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Journal of Medical Case Reports

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Open Access 01-12-2015 | Case report

Necrotizing crescentic glomerulonephritis related to sarcoidosis: a case report

Authors: Natallia Maroz, Halle Field

Published in: Journal of Medical Case Reports | Issue 1/2015

Abstract

Introduction

Renal injury due to sarcoidosis develops in less than a quarter of patients with this systemic disease. In most cases, granulomatous tissue alters the production of vitamin D, which leads to hypercalciuria, nephrocalcinosis, and nephrolithiasis. Granulomatous interstitial nephritis is another well-recognized pathological process associated with sarcoidosis. However, a glomerular pathology is very rarely noted, and only a few cases are reported to have cellular crescentic glomerulonephritis.

Case presentation

We describe the case of a 26-year-old African American woman with systemic sarcoidosis, with a unique constellation of renal lesions, including noncaseating epithelioid granulomatous necrotizing interstitial nephritis, cellular crescent formation, and necrotizing vasculitis. Immunosuppressive therapy was helpful for alleviating her nephrotic syndrome and maintaining the stability of her renal function over a 30-month period.

Conclusion

Glomerular involvement of sarcoidosis needs to be considered in the differential diagnosis in cases of rapidly progressive glomerular nephritis.

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Title: Necrotizing crescentic glomerulonephritis related to sarcoidosis: a case report
Authors: Natallia Maroz
Halle Field
Publication date: 01-12-2015
Publisher: BioMed Central
Published in: Journal of Medical Case Reports / Issue 1/2015
Electronic ISSN: 1752-1947
DOI: https://doi.org/10.1186/s13256-015-0764-8

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Necrotizing crescentic glomerulonephritis related to sarcoidosis: a case report

Abstract

Introduction

Case presentation

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Introduction

Case presentation

Conclusion

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