Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
BMC Urology
Published in: BMC Urology 1/2021

Open Access 01-12-2021 | Nephrostomy | Research

Quantitative evaluation of upper urinary tract pump function in pigs with acute unilateral lower ureteral obstruction by 640-slice dynamic volume CT

Authors: Chongwen Mao, Cong Peng, Song Li, Liling Chen, Mengjing You, Kewei Fang, Shutian Xiang, Yunshan Su

Published in: BMC Urology | Issue 1/2021

Login to get access

Abstract

Background

It is a challenging problem to differentiate obstructive hydronephrosis from noninvasive evaluation of renal pelvis and ureteral motility in patients. The purpose of this study was to explore the value of 640-slice dynamic volume CT (DVCT) in the quantitative measurement of upper urinary tract (UUT) pump function after acute unilateral lower ureteral obstruction in pigs.

Methods

In this study, a perfusion pig model was constructed by constant pressure perfusion testing of the renal pelvis and left nephrostomy. The perfusion and pressure measuring devices were connected to create a state of no obstruction and acute obstruction of the lower part of the left ureter. After successful modelling, continuous dynamic volume scanning of the bilateral renal excretion phase was performed with 640-slice DVCT, and pump functions of the renal pelvis and part of the upper ureter were calculated and analysed. No obstruction or acute obstruction of the lower part of the left ureter was observed. Pump functions of the renal pelvis and part of the upper ureter were determined.

Results

The results showed that after LUUT fistulostomy, the time difference between the average UUT volume and positive volume value increased gradually, and the calculated flow velocity decreased, which was significantly different from that of the RUUT. The volume difference of the LUUT increased significantly in mild obstruction. In the bilateral control, the volume change rate of the LUUT increased with mild obstruction and decreased with severe obstruction, and there was a significant difference between the left and right sides.

Conclusion

The continuous dynamic volume scan and measurement of 640-slice DVCT can obtain five pump function datasets of UUT in pigs with acute lower ureteral obstruction.
Literature
1.
Osman F, Romics I, Nyirady P, Monos E, Nadasy GL. Ureteral motility. Acta Physiol Hung. 2009;96(4):407–26.CrossRef
2.
Kim S, Jacob JS, Kim DC, Rivera R, Lim RP, Lee VS. Time-resolved dynamic contrast-enhanced MR urography for the evaluation of ureteral peristalsis: initial experience. J Magn Resonance Imaging: JMRI. 2008;28(5):1293–8.CrossRef
3.
Rowe CK, Franco FB, Barbosa JA, Minnillo BJ, Chow JS, Treves T, et al. A novel method of evaluating ureteropelvic junction obstruction: dynamic near infrared fluorescence imaging compared to standard modalities to assess urinary obstruction in a swine model. J Urol. 2012;188(5):1978–85.CrossRef
4.
Teodorovich OV, Vasil’ev A, Zabrodina NB, Bochkarev AB, Muchkaeva IB, Sarkhadov N, et al. Informative value of radiodiagnosis methods of pyelo-ureteral strictures in kidney anomaly. Urologiia (Moscow, Russia: 1999). 2010;2:18–21.
5.
Woodbury PW, Mitchell ME, Scheidler DM, Adams MC, Rink RC, McNulty A. Constant pressure perfusion: a method to determine obstruction in the upper urinary tract. J Urol. 1989;142(2 Pt 2):632–5 (discussion 667–638).CrossRef
6.
Farrugia MK, Whitaker RH. The search for the definition, etiology, and effective diagnosis of upper urinary tract obstruction: the Whitaker test then and now. J Pediatric Urol. 2019;15(1):18–26.CrossRef
7.
Pegolo PT, Miranda ML, Kim S, Oliveira Filho AG, Reis LO, Silva JM. Antegrade pressure measurement of urinary tract in children with persistent hydronephrosis. Int Braz J Urol. 2012;38(4):448–55.CrossRef
8.
Deng X, Song L, Xie D, Fan D, Zhu L, Yao L, et al. A novel flexible ureteroscopy with intelligent control of renal pelvic pressure: an initial experience of 93 cases. J Endourol. 2016;30(10):1067–72.CrossRef
9.
Wolin EA, Hartman DS, Olson JR. Nephrographic and pyelographic analysis of CT urography: differential diagnosis. AJR Am J Roentgenol. 2013;200(6):1197–203.CrossRef
10.
Lovasz S, Lovasz L, Nyirady P, Romics I. A novel quantitative method for measuring obstruction in the upper urinary tract: the ‘obstruction coefficient.’ Int J Urol. 2008;15(6):499–504.CrossRef
11.
Zhu X, Song L, Xie D, Peng Z, Guo S, Deng X, et al. Animal experimental study to test application of intelligent pressure control device in monitoring and control of renal pelvic pressure during flexible ureteroscopy. Urology. 2016;91(242):e211-245.
12.
Itoh K, Nonomura K, Matsuno T, Furudate M, Koyanagi T. Radionuclide constant pressure perfusion study on measurement of exit urine flow: experimental and preliminary clinical investigations. J Urol. 1993;150(2 Pt 1):420–6.CrossRef
13.
Soygur T, Burgu B, Zumrutbas A, Suer E. The need for ureteric re-implantation during augmentation cystoplasty: video-urodynamic evaluation. BJU Int. 2010;105(4):530–2.CrossRef
14.
Olsen PR. The renal pelvis and ureteral peristalsis. I. Pelveometry. Scand J Urol Nephrol. 1979;13(3):269–73.CrossRef
15.
Mudraya IS, Khodyreva LA. The role of functional urodynamic disorders in the pathogenesis of urolithiasis. Arch Ital Urol Androl. 2011;83(1):31–6.PubMed
16.
Tillig B, Mutschke O, Rolle U, Gaunitz U, Asmussen G, Constantinou CE. Effects of artificial obstruction on the function of the upper urinary tract of Guinea pigs, rats and pigs. Eur J Pediatric Surg. 2004;14(5):303–15.CrossRef
Metadata
Title
Quantitative evaluation of upper urinary tract pump function in pigs with acute unilateral lower ureteral obstruction by 640-slice dynamic volume CT
Authors
Chongwen Mao
Cong Peng
Song Li
Liling Chen
Mengjing You
Kewei Fang
Shutian Xiang
Yunshan Su
Publication date
01-12-2021
Publisher
BioMed Central
Published in
BMC Urology / Issue 1/2021
Electronic ISSN: 1471-2490
DOI
https://doi.org/10.1186/s12894-021-00887-4

Other articles of this Issue 1/2021

BMC Urology 1/2021 Go to the issue

Research

Clinical significance and risk factors of urethrovesical anastomotic urinary leakage following robot-assisted radical prostatectomy: a multi-institutional study

Case report

A rare case of eosinophilic cystitis involving the inside and outside of the urinary bladder associated with an infected urachal cyst

Research article

Comprehensive analysis of tumour mutational burden and its clinical significance in prostate cancer

Research article

Biofilm reduction potential of 0.02% polyhexanide irrigation solution in several types of urethral catheters

Research article

Do organic substances act as a degradable binding matrix in calcium oxalate kidney stones?

Case report

Cavernous lymphangioma of the urinary bladder in an adult woman: an additional case report of a rare lesion and literature review