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04-05-2023 | Nephrotic Syndrome | Original Article

The association of low birthweight and prematurity on outcomes in children and adults with nephrotic syndrome—a NEPTUNE cohort study

Authors: Sangeeta Hingorani, Keisha L. Gibson, Yuping Xie, Yujie Wang, Sean Eddy, John Hartman, Matthew Sampson, Clarissa Cassol, David Thomas, Debbie S. Gipson, Howard Trachtman, Tarak Srivastava, Kimberly Reidy, on behalf of the NEPTUNE Pediatric Working Group

Published in: Pediatric Nephrology | Issue 10/2023

Abstract

Background

In single-center studies, both preterm birth and low birth weight (LBW) are associated with worse outcomes in childhood nephrotic syndrome. Using the Nephrotic Syndrome Study Network (NEPTUNE) observational cohort, we tested the hypothesis that in patients with nephrotic syndrome, hypertension, proteinuria status, and disease progression would be more prevalent and more severe in subjects with LBW and prematurity singly or in combination (LBW/prematurity).

Methods

Three hundred fifty-nine adults and children with focal segmental glomerulosclerosis (FSGS) or minimal change disease (MCD) and available birth history were included. Estimated glomerular filtration rate (eGFR) decline and remission status were primary outcomes, and secondary outcomes were kidney histopathology, kidney gene expression, and urinary biomarkers. Logistic regression was used to identify associations with LBW/prematurity and these outcomes.

Results

We did not find an association between LBW/prematurity and remission of proteinuria. However, LBW/prematurity was associated with greater decline in eGFR. This decline in eGFR was partially explained by the association of LBW/prematurity with APOL1 high-risk alleles, but the association remained after adjustment. There were no differences in kidney histopathology or gene expression in the LBW/prematurity group compared to normal birth weight/term birth.

Conclusion

LBW and premature babies who develop nephrotic syndrome have a more rapid decline in kidney function. We did not identify clinical or laboratory features that distinguished the groups. Additional studies in larger groups are needed to fully ascertain the effects of (LBW) and prematurity alone or in combination on kidney function in the setting of nephrotic syndrome.

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Title: The association of low birthweight and prematurity on outcomes in children and adults with nephrotic syndrome—a NEPTUNE cohort study
Authors: Sangeeta Hingorani
Keisha L. Gibson
Yuping Xie
Yujie Wang
Sean Eddy
John Hartman
Matthew Sampson
Clarissa Cassol
David Thomas
Debbie S. Gipson
Howard Trachtman
Tarak Srivastava
Kimberly Reidy
on behalf of the NEPTUNE Pediatric Working Group
Publication date: 04-05-2023
Publisher: Springer Berlin Heidelberg
Keyword: Nephrotic Syndrome
Published in: Pediatric Nephrology / Issue 10/2023
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-023-05876-3

Keynote webinar | Spotlight on medication adherence

Springer Medicine

The association of low birthweight and prematurity on outcomes in children and adults with nephrotic syndrome—a NEPTUNE cohort study

Abstract

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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