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Annals of Surgical Oncology
Published in: Annals of Surgical Oncology 4/2018

01-04-2018 | Head and Neck Oncology

Neoadjuvant Chemotherapy for Hypopharyngeal Squamous Cell Carcinoma and Personalized Medicine in Head and Neck Cancer

Author: Eli Gordin, MD, FACS

Published in: Annals of Surgical Oncology | Issue 4/2018

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Excerpt

The treatment of head and neck cancer has long stood on the three pillars of surgery, chemotherapy and radiation. While the indications for and timing of administration of these modalities fluctuates, the fundamental principles of treatment have remained essentially unchanged. Therapeutic shifts have been limited to refinements in these techniques, such as minimally invasive surgery, modifications in radiation delivery, and the timing of chemotherapy administration; however, minimal improvement in survival for advanced cancers has been attained. Meanwhile, targeted therapies have shown promising results for treating cancer of the breast, colon, and lung, although head and neck cancer has enjoyed less robust success. …
Literature
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Joshi P, Joshi A, Norohna V, et al. Role of neoadjuvant chemotherapy in advanced carcinoma of the hypopharynx and larynx. South Asian J Cancer. 2017;6(1):15–19.CrossRefPubMedPubMedCentral
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Prades JM, Lallemant B, Garrel R, et al. Randomized phase III trial comparing induction chemotherapy followed by radiotherapy to concomitant chemoradiotherapy for laryngeal preservation in T3M0 pyriform sinus carcinoma. Acta Oto-Laryngol. 2010;130:150–55.CrossRefPubMed
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Patil VM, Prabhash K, Noronha V. Neoadjuvant chemotherapy followed by surgery in very locally advanced technically unresectable oral cavity cancers. Oral Oncol. 2014;50(10):1000–4.CrossRefPubMed
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Sahu P, Patil VM, Joshi A, et al. Neoadjuvant chemotherapy and surgical margin in technically unresectable buccal mucosa cancers. Oral Oncol. 2015;51(12):e91–e92.CrossRefPubMed
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Metadata
Title
Neoadjuvant Chemotherapy for Hypopharyngeal Squamous Cell Carcinoma and Personalized Medicine in Head and Neck Cancer
Author
Eli Gordin, MD, FACS
Publication date
01-04-2018
Publisher
Springer International Publishing
Published in
Annals of Surgical Oncology / Issue 4/2018
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-017-6258-8

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