Front Hum Neurosci. 2022;16:1076665.CrossRefPubMed
15.
16.
van Valkenhoef G, Dias S, Ades AE, Welton NJ. Automated generation of node-splitting models for assessment of inconsistency in network meta-analysis. Res Synth Methods. 2016;7:80–93.CrossRefPubMed
17.
18.
Lam T, McLean M, Hayden A, Poljak A, Cheema B, Gurney H, et al. A potent liver-mediated mechanism for loss of muscle mass during androgen deprivation therapy. Endocr Connect. 2019;8:605–15.CrossRefPubMedPubMedCentral
19.
Dieli-Conwright CM, Courneya KS, Demark-Wahnefried W, Sami N, Lee K, Sweeney FC, et al. Aerobic and resistance exercise improves physical fitness, bone health, and quality of life in overweight and obese breast cancer survivors: a randomized controlled trial. Breast Cancer Res. 2018;20:124.CrossRefPubMedPubMedCentral
20.
Lam T, Cheema B, Hayden A, Lord SR, Gurney H, Gounden S, et al. Androgen deprivation in prostate cancer: benefits of home-based resistance training. Sports Med Open. 2020;6:59.CrossRefPubMedPubMedCentral
21.
Galvão DA, Taaffe DR, Spry N, Joseph D, Newton RU. Combined resistance and aerobic exercise program reverses muscle loss in men undergoing androgen suppression therapy for prostate cancer without bone metastases: a randomized controlled trial. J Clin Oncol. 2010;28:340–7.CrossRefPubMed
22.
Dawson JK, Dorff TB, Tuzon C, Rice JC, Schroeder ET, Lane CJ, et al. Effect of Periodized Resistance training on skeletal muscle during androgen deprivation therapy for prostate Cancer: a pilot randomized Trial. Integr Cancer Ther. 2021;20:15347354211035442.CrossRefPubMedPubMedCentral
23.
Uth J, Hornstrup T, Christensen JF, Christensen KB, Jørgensen NR, Schmidt JF, et al. Efficacy of recreational football on bone health, body composition, and physical functioning in men with prostate cancer undergoing androgen deprivation therapy: 32-week follow-up of the FC prostate randomised controlled trial. Osteoporos Int. 2016;27:1507–18.CrossRefPubMed
24.
Dieli-Conwright CM, Sweeney FC, Courneya KS, Tripathy D, Sami N, Lee K, et al. Hispanic ethnicity as a moderator of the effects of aerobic and resistance exercise in survivors of breast cancer. Cancer. 2019;125:910–20.CrossRefPubMed
25.
Taaffe DR, Galvão DA, Spry N, Joseph D, Chambers SK, Gardiner RA, et al. Immediate versus delayed exercise in men initiating androgen deprivation: effects on bone density and soft tissue composition. BJU Int. 2019;123:261–9.CrossRefPubMed
26.
Grote M, Maihöfer C, Weigl M, Davies-Knorr P, Belka C. Progressive resistance training in cachectic head and neck cancer patients undergoing radiotherapy: a randomized controlled pilot feasibility trial. Radiat Oncol. 2018;13:215.CrossRefPubMedPubMedCentral
27.
28.
Lam T, Birzniece V, McLean M, Gurney H, Hayden A, Cheema BS. The adverse effects of Androgen deprivation therapy in prostate Cancer and the benefits and potential anti-oncogenic mechanisms of Progressive Resistance Training. Sports Med Open. 2020;6:13.CrossRefPubMedPubMedCentral
29.
Rock CL, Thomson CA, Sullivan KR, Howe CL, Kushi LH, Caan BJ, et al. American Cancer Society nutrition and physical activity guideline for cancer survivors. CA Cancer J Clin. 2022;72:230–62.CrossRefPubMed
30.
31.
Evans WJ, Hellerstein M, Orwoll E, Cummings S, Cawthon PM. D(3) -Creatine dilution and the importance of accuracy in the assessment of skeletal muscle mass. J Cachexia Sarcopenia Muscle. 2019;10:14–21.CrossRefPubMedPubMedCentral
32.
33.
Kamel HK. Sarcopenia and Aging Nutrition Reviews. 2003;61:157– 67.
34.
Dickinson JM, Volpi E, Rasmussen BB. Exercise and nutrition to target protein synthesis impairments in aging skeletal muscle. Exerc Sport Sci Rev. 2013;41:216–23.CrossRefPubMedPubMedCentral
35.
Borges IBP, de Oliveira DS, Marie SKN, Lenario AM, Oba-Shinjo SM, Shinjo SK. Exercise Training attenuates ubiquitin-proteasome pathway and increases the genes related to Autophagy on the skeletal muscle of patients with inflammatory myopathies. J Clin Rheumatol. 2021;27:S224–31.CrossRefPubMed
36.
Baar K, Wende AR, Jones TE, Marison M, Nolte LA, Chen M, et al. Adaptations of skeletal muscle to exercise: rapid increase in the transcriptional coactivator PGC-1. Faseb j. 2002;16:1879–86.CrossRefPubMed
37.
Pascual-Fernández J, Fernández-Montero A, Córdova-Martínez A, Pastor D, Martínez-Rodríguez A, Roche E. Sarcopenia: Molecular pathways and potential targets for intervention. Int J Mol Sci. 2020;21.
38.
Emerson NS, Stout JR, Fukuda DH, Robinson EH, Iv, Scanlon TC, et al. Resistance training improves capacity to delay neuromuscular fatigue in older adults. Arch Gerontol Geriatr. 2015;61:27–32.CrossRefPubMed
39.
Kukulka CG, Clamann HP. Comparison of the recruitment and discharge properties of motor units in human brachial biceps and adductor pollicis during isometric contractions. Brain Res. 1981;219:45–55.CrossRefPubMed
40.
Bryanton MA, Carey JP, Kennedy MD, Chiu LZ. Quadriceps effort during squat exercise depends on hip extensor muscle strategy. Sports Biomech. 2015;14:122–38.CrossRefPubMed
41.
Kohrt WM, Bloomfield SA, Little KD, Nelson ME, Yingling VR. American College of Sports Medicine Position stand: physical activity and bone health. Med Sci Sports Exerc. 2004;36:1985–96.CrossRefPubMed
Metadata
Title
Network meta-analysis of the intervention effects of different exercise measures on Sarcopenia in cancer patients
Authors
Rui Liu
XY Gao
Li Wang
Publication date
01-12-2024
Publisher
BioMed Central
Keyword
Sarcopenia
Published in
BMC Public Health / Issue 1/2024
Electronic ISSN: 1471-2458
DOI
https://doi.org/10.1186/s12889-024-18493-y

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