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01-08-2016 | Original Article

NEDD 4 binding protein 2-like 1 promotes cancer cell invasion in oral squamous cell carcinoma

Authors: Tomonori Sasahira, Miyako Kurihara, Yukiko Nishiguchi, Rina Fujiwara, Tadaaki Kirita, Hiroki Kuniyasu

Published in: Virchows Archiv | Issue 2/2016

Abstract

Head and neck cancer, including oral squamous cell carcinoma, is the sixth most common cancer worldwide. Although cancer cell invasion and metastasis are crucial for tumor progression, detailed molecular mechanisms underlying the invasion and metastasis of oral squamous cell carcinoma are unclear. Comparison of transcriptional profiles using a cDNA microarray demonstrated that N4BP2L1, a novel oncogene expressed by neural precursor cells, is involved in oral squamous cell carcinoma. Expression of N4BP2L1 in oral squamous cell carcinoma is regulated by activation of miR-448 and is higher than in normal oral mucosa. Knockdown of N4BP2L1 and upregulation of miR-448 significantly reduced the invasive potential of oral squamous cell carcinoma cells. We studied N4BP2L1 expression in 187 cases of oral squamous cell carcinoma and found its overexpression to be significantly associated with nodal metastasis (P = 0.0155) and poor prognosis (P = 0.0136). Expression of miR-448 was found to be inversely associated with that of N4BP2L1 (P = 0.0019). Cox proportional hazards analysis identified N4BP2L1 expression as an independent predictor of disease-free survival (P = 0.0349). Our results suggest that N4BP2L1 plays an important role in tumor cell invasion in oral squamous cell carcinoma. Further studies on expression of N4BP2L1 may provide new insight into its function and clarify its potential as biomarker in human oral cancer.

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Title: NEDD 4 binding protein 2-like 1 promotes cancer cell invasion in oral squamous cell carcinoma
Authors: Tomonori Sasahira
Miyako Kurihara
Yukiko Nishiguchi
Rina Fujiwara
Tadaaki Kirita
Hiroki Kuniyasu
Publication date: 01-08-2016
Publisher: Springer Berlin Heidelberg
Published in: Virchows Archiv / Issue 2/2016
Print ISSN: 0945-6317
Electronic ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-016-1955-4

At a glance: The STEP trials

Springer Medicine

NEDD 4 binding protein 2-like 1 promotes cancer cell invasion in oral squamous cell carcinoma

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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