Skip to main content
Top
Published in: Indian Journal of Surgical Oncology 4/2022

02-05-2022 | Nephrectomy | Original Article

Comparative Analysis of Trifecta Outcomes in Robot-Assisted Partial Nephrectomy for cT1a Versus cT1b + Renal Tumours—a Single-Centre Study

Authors: Sunny Khanna Dilip, Danny Darlington Carbin, Surendra Singh, Saurabh Patil, Puneet Ahluwalia, Gagan Gautam

Published in: Indian Journal of Surgical Oncology | Issue 4/2022

Login to get access

Abstract

Robotic assistance is being increasingly utilised for nephron-sparing surgery for complex renal masses. We evaluated the outcomes of robot-assisted partial nephrectomy (RAPN) for cT1a versus cT1b + renal masses by a comparative analysis of trifecta outcomes between these two groups of patients. We utilised our prospectively maintained database to identify patients undergoing RAPN for cT1a (group 1, n = 41) and cT1b + (group 2, n = 37) renal masses from April 2016 to March 2020. The oncological and trifecta outcomes were analysed using appropriate statistical methods. Out of 78 patients, trifecta was achieved in 30 (38.4%) patients. There was no statistically significant difference in trifecta between cT1a and cT1b + tumours (p = 0.152). We found a statistically significant difference between the two groups in terms of RENAL scores (p = 0.0005), PADUA score (p = 0.0002), and robotic console time (133.8 ± 42.8 Vs 170 ± 54.8 min for cT1a versus cT1b + , respectively) (p = 0.002). On multivariate analysis, warm ischemia time (p = 0.069), blood loss (p = 0.345), UCS repair (p = 0.691) and GFR reduction (p = 0.152) were not statistically different. There was no statistically significant difference in intraoperative and post-operative complications (p = 0.9317) or length of hospital stay (p = 0.112). Although recurrences were observed in two patients (5.4%) of the cT1b group, there was no statistical difference in the recurrence-free survival at 12 and 24 months. Our study shows that RAPN can be safely done for cT1b + renal tumours. These findings reinforce the view that RAPN should be considered a viable option for cT1b + lesions whenever technically feasible.
Literature
1.
go back to reference Ljungberg B, Bensalah K, Canfield S, Dabestani S, Hofmann F, Hora M, Kuczyk MA, Lam T, Marconi L, Merseburger AS, Mulders P (2015) EAU guidelines on renal cell carcinoma: 2014 update. Eur Urol 67(5):913–924CrossRef Ljungberg B, Bensalah K, Canfield S, Dabestani S, Hofmann F, Hora M, Kuczyk MA, Lam T, Marconi L, Merseburger AS, Mulders P (2015) EAU guidelines on renal cell carcinoma: 2014 update. Eur Urol 67(5):913–924CrossRef
2.
go back to reference Borghesi M, Schiavina R, Gan M, Novara G, Mottrie A, Ficarra V (2013) Expanding utilisation of robotic partial nephrectomy for clinical T1b and complex T1a renal masses. World J Urol 31(3):499–504CrossRef Borghesi M, Schiavina R, Gan M, Novara G, Mottrie A, Ficarra V (2013) Expanding utilisation of robotic partial nephrectomy for clinical T1b and complex T1a renal masses. World J Urol 31(3):499–504CrossRef
3.
go back to reference Patel MN, Menon M, Rogers CG. Robotic partial nephrectomy: a comparison to current techniques. InUrologic Oncology: Seminars and Original Investigations 2010 (Vol. 28, No. 1, pp. 74–76). Elsevier. Patel MN, Menon M, Rogers CG. Robotic partial nephrectomy: a comparison to current techniques. InUrologic Oncology: Seminars and Original Investigations 2010 (Vol. 28, No. 1, pp. 74–76). Elsevier.
4.
go back to reference Patel HD, Mullins JK, Pierorazio PM, Jayram G, Cohen JE, Matlaga BR, Allaf ME (2013) Trends in renal surgery: robotic technology is associated with increased use of partial nephrectomy. J Urol 189(4):1229–1235CrossRef Patel HD, Mullins JK, Pierorazio PM, Jayram G, Cohen JE, Matlaga BR, Allaf ME (2013) Trends in renal surgery: robotic technology is associated with increased use of partial nephrectomy. J Urol 189(4):1229–1235CrossRef
5.
go back to reference Krane LS, Manny TB, Mufarrij PW, Hemal AK (2013) Does experience in creating a robot-assisted partial nephrectomy (RAPN) programme in an academic centre impact outcomes or complication rate? BJU Int 112(2):207–215CrossRef Krane LS, Manny TB, Mufarrij PW, Hemal AK (2013) Does experience in creating a robot-assisted partial nephrectomy (RAPN) programme in an academic centre impact outcomes or complication rate? BJU Int 112(2):207–215CrossRef
6.
go back to reference Mayer WA, Godoy G, Choi JM, Goh AC, Bian SX, Link RE (2012) Higher RENAL Nephrometry Score is predictive of longer warm ischemia time and collecting system entry during laparoscopic and robotic-assisted partial nephrectomy. Urology 79(5):1052–1056CrossRef Mayer WA, Godoy G, Choi JM, Goh AC, Bian SX, Link RE (2012) Higher RENAL Nephrometry Score is predictive of longer warm ischemia time and collecting system entry during laparoscopic and robotic-assisted partial nephrectomy. Urology 79(5):1052–1056CrossRef
7.
go back to reference Ray RP, Mahapatra RS, Khullar S, Pal DK, Kundu AK (2016) Clinical characteristics of renal cell carcinoma: Five years review from a tertiary hospital in Eastern India. Indian J Cancer 53(1):114CrossRef Ray RP, Mahapatra RS, Khullar S, Pal DK, Kundu AK (2016) Clinical characteristics of renal cell carcinoma: Five years review from a tertiary hospital in Eastern India. Indian J Cancer 53(1):114CrossRef
8.
go back to reference Agnihotri S, Kumar J, Jain M, Kapoor R, Mandhani A (2014) Renal cell carcinoma in India demonstrates early age of onset & a late stage of presentation. Indian J Med Res 140(5):624 Agnihotri S, Kumar J, Jain M, Kapoor R, Mandhani A (2014) Renal cell carcinoma in India demonstrates early age of onset & a late stage of presentation. Indian J Med Res 140(5):624
9.
go back to reference Joshi A, Anand A, Prabhash K, Noronha V, Shrirangwar S, Bakshi G, Pal M, Murthy V, Krishnatry R, Desai S, Menon S (2017) Kidney cancer demographics and outcome data from 2013 at a tertiary cancer hospital in India. Indian J Cancer 54(4):601CrossRef Joshi A, Anand A, Prabhash K, Noronha V, Shrirangwar S, Bakshi G, Pal M, Murthy V, Krishnatry R, Desai S, Menon S (2017) Kidney cancer demographics and outcome data from 2013 at a tertiary cancer hospital in India. Indian J Cancer 54(4):601CrossRef
10.
go back to reference Kim DK, Kim LH, Raheem AA, Shin TY, Alabdulaali I, Yoon YE, Han WK, Rha KH (2016) Comparison of trifecta and pentafecta outcomes between T1a and T1b renal masses following robot-assisted partial nephrectomy (RAPN) with minimum one year follow up: can RAPN for T1b renal masses be feasible? PLoS ONE 11(3):e0151738CrossRef Kim DK, Kim LH, Raheem AA, Shin TY, Alabdulaali I, Yoon YE, Han WK, Rha KH (2016) Comparison of trifecta and pentafecta outcomes between T1a and T1b renal masses following robot-assisted partial nephrectomy (RAPN) with minimum one year follow up: can RAPN for T1b renal masses be feasible? PLoS ONE 11(3):e0151738CrossRef
11.
go back to reference Rabadi MH, Aston CE (2016) Compare serum creatinine versus Renal 99mTc-DTPA scan determined glomerular filtration rates in veterans with traumatic spinal cord injury and meurogenic bladder. J Spinal Cord Med 39(6):638–644CrossRef Rabadi MH, Aston CE (2016) Compare serum creatinine versus Renal 99mTc-DTPA scan determined glomerular filtration rates in veterans with traumatic spinal cord injury and meurogenic bladder. J Spinal Cord Med 39(6):638–644CrossRef
12.
go back to reference Petros F, Sukumar S, Haber GP, Dulabon L, Bhayani S, Stifelman M, Kaouk J, Rogers C (2012) Multi-institutional analysis of robot-assisted partial nephrectomy for renal tumors> 4 cm versus≤ 4 cm in 445 consecutive patients. J Endourol 26(6):642–646CrossRef Petros F, Sukumar S, Haber GP, Dulabon L, Bhayani S, Stifelman M, Kaouk J, Rogers C (2012) Multi-institutional analysis of robot-assisted partial nephrectomy for renal tumors> 4 cm versus≤ 4 cm in 445 consecutive patients. J Endourol 26(6):642–646CrossRef
13.
go back to reference Patel MN, Krane LS, Bhandari A, Laungani RG, Shrivastava A, Siddiqui SA, Menon M, Rogers CG (2010) Robotic partial nephrectomy for renal tumors larger than 4 cm. Eur Urol 57(2):310–316CrossRef Patel MN, Krane LS, Bhandari A, Laungani RG, Shrivastava A, Siddiqui SA, Menon M, Rogers CG (2010) Robotic partial nephrectomy for renal tumors larger than 4 cm. Eur Urol 57(2):310–316CrossRef
14.
go back to reference Ficarra V, Bhayani S, Porter J, Buffi N, Lee R, Cestari A, Novara G, Mottrie A (2012) Robot-assisted partial nephrectomy for renal tumors larger than 4 cm: results of a multicenter, international series. World J Urol 30(5):665–670CrossRef Ficarra V, Bhayani S, Porter J, Buffi N, Lee R, Cestari A, Novara G, Mottrie A (2012) Robot-assisted partial nephrectomy for renal tumors larger than 4 cm: results of a multicenter, international series. World J Urol 30(5):665–670CrossRef
15.
go back to reference Gupta GN, Boris R, Chung P, Linehan WM, Pinto PA, Bratslavsky G. Robot-assisted laparoscopic partial nephrectomy for tumors greater than 4 cm and high nephrometry score: feasibility, renal functional, and oncological outcomes with minimum 1 year follow-up. InUrologic Oncology: Seminars and Original Investigations 2013 (Vol. 31, No. 1, pp. 51–56). Elsevier. Gupta GN, Boris R, Chung P, Linehan WM, Pinto PA, Bratslavsky G. Robot-assisted laparoscopic partial nephrectomy for tumors greater than 4 cm and high nephrometry score: feasibility, renal functional, and oncological outcomes with minimum 1 year follow-up. InUrologic Oncology: Seminars and Original Investigations 2013 (Vol. 31, No. 1, pp. 51–56). Elsevier.
16.
go back to reference Masson-Lecomte A, Yates DR, Bensalah K, Vaessen C, de la Taille A, Roumiguié M, Doumerc N, Bruyere F, Soustelle L, Droupy S, Roupret M (2013) Robot-assisted laparoscopic nephron sparing surgery for tumors over 4 cm: operative results and preliminary oncologic outcomes from a multicentre French study. European Journal of Surgical Oncology (EJSO) 39(7):799–803CrossRef Masson-Lecomte A, Yates DR, Bensalah K, Vaessen C, de la Taille A, Roumiguié M, Doumerc N, Bruyere F, Soustelle L, Droupy S, Roupret M (2013) Robot-assisted laparoscopic nephron sparing surgery for tumors over 4 cm: operative results and preliminary oncologic outcomes from a multicentre French study. European Journal of Surgical Oncology (EJSO) 39(7):799–803CrossRef
17.
go back to reference Maddox M, Mandava S, Liu J, Boonjindasup A, Lee BR (2015) Robotic partial nephrectomy for clinical stage T1b tumors: intermediate oncologic and functional outcomes. Clin Genitourin Cancer 13(1):94–99CrossRef Maddox M, Mandava S, Liu J, Boonjindasup A, Lee BR (2015) Robotic partial nephrectomy for clinical stage T1b tumors: intermediate oncologic and functional outcomes. Clin Genitourin Cancer 13(1):94–99CrossRef
18.
go back to reference Janda G, Deal A, Yang H, Nielsen M, Smith A, Pruthi RS, Wallen E, Woods M, Raynor M (2016) Single-institution experience with robotic partial nephrectomy for renal masses greater than 4 cm. J Endourol 30(4):384–389CrossRef Janda G, Deal A, Yang H, Nielsen M, Smith A, Pruthi RS, Wallen E, Woods M, Raynor M (2016) Single-institution experience with robotic partial nephrectomy for renal masses greater than 4 cm. J Endourol 30(4):384–389CrossRef
19.
go back to reference Reynolds CR, Delto JC, Paulucci DJ, Weinstein C, Badani K, Eun D, Abaza R, Porter J, Bhandari A, Hemal AK (2017) Comparison of perioperative and functional outcomes of robotic partial nephrectomy for cT 1a vs cT 1b renal masses. BJU Int 120(6):842–847CrossRef Reynolds CR, Delto JC, Paulucci DJ, Weinstein C, Badani K, Eun D, Abaza R, Porter J, Bhandari A, Hemal AK (2017) Comparison of perioperative and functional outcomes of robotic partial nephrectomy for cT 1a vs cT 1b renal masses. BJU Int 120(6):842–847CrossRef
20.
go back to reference Bernhard JC, Pantuck AJ, Wallerand H, Crepel M, Ferrière JM, Bellec L, Maurice-Tison S, Robert G, Albouy B, Pasticier G, Soulie M (2010) Predictive factors for ipsilateral recurrence after nephron-sparing surgery in renal cell carcinoma. Eur Urol 57(6):1080–1086CrossRef Bernhard JC, Pantuck AJ, Wallerand H, Crepel M, Ferrière JM, Bellec L, Maurice-Tison S, Robert G, Albouy B, Pasticier G, Soulie M (2010) Predictive factors for ipsilateral recurrence after nephron-sparing surgery in renal cell carcinoma. Eur Urol 57(6):1080–1086CrossRef
21.
go back to reference Shah PH, Moreira DM, Okhunov Z, Patel VR, Chopra S, Razmaria AA, Alom M, George AK, Yaskiv O, Schwartz MJ, Desai M (2016) Positive surgical margins increase risk of recurrence after partial nephrectomy for high risk renal tumors. J Urol 196(2):327–334CrossRef Shah PH, Moreira DM, Okhunov Z, Patel VR, Chopra S, Razmaria AA, Alom M, George AK, Yaskiv O, Schwartz MJ, Desai M (2016) Positive surgical margins increase risk of recurrence after partial nephrectomy for high risk renal tumors. J Urol 196(2):327–334CrossRef
22.
go back to reference Pavan N, Derweesh IH, Mir CM, Novara G, Hampton LJ, Ferro M, Perdonà S, Parekh DJ, Porpiglia F, Autorino R (2017) Outcomes of laparoscopic and robotic partial nephrectomy for large (> 4 cm) kidney tumors: systematic review and meta-analysis. Ann Surg Oncol 24(8):2420–2428CrossRef Pavan N, Derweesh IH, Mir CM, Novara G, Hampton LJ, Ferro M, Perdonà S, Parekh DJ, Porpiglia F, Autorino R (2017) Outcomes of laparoscopic and robotic partial nephrectomy for large (> 4 cm) kidney tumors: systematic review and meta-analysis. Ann Surg Oncol 24(8):2420–2428CrossRef
23.
go back to reference Hung AJ, Cai J, Simmons MN, Gill IS (2013) “Trifecta” in partial nephrectomy. J Urol 189(1):36–42CrossRef Hung AJ, Cai J, Simmons MN, Gill IS (2013) “Trifecta” in partial nephrectomy. J Urol 189(1):36–42CrossRef
24.
go back to reference Khalifeh A, Autorino R, Hillyer SP, Laydner H, Eyraud R, Panumatrassamee K, Long JA, Kaouk JH (2013) Comparative outcomes and assessment of trifecta in 500 robotic and laparoscopic partial nephrectomy cases: a single surgeon experience. J Urol 189(4):1236–1242CrossRef Khalifeh A, Autorino R, Hillyer SP, Laydner H, Eyraud R, Panumatrassamee K, Long JA, Kaouk JH (2013) Comparative outcomes and assessment of trifecta in 500 robotic and laparoscopic partial nephrectomy cases: a single surgeon experience. J Urol 189(4):1236–1242CrossRef
25.
go back to reference Porpiglia F, Bertolo R, Amparore D, Fiori C (2013) Margins, ischaemia and complications rate after laparoscopic partial nephrectomy: impact of learning curve and tumour anatomical characteristics. BJU Int 112(8):1125–1132CrossRef Porpiglia F, Bertolo R, Amparore D, Fiori C (2013) Margins, ischaemia and complications rate after laparoscopic partial nephrectomy: impact of learning curve and tumour anatomical characteristics. BJU Int 112(8):1125–1132CrossRef
26.
go back to reference Buffi N, Lista G, Larcher A, Lughezzani G, Ficarra V, Cestari A, Lazzeri M, Guazzoni G (2012) Margin, ischemia, and complications (MIC) score in partial nephrectomy: a new system for evaluating achievement of optimal outcomes in nephron-sparing surgery. Eur Urol 62(4):617–618CrossRef Buffi N, Lista G, Larcher A, Lughezzani G, Ficarra V, Cestari A, Lazzeri M, Guazzoni G (2012) Margin, ischemia, and complications (MIC) score in partial nephrectomy: a new system for evaluating achievement of optimal outcomes in nephron-sparing surgery. Eur Urol 62(4):617–618CrossRef
27.
go back to reference Carneiro A, Sivaraman A, Sanchez-Salas R, Di Trapani E, Barret E, Rozet F, Galiano M, Pizzaro FU, Doizi S, Cathala N, Mombet A (2015) Evolution from laparoscopic to robotic nephron sparing surgery: a high-volume laparoscopic center experience on achieving ‘trifecta’outcomes. World J Urol 33(12):2039–2044CrossRef Carneiro A, Sivaraman A, Sanchez-Salas R, Di Trapani E, Barret E, Rozet F, Galiano M, Pizzaro FU, Doizi S, Cathala N, Mombet A (2015) Evolution from laparoscopic to robotic nephron sparing surgery: a high-volume laparoscopic center experience on achieving ‘trifecta’outcomes. World J Urol 33(12):2039–2044CrossRef
28.
go back to reference Lista G, Buffi NM, Lughezzani G, Lazzeri M, Abrate A, Mistretta A, Larcher A, Dell’Oglio P, Fossati N, Porter J, Ficarra V (2015) Margin, ischemia, and complications system to report perioperative outcomes of robotic partial nephrectomy: a European Multicenter Observational Study (EMOS project). Urology 85(3):589–595CrossRef Lista G, Buffi NM, Lughezzani G, Lazzeri M, Abrate A, Mistretta A, Larcher A, Dell’Oglio P, Fossati N, Porter J, Ficarra V (2015) Margin, ischemia, and complications system to report perioperative outcomes of robotic partial nephrectomy: a European Multicenter Observational Study (EMOS project). Urology 85(3):589–595CrossRef
Metadata
Title
Comparative Analysis of Trifecta Outcomes in Robot-Assisted Partial Nephrectomy for cT1a Versus cT1b + Renal Tumours—a Single-Centre Study
Authors
Sunny Khanna Dilip
Danny Darlington Carbin
Surendra Singh
Saurabh Patil
Puneet Ahluwalia
Gagan Gautam
Publication date
02-05-2022
Publisher
Springer India
Published in
Indian Journal of Surgical Oncology / Issue 4/2022
Print ISSN: 0975-7651
Electronic ISSN: 0976-6952
DOI
https://doi.org/10.1007/s13193-022-01541-7

Other articles of this Issue 4/2022

Indian Journal of Surgical Oncology 4/2022 Go to the issue