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01-03-2015 | Original Paper

Network-based gene expression analysis of vascular wall of juvenile Moyamoya disease

Authors: Nobuya Okami, Yasuo Aihara, Hiroyuki Akagawa, Koji Yamaguchi, Akitsugu Kawashima, Toshiyuki Yamamoto, Yoshikazu Okada

Published in: Child's Nervous System | Issue 3/2015

Abstract

Subjects

Little is known about the pathology and pathogenesis of the Moyamoya disease (MMD). To better understand the molecular processes involved in MMD gene expression analysis of Moyamoya artery tissue to a control artery, this study was conducted.

Methods

Tissue samples of two MMD and two non-MMD were profiled using oligonucleotide microarrays. Gene ontology classification of the differentially expressed genes was analyzed, and regulatory functional networks and pathways were identified with a network-based computational pathway analysis tool. Analysis of MMD and control tissue revealed 104 differentially expressed genes.

Results

The two major significantly associated gene ontology terms was cellular development and cellular movement. Further network-based analysis showed significant interaction between RNF213 downstream gene networks and the top 3 score gene networks of MMD. Three major nodes of this network were evident in the merged network and were showing interactions with downstream network of RNF213.

Conclusions

Our results demonstrate that cellular development and cellular movement in MMD are the key role of mechanisms.

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Title: Network-based gene expression analysis of vascular wall of juvenile Moyamoya disease
Authors: Nobuya Okami
Yasuo Aihara
Hiroyuki Akagawa
Koji Yamaguchi
Akitsugu Kawashima
Toshiyuki Yamamoto
Yoshikazu Okada
Publication date: 01-03-2015
Publisher: Springer Berlin Heidelberg
Published in: Child's Nervous System / Issue 3/2015
Print ISSN: 0256-7040
Electronic ISSN: 1433-0350
DOI: https://doi.org/10.1007/s00381-014-2605-2

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Network-based gene expression analysis of vascular wall of juvenile Moyamoya disease

Abstract

Subjects

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Subjects

Methods

Results

Conclusions

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