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European Archives of Oto-Rhino-Laryngology
Published in: European Archives of Oto-Rhino-Laryngology 6/2021

01-06-2021 | Nausea | Head and Neck

The effect of dexamethasone on pain control after thyroid surgery: a meta-analysis of randomized controlled trials

Authors: Lian Cheng, Yuan Le, Hui Yang, Xiangyu Zhou

Published in: European Archives of Oto-Rhino-Laryngology | Issue 6/2021

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Abstract

Introduction

The effect of dexamethasone on postoperative pain after thyroid surgery remains controversial. We conduct a systematic review and meta-analysis to explore the influence of dexamethasone versus placebo on postoperative pain after thyroid surgery.

Methods

We search PubMed, EMbase, Web of science, EBSCO, and Cochrane library databases through May 2020 for randomized controlled trials (RCTs) assessing the effect of dexamethasone versus placebo on postoperative pain after thyroid surgery. This meta-analysis is performed using the random-effect model.

Results

Eight RCTs involving 734 patients are included in the meta-analysis. Overall, compared with control group for thyroid surgery, dexamethasone shows significantly reduced pain scores (SMD = − 0.82; 95% CI − 1.08 to − 0.56; P < 0.00001), number of required analgesics (OR = 0.18; 95% CI 0.11–0.31; P < 0.00001), analgesic consumption (SMD = − 0.38; 95% CI − 0.63 to − 0.13; P = 0.003), nausea and vomiting (OR = 0.38; 95% CI 0.17–0.86; P = 0.02), as well as rescue antiemetics (OR = 0.40; 95% CI 0.20–0.79; P = 0.008).

Conclusions

Perioperative dexamethasone is effective to reduce the pain, nausea and vomiting after thyroid surgery.
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Metadata
Title
The effect of dexamethasone on pain control after thyroid surgery: a meta-analysis of randomized controlled trials
Authors
Lian Cheng
Yuan Le
Hui Yang
Xiangyu Zhou
Publication date
01-06-2021
Publisher
Springer Berlin Heidelberg
Published in
European Archives of Oto-Rhino-Laryngology / Issue 6/2021
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI
https://doi.org/10.1007/s00405-020-06245-8

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