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Published in: BMC Urology 1/2020

01-12-2020 | Nephrostomy | Case report

A case report of primary upper urinary tract signet-ring cell carcinoma and literature review

Authors: Zhaohua Ye, Qiwu Mi, Daosheng Luo, Zhixiong Li, Jiexin Luo

Published in: BMC Urology | Issue 1/2020

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Abstract

Background

Upper tract urothelial carcinoma with pure non-urothelial histology is an exception but variants are present in ~ 25% of cases. Primary upper urinary tract signet -ring cell carcinoma is extremely rare.

Case presentation

We report the case of a 65-year-old male diagnosed primary upper urinary tract signet-ring cell carcinoma while underwent percutaneous nephrolithotomy. Radical nephroureterectomy and adjuvant chemotherapy were performed sequentially. The patient is now recovering well with a regular follow-up for more than 1 year.

Conclusions

The upper urinary tract malignancy often appears as a high grade, high stage tumor and has a uniformly poor prognosis, but a timely multimodal management can bring a good outcome.
Literature
3.
go back to reference Olgac S, Mazumdar M, Dalbagni G. Urothelial carcinoma of the renal pelvis: a clinicopathologic study of 130 cases. Am J Surg Pathol. 2004;28(12):1545–52.CrossRef Olgac S, Mazumdar M, Dalbagni G. Urothelial carcinoma of the renal pelvis: a clinicopathologic study of 130 cases. Am J Surg Pathol. 2004;28(12):1545–52.CrossRef
5.
go back to reference Delahunt B, Nacey JN, Meffan PJ. Signet ring cell adenocarcinoma of the ureter [J]. Brit J Urol. 1991;68(5):555–6.CrossRef Delahunt B, Nacey JN, Meffan PJ. Signet ring cell adenocarcinoma of the ureter [J]. Brit J Urol. 1991;68(5):555–6.CrossRef
6.
go back to reference Roupret M, Babjuk M, Comperat E, et al. European association of urology guidelines on upper urinary tract urothelial carcinoma: 2017 update. Eur Urol. 2018;73(1):111–22.CrossRef Roupret M, Babjuk M, Comperat E, et al. European association of urology guidelines on upper urinary tract urothelial carcinoma: 2017 update. Eur Urol. 2018;73(1):111–22.CrossRef
7.
go back to reference Siggel RL, Miller KD. Cancer statitics, 2016. CA Cancer J Clin. 2016;66:7–30.CrossRef Siggel RL, Miller KD. Cancer statitics, 2016. CA Cancer J Clin. 2016;66:7–30.CrossRef
8.
go back to reference Siggel RL, Miller KD. Cancer statitics, 2015. CA Cancer J Clin. 2015;65:5–29.CrossRef Siggel RL, Miller KD. Cancer statitics, 2015. CA Cancer J Clin. 2015;65:5–29.CrossRef
9.
go back to reference Munoz JJ, et al. Upper tract urothelial neoplasms: incidence and survival during the last 2 decades. J Urol. 2000;164:1523.CrossRef Munoz JJ, et al. Upper tract urothelial neoplasms: incidence and survival during the last 2 decades. J Urol. 2000;164:1523.CrossRef
10.
go back to reference Shariat SF, et al. Gender differences in radical nephroureterectomy for upper tract urothelial carcinoma. World J Urol. 2011;29:481.CrossRef Shariat SF, et al. Gender differences in radical nephroureterectomy for upper tract urothelial carcinoma. World J Urol. 2011;29:481.CrossRef
12.
go back to reference Grignon DJ, Ro JY, Ayala AG, Johnson DE. Signet-ring cell carcinoma of the urinary bladder. Am J Pathol. 1955;31:223–31. Grignon DJ, Ro JY, Ayala AG, Johnson DE. Signet-ring cell carcinoma of the urinary bladder. Am J Pathol. 1955;31:223–31.
13.
go back to reference Ekfors TO. Primary signet-ring cell carcinoma of the ureter. A case report. APMIS. 1988;96:471–4.CrossRef Ekfors TO. Primary signet-ring cell carcinoma of the ureter. A case report. APMIS. 1988;96:471–4.CrossRef
14.
go back to reference Brawer MK, Waisman J. Papillary adenocarcinoma of ureter. Urology. 1982;19:205–9.CrossRef Brawer MK, Waisman J. Papillary adenocarcinoma of ureter. Urology. 1982;19:205–9.CrossRef
15.
go back to reference Nocks BN, Heney NM, Daly JJ. Primary adenocarcinoma of the urinary bladder. Urology. 1983;21:26–9.CrossRef Nocks BN, Heney NM, Daly JJ. Primary adenocarcinoma of the urinary bladder. Urology. 1983;21:26–9.CrossRef
16.
go back to reference Thomas DG, Ward AM, Williams JL. A study of 52 cases of adenocarcinoma of the bladder. Br J Urol. 1971;43:4–15.CrossRef Thomas DG, Ward AM, Williams JL. A study of 52 cases of adenocarcinoma of the bladder. Br J Urol. 1971;43:4–15.CrossRef
17.
go back to reference Ward AM. Glandular neoplasia within the urinary tract. The aetiology of adenocarcinoma of the urothelium with a review of the literature. I. Introduction: the origin of glandular epithelium in the renal pelvis, ureter and bladder. Virchows Arch A Pathol Pathol Anat. 1971;352:296–311.CrossRef Ward AM. Glandular neoplasia within the urinary tract. The aetiology of adenocarcinoma of the urothelium with a review of the literature. I. Introduction: the origin of glandular epithelium in the renal pelvis, ureter and bladder. Virchows Arch A Pathol Pathol Anat. 1971;352:296–311.CrossRef
18.
go back to reference Braun EV, Majid A, Fayemi A, Beaugard E. Primary signet-ring cell carcinoma of the urinary bladder: Review of the literature and report of a case. Cancer. 1981;47:1430–5.CrossRef Braun EV, Majid A, Fayemi A, Beaugard E. Primary signet-ring cell carcinoma of the urinary bladder: Review of the literature and report of a case. Cancer. 1981;47:1430–5.CrossRef
19.
go back to reference Choi H, Lamb S, Pintar K, Jacobs SC. Primary signet-ring cell carcinoma of the urinary bladder. Cancer. 1984;53:1985–90.CrossRef Choi H, Lamb S, Pintar K, Jacobs SC. Primary signet-ring cell carcinoma of the urinary bladder. Cancer. 1984;53:1985–90.CrossRef
20.
go back to reference DeTure FA, Dein R, Hackett RL, Drylie DM. Primary signet-ring cell carcinoma of bladder exemplifying vesical epithelial multipotentiality. Urology. 1975;6:240–4.CrossRef DeTure FA, Dein R, Hackett RL, Drylie DM. Primary signet-ring cell carcinoma of bladder exemplifying vesical epithelial multipotentiality. Urology. 1975;6:240–4.CrossRef
21.
go back to reference Abbas M, Kramer MW, Spieker T, Herrman TR, Merseburger AS, Müller KM, Kuczyk MA, Becker JU, Kreipe HH. Primary mucinous adenocarcinoma of the renal pelvis with carcinoma in situ in the ureter. J Egypt Natl Canc Inst. 2014;26:51–4.CrossRef Abbas M, Kramer MW, Spieker T, Herrman TR, Merseburger AS, Müller KM, Kuczyk MA, Becker JU, Kreipe HH. Primary mucinous adenocarcinoma of the renal pelvis with carcinoma in situ in the ureter. J Egypt Natl Canc Inst. 2014;26:51–4.CrossRef
23.
go back to reference Skolarikos A, et al. Cytologic analysis of ureteral washings is informative in patients with grade 2 upper tract TCC considering endoscopic treatment. Urology. 2003;61(6):1146–50.CrossRef Skolarikos A, et al. Cytologic analysis of ureteral washings is informative in patients with grade 2 upper tract TCC considering endoscopic treatment. Urology. 2003;61(6):1146–50.CrossRef
27.
go back to reference STEARNS DB, FARMER DA. Ureteral metastasis secondary to gastric carcinoma: case report. J Urol. 1958;80:214–7.CrossRef STEARNS DB, FARMER DA. Ureteral metastasis secondary to gastric carcinoma: case report. J Urol. 1958;80:214–7.CrossRef
28.
go back to reference Hes O, Curík R, Mainer K. Urothelial signet-ring cell carcinoma of the renal pelvis with collagenous spherulosis: a case report. Int J Surg Pathol. 2005;13:375–8.CrossRef Hes O, Curík R, Mainer K. Urothelial signet-ring cell carcinoma of the renal pelvis with collagenous spherulosis: a case report. Int J Surg Pathol. 2005;13:375–8.CrossRef
29.
go back to reference Singh J, Zherebitskiy V, Grynspan D, et al. Metastatic signet ring cell adenocarcinoma of the bladder. Can Urol Assoc J. 2013;6:E15–9.CrossRef Singh J, Zherebitskiy V, Grynspan D, et al. Metastatic signet ring cell adenocarcinoma of the bladder. Can Urol Assoc J. 2013;6:E15–9.CrossRef
31.
go back to reference Suh N, Yang XJ, Tretiakova MS, Humphrey PA, Wang HL. Value of CDX2, villin, and alpha-methylacyl coenzyme a racemase immunostains in the distinction between primary adenocarcinoma of the bladder and secondary colorectal adenocarcinoma. Mod Pathol. 2005;18:1217–22.CrossRef Suh N, Yang XJ, Tretiakova MS, Humphrey PA, Wang HL. Value of CDX2, villin, and alpha-methylacyl coenzyme a racemase immunostains in the distinction between primary adenocarcinoma of the bladder and secondary colorectal adenocarcinoma. Mod Pathol. 2005;18:1217–22.CrossRef
32.
go back to reference Dong MJ, Lin XT, Zhao J, et al. Malignant tumor with false negative 18F-FDG PET image. Zhonghua Zhong Liu Za Zhi. 2006;28:713–7.PubMed Dong MJ, Lin XT, Zhao J, et al. Malignant tumor with false negative 18F-FDG PET image. Zhonghua Zhong Liu Za Zhi. 2006;28:713–7.PubMed
33.
34.
go back to reference Birtle AJ, Chester JD, Jones RJ, et al. Results of POUT: A phase III randomised trial of perioperative chemotherapy versus surveillance in upper tract urothelial cancer (UTUC). J Clin Oncol. 2018;36(6_suppl):407.CrossRef Birtle AJ, Chester JD, Jones RJ, et al. Results of POUT: A phase III randomised trial of perioperative chemotherapy versus surveillance in upper tract urothelial cancer (UTUC). J Clin Oncol. 2018;36(6_suppl):407.CrossRef
35.
go back to reference Cobo-Dols M, Alcaide J, Gutiérrez V, et al. Primary signet-ring cell adenocarcinoma of the urinary bladder: a case report. Oncología (Barc). 2006;29:177–80. Cobo-Dols M, Alcaide J, Gutiérrez V, et al. Primary signet-ring cell adenocarcinoma of the urinary bladder: a case report. Oncología (Barc). 2006;29:177–80.
Metadata
Title
A case report of primary upper urinary tract signet-ring cell carcinoma and literature review
Authors
Zhaohua Ye
Qiwu Mi
Daosheng Luo
Zhixiong Li
Jiexin Luo
Publication date
01-12-2020
Publisher
BioMed Central
Published in
BMC Urology / Issue 1/2020
Electronic ISSN: 1471-2490
DOI
https://doi.org/10.1186/s12894-020-00645-y

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