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BMC Public Health
Published in: BMC Public Health 1/2014

Open Access 01-12-2014 | Research article

Negative life events and migraine: a cross-sectional analysis of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) baseline data

Authors: Itamar S Santos, André R Brunoni, Alessandra C Goulart, Rosane H Griep, Paulo A Lotufo, Isabela M Benseñor

Published in: BMC Public Health | Issue 1/2014

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Abstract

Background

Stress is a typical migraine trigger. However, the impact of negative life events on migraine activity is poorly studied. The aim of this study is to investigate the association between negative life events and migraine using data from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) baseline assessment.

Methods

ELSA-Brasil is a multicenter cohort study conducted in six Brazilian cities. Baseline assessment included validated questionnaires for headache classification and the occurrence of five pre-specified negative life events (financial hardship, hospitalization other than for childbirth, death of a close relative, robbery and end of a love relationship), focusing on a 12-month period before evaluation. We built crude and adjusted logistic regression models to study the association between the occurrences of negative life events and migraine diagnosis and activity.

Results

We included 4,409 individuals with migraine and 4,457 participants without headache (reference). After adjustment for age, sex, race, income and educational level, we found that the occurrence of a negative life event (Odds ratio = 1.31; 95% confidence interval = 1.19 – 1.45) was associated with migraine. However, after stratifying with subgroup analyses, only financial hardship (Odds ratio = 1.65; 95% confidence interval = 1.47 – 1.87) and hospitalization (Odds ratio = 1.47; 95% confidence interval = 1.25 – 1.72) were independently associated with migraine. Further adjustment for a current major depression episode and report of religious activity did not significantly change the results. Considering migraine frequency as (a) less than once per month, (b) once per month to once per week, or (c) more than once per week, financial hardship and hospitalization remained significantly associated with migraine in all episode frequency strata, with higher odds ratios for higher frequencies in adjusted models. We also observed a significant association between the death of a close relative and the highest migraine frequency stratum (Odds ratio = 1.38; 95% confidence interval = 1.09 – 1.75) in full-adjusted model.

Conclusions

The occurrence of financial hardship and hospitalization had a direct and independent association with migraine diagnosis and frequency. The death of a close relative was also independently associated with the highest migraine frequency stratum.
Appendix
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Literature
1.
Brugha T, Bebbington P, Tennant C, Hurry J: The list of threatening experiences: a subset of 12 life event categories with considerable long–term contextual threat. Psychol Med. 1985, 15: 189-194.CrossRefPubMed
2.
Slopen N, Williams DR, Fitzmaurice GM, Gilman SE: Sex, stressful life events, and adult onset depression and alcohol dependence: are men and women equally vulnerable?. Soc Sci Med. 2011, 73: 615-622.CrossRefPubMed
3.
Wichers M, Maes HH, Jacobs N, Derom C, Thiery E, Kendler KS: Disentangling the causal inter–relationship between negative life events and depressive symptoms in women: a longitudinal twin study. Psychol Med. 2012, 42: 1801-1814.CrossRefPubMed
4.
Bodell LP, Smith AR, Holm–Denoma JM, Gordon KH, Joiner TE: The impact of perceived social support and negative life events on bulimic symptoms. Eat Behav. 2011, 12: 44-48.CrossRefPubMed
5.
Lewis KM, Byrd DA, Ollendick TH: Anxiety symptoms in African–American and Caucasian youth: relations to negative life events, social support, and coping. J Anxiety Disord. 2012, 26: 32-39.CrossRefPubMed
6.
Rowe CA, Walker KL, Britton PC, Hirsch JK: The relationship between negative life events and suicidal behavior. Moderating role of basic psychological needs. Crisis. 2013, 34: 233-241.CrossRefPubMed
7.
Rosnick CB, Small BJ, McEvoy CL, Borenstein AR, Mortimer JA: Negative life events and cognitive performance in a population of older adults. J Aging Health. 2007, 19: 612-629.CrossRefPubMed
8.
Henry P, Auray JP, Gaudin AF, Dartigues JF, Duru G, Lantéri–Minet M, Lucas C, Pradalier A, Chazot G, El Hasnaoui A: Prevalence and clinical characteristics of migraine in France. Neurology. 2002, 59: 232-237.CrossRefPubMed
9.
Kelman L: The triggers or precipitants of the acute migraine attack. Cephalalgia. 2007, 27: 394-402.CrossRefPubMed
10.
Holm JE, Lokken C, Myers TC: Migraine and stress: a daily examination of temporal relationships in women migraineurs. Headache. 1997, 37: 553-558.CrossRefPubMed
11.
Spierings EL, Sorbi M, Haimowitz BR, Tellegen B: Changes in daily hassles, mood, and sleep in the 2 days before a migraine headache. Clin J Pain. 1996, 12: 38-42.CrossRefPubMed
12.
Hashizume M, Yamada U, Sato A, Hayashi K, Amano Y, Makino M, Yoshiuchi K, Tsuboi K: Stress and psychological factors before a migraine attack: a time-based analysis. Biopsychosoc Med. 2008, 2: 14-CrossRefPubMedPubMedCentral
13.
Wöber C, Brannath W, Schmidt K, Kapitan M, Rudel E, Wessely P, Wöber-Bingöl C, PAMINA Study Group: Prospective analysis of factors related to migraine attacks: the PAMINA Study. Cephalalgia. 2007, 27: 304-314.CrossRefPubMed
14.
Lipton RB, Buse DC, Hall CB, Tennen H, Defreitas TA, Borkowski TM, Grosberg BM, Haut SR: Reduction in perceived stress as a migraine trigger: testing the “let-down headache” hypothesis. Neurology. 2014, 82: 1395-1401.CrossRefPubMedPubMedCentral
15.
Reynolds DJ, Hovanitz CA: Life event stress and headache frequency revisited. Headache. 2000, 40: 111-118.CrossRefPubMed
16.
Hedborg K, Anderberg UM, Muhr C: Stress in migraine: personality–dependent vulnerability, life events, and gender are of significance. Ups J Med Sci. 2011, 116: 187-199.CrossRefPubMedPubMedCentral
17.
Scher AI, Stewart WF, Buse D, Krantz DS, Lipton RB: Major life changes before and after the onset of chronic daily headache: a population-based study. Cephalalgia. 2008, 28: 868-876.CrossRefPubMed
18.
Larsson B, Sund AM: One-year incidence, course, and outcome predictors of frequent headaches among early adolescents. Headache. 2005, 45: 684-691.CrossRefPubMed
19.
Morillo LE, Alarcon F, Aranaga N, Aulet S, Chapman E, Conterno L, Estevez E, Garcia–Pedroza F, Garrido J, Macias–Islas M, Monzillo P, Nunez L, Plascencia N, Rodriguez C, Takeuchi Y, for the Latin American Migraine Study Group: Prevalence of Migraine in Latin America. Headache. 2005, 45: 106-117.CrossRefPubMed
20.
Queiroz LP, Peres MF, Piovesan EJ, Kowacs F, Ciciarelli MC, Souza JA, Zukerman E: A nationwide population–based study of migraine in Brazil. Cephalalgia. 2009, 29: 642-649.CrossRefPubMed
21.
Lipton RB, Stewart WF, Celentano DD, Reed ML: Undiagnosed migraine headaches: a comparison of symptom-based and reported physician diagnosis. Arch Intern Med. 1992, 152: 1273-1278.CrossRefPubMed
22.
Aquino EML, Barreto SM, Bensenor IM, Carvalho MS, Chor D, Duncan BB, Lotufo PA, Mill JG, Molina Mdel C, Mota EL, Passos VM, Schmidt MI, Szklo M: Brazilian Longitudinal Study of Adult Health (ELSA–Brasil): objectives and design. Am J Epidemiol. 2012, 175: 315-324.CrossRefPubMed
23.
Bensenor IM, Griep RH, Pinto KA, Faria CP, Felisbino-Mendes M, Caetano EI, Albuquerque LS, Schmidt MI: Routines of organization of clinical tests and interviews in the ELSA-Brasil investigation center. Rev Saude Publica. 2013, 47 (Suppl 2): 37-47.CrossRefPubMed
24.
The Headache Classification Committee of the International Headache Society: The international classification of headache disorders. Cephalalgia. 2004, 24 (Suppl 1): 9-160.
25.
Benseñor IJ, Lotufo PA, Pereira AC, Tannuri AC, Issa FK, Akashi D, Fucciolo DQ, Kakuda ES, Kanashiro H, Lobato ML, Titan SO, Galvão TF, Martins MA: Validation of a questionnaire for the diagnosis of headache in an outpatient clinic at a university hospital. Arq Neuropsiquiatr. 1997, 55: 364-369.CrossRefPubMed
26.
Benseñor IM, Lotufo PA, Goulart AC, Menezes PR, Scazufca M: The prevalence of headache among elderly in a low–income area of São Paulo, Brazil. Cephalalgia. 2008, 28: 329-333.CrossRefPubMed
27.
Benseñor IM, Goulart AC, Lotufo PA, Menezes PR, Scazufca M: Cardiovascular risk factors associated with migraine among the elderly with a low income: the Sao Paulo Ageing & Health Study (SPAH). Cephalalgia. 2011, 31: 331-337.CrossRefPubMed
28.
Lopes CS, Faerstein E: Reliability of reported stressful life events reported in a self–administered questionnaire: Pró–Saúde Study. Rev Bras Psiquiatr. 2001, 23: 126-133.
29.
Lewis G, Pelosi AJ, Araya R, Dunn G: Measuring psychiatric disorder in the community: a standardized assessment for use by lay interviewers. Psychol Med. 1992, 22: 465-486.CrossRefPubMed
30.
Steiner TJ, Scher AI, Stewart WF, Kolodner K, Liberman J, Lipton RB: The prevalence and disability burden of adult migraine in England and their relationships to age, gender and ethnicity. Cephalalgia. 2003, 23: 519-527.CrossRefPubMed
31.
Lipton RB, Stewart WF, Diamond S, Diamond ML, Reed M: Prevalence and burden of migraine in the United States: data from the American Migraine Study II. Headache. 2001, 41: 646-657.CrossRefPubMed
32.
Winter AC, Berger K, Buring JE, Kurth T: Associations of socioeconomic status with migraine and non–migraine headache. Cephalalgia. 2012, 32: 159-170.CrossRefPubMed
33.
R Core Team: R: A Language and Environment for Statistical Computing. 2012, Vienna: R Foundation for Statistical Computing
34.
35.
Francis JL, Moitra E, Dyck I, Keller MB: The impact of stressful life events on relapse of generalized anxiety disorder. Depress Anxiety. 2012, 29: 386-391.CrossRefPubMedPubMedCentral
36.
Wittstein IS, Thiemann DR, Lima JA, Baughman KL, Schulman SP, Gerstenblith G, Wu KC, Rade JJ, Bivalacqua TJ, Champion HC: Neurohumoral features of myocardial stunning due to sudden emotional stress. N Engl J Med. 2005, 352: 539-548.CrossRefPubMed
37.
D'Andrea G, D'Arrigo A, Dalle Carbonare M, Leon A: Pathogenesis of migraine: role of neuromodulators. Headache. 2012, 52: 1155-1163.CrossRefPubMed
38.
Heim C, Owens MJ, Plotsky PM, Nemeroff CB: The role of early adverse life events in the etiology of depression and posttraumatic stress disorder. Focus on corticotropin–releasing factor. Ann N Y Acad Sci. 1997, 821: 194-207.CrossRefPubMed
39.
Faravelli C, Lo Sauro C, Lelli L, Pietrini F, Lazzeretti L, Godini L, Benni L, Fioravanti G, Talamba GA, Castellini G, Ricca V: The role of life events and HPA axis in anxiety disorders: a review. Curr Pharm Des. 2012, 18: 5663-5674.CrossRefPubMed
40.
Patacchioli FR, Monnazzi P, Simeoni S, De Filippis S, Salvatori E, Coloprisco G, Martelletti P: Salivary cortisol, dehydroepiandrosterone–sulphate (DHEA–S) and testosterone in women with chronic migraine. J Headache Pain. 2006, 7: 90-94.CrossRefPubMedPubMedCentral
41.
Holm JE, Lamberty K, McSherry WC, Davis PA: The stress response in headache sufferers: physiological and psychological reactivity. Headache. 1997, 37: 221-227.CrossRefPubMed
42.
Andreatta M, Puschmann AK, Sommer C, Weyers P, Pauli P, Mühlberger A: Altered processing of emotional stimuli in migraine: an event–related potential study. Cephalalgia. 2012, 32: 1101-1108.CrossRefPubMed
43.
Borsook D, Maleki N, Becerra L, McEwen B: Understanding migraine through the lens of maladaptive stress responses: a model disease of allostatic load. Neuron. 2012, 73: 219-234.CrossRefPubMed
44.
Lynch JW, Kaplan GA, Shema SJ: Cumulative impact of sustained economic hardship on physical, cognitive, psychological, and social functioning. N Engl J Med. 1997, 337: 1889-1895.CrossRefPubMed
45.
Hawkins K, Wang S, Rupnow M: Direct cost burden among insured US employees with migraine. Headache. 2008, 48: 553-563.CrossRefPubMed
46.
Stack JM: Grief reactions and depression in family practice: differential diagnosis and treatment. J Fam Pract. 1982, 14: 271-275.PubMed
47.
48.
Kaiser RS, Primavera JP: Failure to mourn as a possible contributory factor to headache onset in adolescence. Headache. 1993, 33: 69-72.CrossRefPubMed
49.
50.
Karademas EC, Tsagaraki A, Lambrou N: Illness acceptance, hospitalization stress and subjective health in a sample of chronic patients admitted to hospital. J Health Psychol. 2009, 14: 1243-1250.CrossRefPubMed
51.
Sveen J, Eilegård A, Steineck G, Kreicbergs U: They still grieve-a nationwide follow-up of young adults 2-9 years after losing a sibling to cancer. Psychooncology. 2014, 23: 658-664.CrossRefPubMed
52.
Wardenaar KJ, van Veen T, Giltay EJ, Zitman FG, Penninx BW: The use of symptom dimensions to investigate the longitudinal effects of life events on depressive and anxiety symptomatology. J Affect Disord. 2014, 156: 126-133.CrossRefPubMed
53.
Bradshaw M, Ellison CG: Financial hardship and psychological distress: exploring the buffering effects of religion. Social Sci Med. 2010, 71: 196-204.CrossRef
54.
Kidwai R, Mancha BE, Brown QL, Eaton VW: The effect of spirituality and religious attendance on the relationship between psychological distress and negative life events. Soc Psychiatry Psychiatr Epidemiol. 2014, 49: 487-497.CrossRefPubMed
55.
Assari S: Race and ethnicity, religion involvement, church–based social support and subjective health in United States: a case of moderated mediation. Int J Prev Med. 2013, 4: 208-217.PubMedPubMedCentral
Metadata
Title
Negative life events and migraine: a cross-sectional analysis of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) baseline data
Authors
Itamar S Santos
André R Brunoni
Alessandra C Goulart
Rosane H Griep
Paulo A Lotufo
Isabela M Benseñor
Publication date
01-12-2014
Publisher
BioMed Central
Published in
BMC Public Health / Issue 1/2014
Electronic ISSN: 1471-2458
DOI
https://doi.org/10.1186/1471-2458-14-678

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