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Published in: Journal of Medical Systems 7/2016

01-07-2016 | Transactional Processing Systems

Neonatal Jaundice Detection System

Authors: Mustafa Aydın, Fırat Hardalaç, Berkan Ural, Serhat Karap

Published in: Journal of Medical Systems | Issue 7/2016

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Abstract

Neonatal jaundice is a common condition that occurs in newborn infants in the first week of life. Today, techniques used for detection are required blood samples and other clinical testing with special equipment. The aim of this study is creating a non-invasive system to control and to detect the jaundice periodically and helping doctors for early diagnosis. In this work, first, a patient group which is consisted from jaundiced babies and a control group which is consisted from healthy babies are prepared, then between 24 and 48 h after birth, 40 jaundiced and 40 healthy newborns are chosen. Second, advanced image processing techniques are used on the images which are taken with a standard smartphone and the color calibration card. Segmentation, pixel similarity and white balancing methods are used as image processing techniques and RGB values and pixels’ important information are obtained exactly. Third, during feature extraction stage, with using colormap transformations and feature calculation, comparisons are done in RGB plane between color change values and the 8-color calibration card which is specially designed. Finally, in the bilirubin level estimation stage, kNN and SVR machine learning regressions are used on the dataset which are obtained from feature extraction. At the end of the process, when the control group is based on for comparisons, jaundice is succesfully detected for 40 jaundiced infants and the success rate is 85 %. Obtained bilirubin estimation results are consisted with bilirubin results which are obtained from the standard blood test and the compliance rate is 85 %.
Literature
1.
go back to reference Click, R., Dahl-Smith, J., Fowler, L., DuBose, J., Deneau-Saxton, M., and Herbert, J., An osteopathic approach to reduction of readmissions for neonatal jaundice. Osteopathic Family Physician. 5(1):17–23, 2013.CrossRef Click, R., Dahl-Smith, J., Fowler, L., DuBose, J., Deneau-Saxton, M., and Herbert, J., An osteopathic approach to reduction of readmissions for neonatal jaundice. Osteopathic Family Physician. 5(1):17–23, 2013.CrossRef
2.
go back to reference Brown A.K., Kernicterus: Past, Present, and Future. NeoReviews. Am. Acad. Pediatrics. 4 (2), 2003. Brown A.K., Kernicterus: Past, Present, and Future. NeoReviews. Am. Acad. Pediatrics. 4 (2), 2003.
3.
go back to reference Madlon-Kay, D. J., Recognition of the presence and severity of newborn jaundice by parents, nurses, physicians, and icterometer. Pediatrics. 100 (3), 1997. Madlon-Kay, D. J., Recognition of the presence and severity of newborn jaundice by parents, nurses, physicians, and icterometer. Pediatrics. 100 (3), 1997.
4.
go back to reference Garfunkel, L.C., Kaczorowski, J., Christy, C., Mosby's pediatric clinical advisor: instant diagnosis and treatment. Elsevier Health Sciences. 2002. Garfunkel, L.C., Kaczorowski, J., Christy, C., Mosby's pediatric clinical advisor: instant diagnosis and treatment. Elsevier Health Sciences. 2002.
5.
go back to reference Arias, I.M., Gartner, L.M., Seifter, S., and Furman, M., Prolonged neonatal unconjugated hyperbilirubinemia associated with breast feeding and a steroid, pregnane-3 (alpha), 20 (beta)-diol in maternal milk that inhibits glucuronide formation in vitro. J. Clin. Invest. 43(11):2037–2047, 1964.CrossRefPubMedPubMedCentral Arias, I.M., Gartner, L.M., Seifter, S., and Furman, M., Prolonged neonatal unconjugated hyperbilirubinemia associated with breast feeding and a steroid, pregnane-3 (alpha), 20 (beta)-diol in maternal milk that inhibits glucuronide formation in vitro. J. Clin. Invest. 43(11):2037–2047, 1964.CrossRefPubMedPubMedCentral
6.
go back to reference Murphy, J.F., Hughes, I., Verrier Jones, E.R., Gaskell, S., and Pike, A.W., Pregnanediols and breast-milk jaundice. Arch. Dis. Child. 56:474–476, 1981.CrossRefPubMedPubMedCentral Murphy, J.F., Hughes, I., Verrier Jones, E.R., Gaskell, S., and Pike, A.W., Pregnanediols and breast-milk jaundice. Arch. Dis. Child. 56:474–476, 1981.CrossRefPubMedPubMedCentral
7.
go back to reference Hafkamp, A.M., Oral treatment of unconjugated hyperbilirubinemia. Ponsen & Looijen B.V, Wageningen, The Netherlands, 2006. Hafkamp, A.M., Oral treatment of unconjugated hyperbilirubinemia. Ponsen & Looijen B.V, Wageningen, The Netherlands, 2006.
8.
go back to reference McDonagh, A.F., Movement of bilirubin and bilirubin conjugates across the placenta. Pediatrics. 119(5):1032–1033, 2007.CrossRefPubMed McDonagh, A.F., Movement of bilirubin and bilirubin conjugates across the placenta. Pediatrics. 119(5):1032–1033, 2007.CrossRefPubMed
9.
go back to reference Kramer, L.I., Advancement of dermal icterus in the jaundiced newborn. Amer. J. Dis. Child. 118:454–458, 1969.PubMed Kramer, L.I., Advancement of dermal icterus in the jaundiced newborn. Amer. J. Dis. Child. 118:454–458, 1969.PubMed
10.
go back to reference Burke, B., Robbins, J., and Hobbs, C., American Academy of Pediatrics Subcommittee on hyperbilirubinemia. Management of hyperbilirubinemia in the newborn infant 35 or more weeks of gestation. Pediatrics. 114(1):297–316, 2004.CrossRef Burke, B., Robbins, J., and Hobbs, C., American Academy of Pediatrics Subcommittee on hyperbilirubinemia. Management of hyperbilirubinemia in the newborn infant 35 or more weeks of gestation. Pediatrics. 114(1):297–316, 2004.CrossRef
11.
go back to reference Cremer, R.J., Perryman, P.W., and Richards, D.H., Influence of light on the hyperbilirubinaemia of infants. The Lancet, Elsevier. 271(7030):1094–1097, 1958.CrossRef Cremer, R.J., Perryman, P.W., and Richards, D.H., Influence of light on the hyperbilirubinaemia of infants. The Lancet, Elsevier. 271(7030):1094–1097, 1958.CrossRef
12.
go back to reference Cappellini, M.D., Di Montemuros, F.M., Sampietro, M., Tavazzi, D., and Fiorelli, G., The interaction between Gilbert's syndrome and G6PD deficiency influences bilirubin levels. Br. J. Haematol. 104(4):928–929, 1999.CrossRefPubMed Cappellini, M.D., Di Montemuros, F.M., Sampietro, M., Tavazzi, D., and Fiorelli, G., The interaction between Gilbert's syndrome and G6PD deficiency influences bilirubin levels. Br. J. Haematol. 104(4):928–929, 1999.CrossRefPubMed
13.
go back to reference Newman, T.B., Escobar, G.J., Gonzales, V.M., Armstrong, M.A., Gardner, M.N., Folck, B.F. Frequency of neonatal bilirubin testing and hyperbilirubinemia in a large health maintenance organization. Pediatrics. 104 (6), 1999. Newman, T.B., Escobar, G.J., Gonzales, V.M., Armstrong, M.A., Gardner, M.N., Folck, B.F. Frequency of neonatal bilirubin testing and hyperbilirubinemia in a large health maintenance organization. Pediatrics. 104 (6), 1999.
14.
go back to reference Stokowski, L.A., Fundamentals of phototherapy for neonatal jaundice. Adv. Neonatal. Care. 6(6):303–312, 2006.CrossRefPubMed Stokowski, L.A., Fundamentals of phototherapy for neonatal jaundice. Adv. Neonatal. Care. 6(6):303–312, 2006.CrossRefPubMed
15.
go back to reference Geifman-Holtzman, O., Wojtowycz, M., Kosmas, E., and Artal, R., Female Allo-immunization with antibodies known to cause hemolytic disease. Obstet. Gynecol. 89(2):272–275, 1997.CrossRefPubMed Geifman-Holtzman, O., Wojtowycz, M., Kosmas, E., and Artal, R., Female Allo-immunization with antibodies known to cause hemolytic disease. Obstet. Gynecol. 89(2):272–275, 1997.CrossRefPubMed
16.
go back to reference Mollison, P.L., Engelfriet, C.P., and Contreras, M., Blood transfusion in clinical medicine, 10th edn. Blackwell Science, Oxford, 1997. Mollison, P.L., Engelfriet, C.P., and Contreras, M., Blood transfusion in clinical medicine, 10th edn. Blackwell Science, Oxford, 1997.
17.
go back to reference Shapiro, L.G., and Stockman, G.C., Computer vision. Prentice-Hall, New Jersey, pp. 279–325, 2001. Shapiro, L.G., and Stockman, G.C., Computer vision. Prentice-Hall, New Jersey, pp. 279–325, 2001.
18.
go back to reference Rosenfeld, A., and Kak, A.C., Digital picture processing. Academic Press, San Diego, 1982. Rosenfeld, A., and Kak, A.C., Digital picture processing. Academic Press, San Diego, 1982.
19.
go back to reference Hsien-Che, L., Introduction to color imaging science. Cambridge University Press. pp 450, 2005. Hsien-Che, L., Introduction to color imaging science. Cambridge University Press. pp 450, 2005.
20.
go back to reference Sharma, G., and Bala, R., Digital color imaging handbook. CRC Press, Boca Raton, 2002.CrossRef Sharma, G., and Bala, R., Digital color imaging handbook. CRC Press, Boca Raton, 2002.CrossRef
21.
go back to reference De Greef, L., Goel, M., Seo, M.J., Larson, E.C., Stout, J.W., Taylor, J.A., Patel, S.N., Bilicam: using mobile phones to monitor newborn jaundice. UbiComp '14 Proceedings of the 2014 ACM International Joint Conference on Pervasive and Ubiquitous Computing. 331–342, 2014. De Greef, L., Goel, M., Seo, M.J., Larson, E.C., Stout, J.W., Taylor, J.A., Patel, S.N., Bilicam: using mobile phones to monitor newborn jaundice. UbiComp '14 Proceedings of the 2014 ACM International Joint Conference on Pervasive and Ubiquitous Computing. 331–342, 2014.
22.
go back to reference Forcade, N., Le Guyader, C., and Gout, C., Generalized fast marching method: applications to image segmentation. Numerical Algorithms. 48(1):189–211, 2008.CrossRef Forcade, N., Le Guyader, C., and Gout, C., Generalized fast marching method: applications to image segmentation. Numerical Algorithms. 48(1):189–211, 2008.CrossRef
23.
go back to reference Horowitz, S.L., Pavlidis, T., Picture segmentation by a directed split and merge procedure. Proc. ICPR. Denmark. 424–433, 1974. Horowitz, S.L., Pavlidis, T., Picture segmentation by a directed split and merge procedure. Proc. ICPR. Denmark. 424–433, 1974.
24.
go back to reference Haddad, R.A., and Akansu, A.N., A class of fast gaussian binomial filters for speech and image processing. IEEE Trans. Acoust. Speech Signal Process. 39(3):723–727, 1991.CrossRef Haddad, R.A., and Akansu, A.N., A class of fast gaussian binomial filters for speech and image processing. IEEE Trans. Acoust. Speech Signal Process. 39(3):723–727, 1991.CrossRef
25.
go back to reference Haindl, M., Mikes, S., Texture segmentation benchmark. Proc. of the 19th Int. conference on pattern recognition. IEEE Computer Society. 1–4, 2008. Haindl, M., Mikes, S., Texture segmentation benchmark. Proc. of the 19th Int. conference on pattern recognition. IEEE Computer Society. 1–4, 2008.
26.
go back to reference Chan, T.F., and Vese, L., Active contours without edges. IEEE Trans. Image Process. 10(2):266–277, 2001.CrossRefPubMed Chan, T.F., and Vese, L., Active contours without edges. IEEE Trans. Image Process. 10(2):266–277, 2001.CrossRefPubMed
27.
go back to reference Pratt, W.K., Digital image processing, 4th edn. Hoboken, John Willey & Sons, 2007.CrossRef Pratt, W.K., Digital image processing, 4th edn. Hoboken, John Willey & Sons, 2007.CrossRef
28.
go back to reference Demirci, R., Rule-based automatic segmentation of color images. AEU Int. J. Electron. Commun. 60(6):435–442, 2006.CrossRef Demirci, R., Rule-based automatic segmentation of color images. AEU Int. J. Electron. Commun. 60(6):435–442, 2006.CrossRef
29.
go back to reference Funt, B., Cardei, V., Barnard, K., Learning color constancy. Proceedings of the Fourth IS&T/SID Color Imaging Conference, 58–60, 1996. Funt, B., Cardei, V., Barnard, K., Learning color constancy. Proceedings of the Fourth IS&T/SID Color Imaging Conference, 58–60, 1996.
30.
go back to reference Yule, J.A.C., Principles of color reproduction. Wiley, New York, 1967. Yule, J.A.C., Principles of color reproduction. Wiley, New York, 1967.
31.
go back to reference Viggiano, J.A.S., Comparison of the accuracy of different white balancing options as quantified by their color constancy. Sensors and camera Systems for Scientific, industrial, and digital photography applications V: proceedings of the SPIE. Bellingham. WA: SPIE: the International Society for Optical Engineering. 5301:323–333, 2004. Viggiano, J.A.S., Comparison of the accuracy of different white balancing options as quantified by their color constancy. Sensors and camera Systems for Scientific, industrial, and digital photography applications V: proceedings of the SPIE. Bellingham. WA: SPIE: the International Society for Optical Engineering. 5301:323–333, 2004.
32.
go back to reference Petschnigg, G., Szeliski, R., Agrawala, M., Cohen, M., Hoppe, H., and Toyama, K., Digital photography with flash and no-flash image pairs. ACM Trans. Graph. 23(3):664–672, 2004.CrossRef Petschnigg, G., Szeliski, R., Agrawala, M., Cohen, M., Hoppe, H., and Toyama, K., Digital photography with flash and no-flash image pairs. ACM Trans. Graph. 23(3):664–672, 2004.CrossRef
33.
go back to reference Schwarz, M.W., Cowan, W.B., and Beatty, J.C., An experimental comparison of RGB, YIQ, LAB, HSV, and opponent color models. ACM Trans. Graph. 6(2):123–158, 1987.CrossRef Schwarz, M.W., Cowan, W.B., and Beatty, J.C., An experimental comparison of RGB, YIQ, LAB, HSV, and opponent color models. ACM Trans. Graph. 6(2):123–158, 1987.CrossRef
34.
go back to reference Florack, L., and Kuijper, A., The topological structure of scale-space images. J. Math. Imaging Vision. 12(1):65–79, 2000.CrossRef Florack, L., and Kuijper, A., The topological structure of scale-space images. J. Math. Imaging Vision. 12(1):65–79, 2000.CrossRef
35.
go back to reference Liu, D.Y., Chen, H.L., Yang, B., Lv, X.E., Li, L.N., and Liu, J., Design of an Enhanced Fuzzy k-nearest neighbor classifier based computer aided diagnostic system for thyroid disease. J. Med. Syst. 36(5):3243–3254, 2012.CrossRefPubMed Liu, D.Y., Chen, H.L., Yang, B., Lv, X.E., Li, L.N., and Liu, J., Design of an Enhanced Fuzzy k-nearest neighbor classifier based computer aided diagnostic system for thyroid disease. J. Med. Syst. 36(5):3243–3254, 2012.CrossRefPubMed
36.
go back to reference Coomans, D., and Massart, D.L., Alternative k-nearest neighbour rules in supervised pattern recognition: Part 1. k-Nearest neighbour classification by using alternative voting rules. Anal. Chim. Acta. 136:15–27, 1982.CrossRef Coomans, D., and Massart, D.L., Alternative k-nearest neighbour rules in supervised pattern recognition: Part 1. k-Nearest neighbour classification by using alternative voting rules. Anal. Chim. Acta. 136:15–27, 1982.CrossRef
37.
go back to reference Nouira, K., and Trabelsi, A., Intelligent monitoring system for intensive care units. J. Med. Syst. 36(4):2309–2318, 2012.CrossRefPubMed Nouira, K., and Trabelsi, A., Intelligent monitoring system for intensive care units. J. Med. Syst. 36(4):2309–2318, 2012.CrossRefPubMed
38.
go back to reference Berikol, G.B., Yildiz, O., and Özcan, İ.T., Diagnosis of acute coronary syndrome with a support vector machine. J. Med. Syst. 40:84, 2016.CrossRefPubMed Berikol, G.B., Yildiz, O., and Özcan, İ.T., Diagnosis of acute coronary syndrome with a support vector machine. J. Med. Syst. 40:84, 2016.CrossRefPubMed
39.
go back to reference Cortes, C., and Vapnik, V., Support-vector networks. Mach. Learn. 20(3):273, 1995. Cortes, C., and Vapnik, V., Support-vector networks. Mach. Learn. 20(3):273, 1995.
40.
go back to reference Leartveravat, S., Transcutaneous bilirubin measurement in full term neonate by digital camera. Medical Journal of Srisaket Surin Buriram Hospitals. 24(1):105–118, 2009. Leartveravat, S., Transcutaneous bilirubin measurement in full term neonate by digital camera. Medical Journal of Srisaket Surin Buriram Hospitals. 24(1):105–118, 2009.
41.
go back to reference Nagar, G., Vandermeer, B., Campbell, S., and Kumar, M., Reliability of transcutaneous bilirubin devices in preterm infants: a systematic review. Pediatrics. 132(5):871–881, 2013.CrossRefPubMed Nagar, G., Vandermeer, B., Campbell, S., and Kumar, M., Reliability of transcutaneous bilirubin devices in preterm infants: a systematic review. Pediatrics. 132(5):871–881, 2013.CrossRefPubMed
Metadata
Title
Neonatal Jaundice Detection System
Authors
Mustafa Aydın
Fırat Hardalaç
Berkan Ural
Serhat Karap
Publication date
01-07-2016
Publisher
Springer US
Published in
Journal of Medical Systems / Issue 7/2016
Print ISSN: 0148-5598
Electronic ISSN: 1573-689X
DOI
https://doi.org/10.1007/s10916-016-0523-4

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