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01-09-2009 | Original Article

Negative Impact of Blood Transfusion on Recurrence and Prognosis of Hepatocellular Carcinoma After Hepatic Resection

Authors: Hiroaki Shiba, Yuichi Ishida, Shigeki Wakiyama, Tomonori Iida, Michinori Matsumoto, Taro Sakamoto, Ryusuke Ito, Takeshi Gocho, Kenei Furukawa, Yuki Fujiwara, Shoichi Hirohara, Takeyuki Misawa, Katsuhiko Yanaga

Published in: Journal of Gastrointestinal Surgery | Issue 9/2009

Abstract

Background

In perioperative management of hepatic resection for hepatocellular carcinoma, excessive blood loss and blood transfusion greatly influence postoperative complications and prognosis of the patients. We evaluated the influence of blood products use on postoperative recurrence and prognosis of patients with hepatocellular carcinoma.

Methods

The subjects were 66 patients who underwent elective hepatic resection for hepatocellular carcinoma without concomitant microwave or radiofrequency ablation therapy nor other malignancies between January 2001 and June 2006. We retrospectively investigated the influence of the use of blood products including red cell concentration and fresh frozen plasma on recurrence of hepatocellular carcinoma and overall survival.

Results

In multivariate analysis, the dose of blood products transfusion was a significant predictor of disease-free and overall survival. Both disease-free and overall survival rates of those who were given blood products were significantly worse than those who did not receive. On the other hand, in univariate analysis of disease-free and overall survival after hepatic resection and clinical variables, the amount of blood loss was not a significant predictor of recurrence or death.

Conclusion

Transfusion of blood products is associated with increased recurrence rate and worse survival after elective hepatic resection for patients with hepatocellular carcinoma.

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Title: Negative Impact of Blood Transfusion on Recurrence and Prognosis of Hepatocellular Carcinoma After Hepatic Resection
Authors: Hiroaki Shiba
Yuichi Ishida
Shigeki Wakiyama
Tomonori Iida
Michinori Matsumoto
Taro Sakamoto
Ryusuke Ito
Takeshi Gocho
Kenei Furukawa
Yuki Fujiwara
Shoichi Hirohara
Takeyuki Misawa
Katsuhiko Yanaga
Publication date: 01-09-2009
Publisher: Springer-Verlag
Published in: Journal of Gastrointestinal Surgery / Issue 9/2009
Print ISSN: 1091-255X
Electronic ISSN: 1873-4626
DOI: https://doi.org/10.1007/s11605-009-0963-y

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Negative Impact of Blood Transfusion on Recurrence and Prognosis of Hepatocellular Carcinoma After Hepatic Resection

Abstract

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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