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BMC Complementary Medicine and Therapies

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Open Access 01-12-2017 | Research article

Nelumbo nucifera leaves extracts inhibit mouse airway smooth muscle contraction

Authors: Xiao Yang, Lu Xue, Qingyang Zhao, Congli Cai, Qing-Hua Liu, Jinhua Shen

Published in: BMC Complementary Medicine and Therapies | Issue 1/2017

Abstract

Background

Alkaloids extracted from lotus leaves (AELL) can relax vascular smooth muscle. However, whether AELL has a similar relaxant role on airway smooth muscle (ASM) remains unknown. This study aimed to explore the relaxant property of AELL on ASM and the underlying mechanism.

Methods

Alkaloids were extracted from dried lotus leaves using the high temperature rotary evaporation extraction method. The effects of AELL on mouse ASM tension were studied using force measuring and patch-clamp techniques.

Results

It was found that AELL inhibited the high K⁺ or acetylcholine chloride (ACh)-induced precontraction of mouse tracheal rings by 64.8 ± 2.9%, or 48.8 ± 4.7%, respectively. The inhibition was statistically significant and performed in a dose-dependent manner. Furthermore, AELL-induced smooth muscle relaxation was partially mediated by blocking voltage-dependent Ca²⁺ channels (VDCC) and non-selective cation channels (NSCC).

Conclusion

AELL, which plays a relaxant role in ASM, might be a new complementary treatment to treat abnormal contractions of the trachea and asthma.

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Title: Nelumbo nucifera leaves extracts inhibit mouse airway smooth muscle contraction
Authors: Xiao Yang
Lu Xue
Qingyang Zhao
Congli Cai
Qing-Hua Liu
Jinhua Shen
Publication date: 01-12-2017
Publisher: BioMed Central
Published in: BMC Complementary Medicine and Therapies / Issue 1/2017
Electronic ISSN: 2662-7671
DOI: https://doi.org/10.1186/s12906-017-1674-7

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Nelumbo nucifera leaves extracts inhibit mouse airway smooth muscle contraction

Abstract

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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