Top

Published in:

01-02-2021 | Original Article

Nephroprotective role and antioxidant capacity of Atriplex halimus on carbon tetrachloride-induced kidney damage in rats

Authors: Kheira Slama, Meriem Rouag, Lazhari Tichati, Faiza Taibi, Mahieddine Boumendjel, Amel Boumendjel, Mahfoud Messarah

Published in: Comparative Clinical Pathology | Issue 1/2021

Abstract

The aim of this work was to study the nephroprotective role and antioxidant capacity of Atriplex halimus aqueous leaves extract (AHAE) against carbon tetrachloride-induced kidney injury in rats. The experimental rats were randomized into four experimental groups of eight each: Group (C) served as a control received a normal diet, Group (CCl₄) received a normal diet for 4 weeks and then was injected with one dose of 1.0 ml/kg body weight of carbon tetrachloride dissolved in olive oil (v/v) intraperitoneally, Group (AHAE + CCl4) received 200 mg/kg body weight of AHAE for 4 weeks and then was injected with one dose of 1.0 ml/kg body weight of carbon tetrachloride dissolved in olive oil (v/v) intraperitoneally, and Group (AHAE) received 200 mg/kg body weight of AHAE for 4 weeks. The AHAE nephroprotective effect was evaluated histopathologically and biochemically through measuring several indices in plasma, urine, and renal tissue homogenates. The results indicated that intraperitoneally injection of CCl4-induced severe kidney injury associated with oxidative stress by increased malondialdehyde (MDA), advanced oxidation protein product (AOPP), and hydrogen peroxide (H₂O₂) levels and reduced the antioxidant defense system such as reduced glutathione (GSH), vitamin C (Vit C), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione-S-transferase (GST) compared with control group. The pretreatment with AHAE significantly restored the majority of these biochemical parameters to normal levels, as well as improved the histopathological changes compared with CCl4-treated group. The obtained results highlighted the potential use of AHAE as a source of bioactive compounds with pharmacological advantages.

Abou-Hany HO, Atef H, Said E, Elkashef HA, Salem HA (2018) Crocin reverses unilateral renal ischemia reperfusion injury-induced augmentation of oxidative stress and toll like receptor-4 activity. Environmental toxicology and pharmacology, 1-31

Aebi H (1984) Catalase in vitro. Method Enzymol 105:121–126CrossRef

Akca G, Eren H, Tumkaya L, Mercantepe T, Horsanali MO, Deveci E, Dil E, Yilmaz A (2018) The protective effect of astaxanthin against cisplatin-induced nephrotoxicity in rats. Biomed Pharmacother 100:575–582PubMedCrossRef

Alibakhshi T, Khodayar MJ, Khorsandi L, Rashno M, Zeidooni L (2018) Protective effects of zingerone on oxidative stress and inflammation in cisplatin-induced rat nephrotoxicity. Biomed Pharmacother 105:225–232PubMedCrossRef

Altınkaynak Y, Kural B, Akcan BA, Bodur A, Özer S, Yuluğ E, Munğan S, Kaya C, Örem A (2018) Protective effects of L-theanine against doxorubicin-induced nephrotoxicity in rats. Biomed Pharmacother 108:1524–1534PubMedCrossRef

Anadozie SO, Akinyemi JA, Agunbiade S, Ajiboye BO, Adewale OB (2018) Bryophyllum pinnatum inhibits arginase II activity and prevents oxidative damage occasioned by carbon tetrachloride (CCl4) in rats. Biomed Pharmacother 101:8–13PubMedCrossRef

Asada K, Takahashi M, Nagat M (1974) Assay and inhibitors of spinach superoxide dismutase. AgricBiolChem 38:471–447

Badreldin Ali BH, Alza'abi M, Ramkumar A, Al-Lawati I, Waly MI, Beegam S, Nemmar A, Brand S, Schupp N (2014) The effect of activated charcoal on adenine-induced chronic renal failure in rats. Food ChemToxicol 65:321–328CrossRef

Bahashwan S, Memy HH, Hamdy A, Ghobara MM, El-Beshbishy HA, Busati IBS (2015) Crocin mitigates carbon tetrachloride-induced liver toxicityin rats. Journal of Taibah University Medical Sciences 10:140–149CrossRef

Blois MS (1958) Antioxidant determination by the use of stable free radical. Nature 26:199–200

Bourmita Y, Belboukhari N, Cheriti A, Ould El Hadj MD (2013) Recherche préliminaire des sources végétales sahariennes à alcaloïdes pour usage bio-insecticides. Algerian journal of arid environment 3:98–102CrossRef

Bradford M (1976) A rapid and sensitive method for the quantities of microgram quantities of protein utilizing the principal of protein binding. Anal Biochem 72:248–254PubMedCrossRef

Buege JA, Aust SD (1984) Microsomal lipid peroxidation. Method Enzymol 105:302–310

Bulle S, Reddy VD, Hebbani AV, Padmavathi P, Challa C, Puvvada PK, Repalle E, Nayakanti D, Aluganti Narasimhulu C, Nallanchakravarthula V (2016) Nephro-protective action of P. santalinus against alcohol-induced biochemical alterations and oxidative damage in rats. Biomed Pharmacother 84:740–746PubMedCrossRef

Chikhi I, Allali H, Dib MA, Medjdoub H, Tabti B (2014) Antidiabetic activity of aqueous leaf extract of Atriplex halimus L. (Chenopodiaceae) in streptozotocin-induced diabetic rats. Asian Pac J Trop Dis 4:181–184PubMedCentralCrossRef

De Almeida CLB, Cechinel-Filho V, Boeing T, Mariano LNB, Silva LMD, Andrade SF, de Souza P (2018) Prolonged diuretic and saluretic effect of nothofagin isolated from Leandra dasytricha (a. gray) Cogn. Leaves in normotensive and hypertensive rats: role of antioxidant system and renal protection. Chem Biol Interact 279:227–233PubMedCrossRef

De Menezes Peixoto CR, Fraga S, Justim JDR, Gomes MS, Carvalho DG, Jarenkow JA, de Moura NF (2017) Voltammetric determination of total antioxidant capacity of Bunchosia glandulifera tree extracts. J Electroanal Chem, 1–29

El-Ashmawy NE, Khedr NF, El-Bahrawy HA, Helal SA (2018) Upregulation of PPAR-γ mediates the renoprotective effect of omega-3 PUFA and ferulic acid in gentamicin-intoxicated rats. Biomed Pharmacother 99:504–510PubMedCrossRef

Ellman GL (1959) Tissue sulfhydryl groups. Arch BiochemiBiophys 82:70–77CrossRef

Farooqui Z, Ahmed F, Rizwan S, Shahid F, Khan AA, Khan F (2017) Protective effect of Nigella sativa oil on cisplatin induced nephrotoxicity and oxidative damage in rat kidney. Biomed Pharmacother 85:7–15PubMedCrossRef

Ferreira D, Pinto DCGA, Silva H, Girol AP, de Lourdes Pereira M (2018) Salicornia ramosissima J. woods seeds affected the normal regenerative function on carbon tetrachloride-induced liver and kidney injury. Biomed Pharmacother 107:283–291PubMedCrossRef

Flohe L, Gunzler WA (1984) Analysis of glutathione peroxidase. Method Enzymol 105:114–121CrossRef

Friday U, Chinedu I, Glory IN (2015) Effect of exposure of male albino rats to kerosene, diesel and petrol on kidney function. International Research Journal of Environment Sciences 4:12–18

Habig WJ, Pabst MJ, Jacoby WB (1974) Glutathione S-transferase, the first enzymatic step in mercapturic acid formation. J BiolChem 249:7130–7139

Hamed H, Gargouri M, Boulila S, Chaari F, Ghrab F, Kallel R, Ghannoudi Z, Boudawara T, Chaabouni S, Feki AE, Gargouri A (2018) Fermented camel milk prevents carbon tetrachloride induced acute injury in kidney of mice. J Dairy Res 85:251–256PubMedCrossRef

Jollow DJ, Mitchell JR, Zamppaglione Z et al (1974) Bromobenzene induced liver necrosis. Protective role of glutathione and evidence for 3, 4-bromobenzene oxide as the hepatotoxic metabolites. Pharmacology 11:51–157CrossRef

JulkunenTitto R (1985) Phenolics constituents in the leaves of northern willows: methods for the analysis of certain phenolics. J Agric Food Chem 33:213–217CrossRef

Kooti W, Hasanzadeh-Noohi Z, Sharafi-Ahvazi N, Asadi-Samani M, Ashtary-Larky D (2016) Phytochemistry, pharmacology, and therapeutic uses of black seed (Nigella sativa). Chin J Nat Med 14:0732–0745

Kuatsienu LE, Ansah C, Adinortey MB (2017) Toxicological evaluation and protective effect of ethanolic leaf extract of Launaea taraxacifolia on gentamicin induced rat kidney injury. Asian Pac J Trop Biomed 7:640–646CrossRef

Kumar M, Dahiya V, Kasala ER, Bodduluru LN, Lahkar M (2017) The renoprotective activity of hesperetin in cisplatin induced nephrotoxicity in rats: molecular and biochemical evidence. Biomed Pharmacother 89:1207–1215PubMedCrossRef

Makni M, Chtourou Y, Fetoui H, Garoui EM, Boudawara T, Zeghal N (2011) Evaluation of the antioxidant, anti-inflammatory and hepatoprotective properties of vanillin in carbon tetrachloride treated rats. Eur J Pharmacol 668:133–139PubMedCrossRef

Mbarki S, Alimi H, Bouzenna H, Elfeki A, Hfaiedh N (2017) Phytochemical study and protective effect of Trigonella foenumgraecum (fenugreek seeds) against carbon tetrachloride-induced toxicity in liver and kidney of male rat. Biomed Pharmacother 88:19–26PubMedCrossRef

Mejri H, Tir M, Feriani A, Ghazouani L, Allagui MS, Saidani-Tounsi M (2017) Does Eryngium maritimum seeds extract protect against CCl4 and cisplatin induced toxicity in rats: preliminary phytochemical screening and assessment of its in vitro and in vivo antioxidant activity and antifibrotic effect. J Funct Foods 37:363–372CrossRef

Mesnoua M, Mateos-Naranjo E, Barcia-Piedras JM, Pérez-Romero JA, Lotmani B, Redondo-Gómez S (2016) Physiological and biochemical mechanisms preventing cd-toxicity in the hyperaccumulator Atriplex halimus L. Plant Physiol Biochem 106:30–38PubMedCrossRef

Missoun F, Slimani M, Aoues A (2010) Toxic effect of lead on kidney function in rat Wistar. Afr J Biochem Res 4:21–27

Nader MA, Attia GM (2016) Beneficial effects of nilotinib, tyrosine kinase inhibitor on cyclosporine-a induced renal damage in rats. Int Immunopharmacol 33:1–7PubMedCrossRef

Oyaizu M (1986) Studies on product of browning reaction prepared from glucose amine. Jpn J Nutr 44:307–315CrossRef

Pourmorad F, Hosseinimehr SJ, Shahabimajd N (2006) Antioxidant activity, phenol and flavonoid contents of some selected Iranian medicinal plants. Afr J Biotechnol 5:1142–1145

Prieto P, Pineda M, Anguilar M (1999) Spectrophotometric quantitation of antioxidant capacity through the formation of a Phosphomolybdenum complex: specific application to the determination of vitamin E. Anal Biochem 269:337–341PubMedCrossRef

Rajamani K, Anantharaman P, Chidambaram N, Balasubramanian T, Somasundaram ST (2012) Padina boergessenii ameliorates carbon tetrachloride induced nephrotoxicity in Wistar rats. Journal of King Saud University – Science 24:227–232CrossRef

Rjeibia I, Feriani A, Ben Saad A, Ncib S, Sdayria J, Saidi I, Souid S, Hfaiedh N, Allagui MS (2017) Phytochemical characterization and bioactivity of Lyciumeuropaeum: a focus on antioxidant, antinociceptive, hepatoprotective and nephroprotective effects. Biomed Pharmacother 95:1441–1450CrossRef

Roe KM, Kuether CA (1943) Detection of ascorbic acid in whole blood and urine through 2, 4 DNPH derivative of dehydro ascorbic acid. J BiolChem 147:399–407

Safhi MM (2018) Nephroprotective effect of Zingerone against CCl4-induced renal toxicity in Swiss albino mice: molecular mechanism. Oxidative medicine and cellular longevity, 1-7

Sahar SDS, Azza AM, Nepveu F, Valentin A, Roques C (2015) Phenolic composition and prospective anti-infectious properties of Atriplex lindleyi. Asian Pac J Trop Dis 5(10):786–791CrossRef

Slama K, Boumendjel M, Taibi T, Boumendjel A, Messarah M (2019) Atriplex halimus aqueous extract abrogates carbon tetrachloride-induced hepatotoxicity by modulating biochemical and histological changes in rats. Arch Physiol Biochem 126:49–60. https://doi.org/10.1080/13813455.2018.1489852CrossRef

Venugopala RK, Arunachalam R, Eerike M, Rao KR, Radhakrishnan AK, Raghuraman LP, Meti V, Devi S (2016) Nephroprotective effect of ethanolic extract of Azimatetracantha root in glycerol induced acute renal failure in Wistar albino rats. J Tradit Complement Med 6:347–354CrossRef

Walker DJ, Lutts S, Sánchez-García M, Correal E (2014) Atriplex halimus L.: its biology and uses. J Arid Environ 100-101:111–121CrossRef

Witko-Sarsat V, Friedlander M, Capeillère-Blandin C, Nguyen-Khoa T, Nguyen AT, Zingraff J, Jungers P, Descamps-Latscha B (1996) Advanced oxidation protein products as a novel marker of oxidative stress in uremia. Kidney Int 49:1304–1313PubMedCrossRef

Wolfe K, Wu X, Liu RV (2003) Antioxidant activity of apple peals. J. Agric. Food Chem 51:609–614CrossRef

Wolff SP (1994) Ferrous ion oxidation in presence of ferric ion indicator xylenol orange for measurement of hydroperoxides. Methods Enzymol 233:182–189CrossRef

Yilmaz-Ozden T, Can A, Karatug A, Pala-Kara Z, Okyar A, Bolkent S (2014) Carbon tetrachloride-induced kidney damage and protective effect of Amaranthus lividus L. in rats. Toxicol Ind Health 1–11

Zariyantey A et al (2012) Nephroprotective effects of Zingiber zerumbet smith ethyl acetate extract against paracetamol-induced nephrotoxicity and oxidative stress in rats. Biomed & Biotechnol 13(3):176–185

Zhu X, Jiang X, Li A, Zhao Z, Li S (2017) S-Allylmercaptocysteine attenuates Cisplatin-induced nephrotoxicity through suppression of apoptosis, oxidative stress, and inflammation. Nutrients 9(166):1–16

Title: Nephroprotective role and antioxidant capacity of Atriplex halimus on carbon tetrachloride-induced kidney damage in rats
Authors: Kheira Slama
Meriem Rouag
Lazhari Tichati
Faiza Taibi
Mahieddine Boumendjel
Amel Boumendjel
Mahfoud Messarah
Publication date: 01-02-2021
Publisher: Springer London
Published in: Comparative Clinical Pathology / Issue 1/2021
Print ISSN: 1618-5641
Electronic ISSN: 1618-565X
DOI: https://doi.org/10.1007/s00580-021-03195-3

2024 ASCO Annual Meeting

Springer Medicine

Nephroprotective role and antioxidant capacity of Atriplex halimus on carbon tetrachloride-induced kidney damage in rats

Abstract

2024 ASCO Annual Meeting

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 1/2021

Serum calcium determination with atomic absorption spectrophotometry and colorimetric method: association and predictive equations between them in cattle and sheep samples

Serum protein capillary electrophoretic pattern during the neonatal period in dairy calves

Pathological changes in the mucous membrane of the small intestine due to prolonged consumption of palm oil

Clinical and laboratory findings in barren Arabian mares

Nutritional secondary hyperparathyroidism–induced facial osteodystrophy in a Labrador puppy

Modification of erythrogram, testosterone and prolactin profiles in jacks following experimental infection with Trypanosoma congolense