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Published in: Supportive Care in Cancer 3/2021

01-03-2021 | Nausea | Original Article

Creation of a chemotherapy-induced nausea/vomiting dashboard to improve outcomes for pediatric cancer patients

Authors: Alexandra M. Walsh, Jennifer Hess, Melissa Rees, Cynthia Wetmore, Vinay Vadiya

Published in: Supportive Care in Cancer | Issue 3/2021

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Abstract

Purpose

Two of the most common acute side effects of chemotherapy are nausea and vomiting. Nausea and vomiting impact quality of life, nutritional status, and ability to tolerate further chemotherapy. Parents of pediatric oncology patients rank nausea as one of the most bothersome treatment-related symptoms.

Methods

Utilizing Quality Improvement methodology, we developed a dashboard interface to facilitate extraction of data from the electronic medical record (EMR), which is presented via a visual display that summarizes the type of chemotherapy and antiemetic medications, use of as needed medications, and number of episodes of emesis.

Results

This dashboard interface allows for rapid and efficient identification of patients whose antiemetic regimen is mismatched for the emetogenicity of ordered chemotherapy, thus providing a timely opportunity to modify the antiemetic regimen based on published guidelines before administration of chemotherapy drugs. It also allows measurement of the effectiveness of the antiemetic regimen in terms of the number of break through emesis and the need for as needed medications.

Conclusions

A novel CINV dashboard was created, which visually conveys complex information about antiemetics, chemotherapy emetogenicity, as needed medications, and breakthrough vomiting for inpatient pediatric oncology patients.
Literature
2.
go back to reference Clemmons AB, Orr J, Andrick B, Gandhi A, Sportes C, DeRemer D (2018) Randomized, placebo-controlled, phase III trial of Fosaprepitant, Ondansetron, Dexamethasone (FOND) versus FOND plus olanzapine (FOND-O) for the prevention of chemotherapy-induced nausea and vomiting in patients with hematologic malignancies receiving highly emetogenic chemotherapy and hematopoietic cell transplantation regimens: the FOND-O trial. Biol Blood Marrow Transplant 24:2065–2071. https://doi.org/10.1016/j.bbmt.2018.06.005CrossRefPubMed Clemmons AB, Orr J, Andrick B, Gandhi A, Sportes C, DeRemer D (2018) Randomized, placebo-controlled, phase III trial of Fosaprepitant, Ondansetron, Dexamethasone (FOND) versus FOND plus olanzapine (FOND-O) for the prevention of chemotherapy-induced nausea and vomiting in patients with hematologic malignancies receiving highly emetogenic chemotherapy and hematopoietic cell transplantation regimens: the FOND-O trial. Biol Blood Marrow Transplant 24:2065–2071. https://​doi.​org/​10.​1016/​j.​bbmt.​2018.​06.​005CrossRefPubMed
4.
go back to reference Dupuis LL, Boodhan S, Holdsworth M, Robinson PD, Hain R, Portwine C, O'Shaughnessy E, Sung L, Pediatric Oncology Group of O (2013) Guideline for the prevention of acute nausea and vomiting due to antineoplastic medication in pediatric cancer patients. Pediatr Blood Cancer 60(7):1073–1082. https://doi.org/10.1002/pbc.24508CrossRefPubMed Dupuis LL, Boodhan S, Holdsworth M, Robinson PD, Hain R, Portwine C, O'Shaughnessy E, Sung L, Pediatric Oncology Group of O (2013) Guideline for the prevention of acute nausea and vomiting due to antineoplastic medication in pediatric cancer patients. Pediatr Blood Cancer 60(7):1073–1082. https://​doi.​org/​10.​1002/​pbc.​24508CrossRefPubMed
5.
go back to reference Aapro M, Rugo H, Rossi G, Rizzi G, Borroni ME, Bondarenko I, Sarosiek T, Oprean C, Cardona-Huerta S, Lorusso V, Karthaus M, Schwartzberg L, Grunberg S (2014) A randomized phase III study evaluating the efficacy and safety of NEPA, a fixed-dose combination of netupitant and palonosetron, for prevention of chemotherapy-induced nausea and vomiting following moderately emetogenic chemotherapy. Ann Oncol 25(7):1328–1333. https://doi.org/10.1093/annonc/mdu101CrossRefPubMedPubMedCentral Aapro M, Rugo H, Rossi G, Rizzi G, Borroni ME, Bondarenko I, Sarosiek T, Oprean C, Cardona-Huerta S, Lorusso V, Karthaus M, Schwartzberg L, Grunberg S (2014) A randomized phase III study evaluating the efficacy and safety of NEPA, a fixed-dose combination of netupitant and palonosetron, for prevention of chemotherapy-induced nausea and vomiting following moderately emetogenic chemotherapy. Ann Oncol 25(7):1328–1333. https://​doi.​org/​10.​1093/​annonc/​mdu101CrossRefPubMedPubMedCentral
9.
go back to reference Polito S, MacDonald T, Romanick M, Jupp J, Wiernikowski J, Vennettilli A, Khanna M, Patel P, Ning W, Sung L, Dupuis LL (2018) Safety and efficacy of nabilone for acute chemotherapy-induced vomiting prophylaxis in pediatric patients: a multicenter, retrospective review. Pediatr Blood Cancer 65(12):e27374. https://doi.org/10.1002/pbc.27374CrossRefPubMed Polito S, MacDonald T, Romanick M, Jupp J, Wiernikowski J, Vennettilli A, Khanna M, Patel P, Ning W, Sung L, Dupuis LL (2018) Safety and efficacy of nabilone for acute chemotherapy-induced vomiting prophylaxis in pediatric patients: a multicenter, retrospective review. Pediatr Blood Cancer 65(12):e27374. https://​doi.​org/​10.​1002/​pbc.​27374CrossRefPubMed
10.
go back to reference Medicine IIo (2011) Clinical practice guidelines we can trust: committee on standards for developing trustworthy clinical practice guidelines. The National Academies Press, Washington DC Medicine IIo (2011) Clinical practice guidelines we can trust: committee on standards for developing trustworthy clinical practice guidelines. The National Academies Press, Washington DC
13.
15.
go back to reference Aapro M, Molassiotis A, Dicato M, Peláez I, Rodríguez-Lescure Á, Pastorelli D, Ma L, Burke T, Gu A, Gascon P, Roila F, investigators P (2012) The effect of guideline-consistent antiemetic therapy on chemotherapy-induced nausea and vomiting (CINV): the Pan European Emesis Registry (PEER). Ann Oncol 23(8):1986–1992. https://doi.org/10.1093/annonc/mds021CrossRefPubMed Aapro M, Molassiotis A, Dicato M, Peláez I, Rodríguez-Lescure Á, Pastorelli D, Ma L, Burke T, Gu A, Gascon P, Roila F, investigators P (2012) The effect of guideline-consistent antiemetic therapy on chemotherapy-induced nausea and vomiting (CINV): the Pan European Emesis Registry (PEER). Ann Oncol 23(8):1986–1992. https://​doi.​org/​10.​1093/​annonc/​mds021CrossRefPubMed
22.
go back to reference Battjes R, Jones L, Groves C, Fakih M (2017) An innovative approach to evaluate hospital and system improvements in infection prevention: development of a dynamic bacteremia dashboard. Am J Infect Control 45(6):S46CrossRef Battjes R, Jones L, Groves C, Fakih M (2017) An innovative approach to evaluate hospital and system improvements in infection prevention: development of a dynamic bacteremia dashboard. Am J Infect Control 45(6):S46CrossRef
24.
go back to reference Shaw SJ, Jacobs B, Stockwell DC, Futterman C, Spaeder MC (2015) Effect of a real-time pediatric ICU safety bundle dashboard on quality improvement measures. Jt Comm J Qual Patient Saf 41(9):414–420PubMed Shaw SJ, Jacobs B, Stockwell DC, Futterman C, Spaeder MC (2015) Effect of a real-time pediatric ICU safety bundle dashboard on quality improvement measures. Jt Comm J Qual Patient Saf 41(9):414–420PubMed
25.
go back to reference Hagland M (2010) First place. Children's Hospital of Pittsburgh. Improving patient care through data availability in the ICU. Healthc inform 27(3):20–21 23, 26 passimPubMed Hagland M (2010) First place. Children's Hospital of Pittsburgh. Improving patient care through data availability in the ICU. Healthc inform 27(3):20–21 23, 26 passimPubMed
33.
go back to reference Flank J, Nadeem K, Moledina S, Khanna M, Schindera C, Punnett A, Dupuis LL (2017) Nausea and vomiting in children and adolescents receiving intrathecal methotrexate: a prospective, observational study. Pediatr Blood Cancer 64(10). https://doi.org/10.1002/pbc.26603 Flank J, Nadeem K, Moledina S, Khanna M, Schindera C, Punnett A, Dupuis LL (2017) Nausea and vomiting in children and adolescents receiving intrathecal methotrexate: a prospective, observational study. Pediatr Blood Cancer 64(10). https://​doi.​org/​10.​1002/​pbc.​26603
Metadata
Title
Creation of a chemotherapy-induced nausea/vomiting dashboard to improve outcomes for pediatric cancer patients
Authors
Alexandra M. Walsh
Jennifer Hess
Melissa Rees
Cynthia Wetmore
Vinay Vadiya
Publication date
01-03-2021
Publisher
Springer Berlin Heidelberg
Published in
Supportive Care in Cancer / Issue 3/2021
Print ISSN: 0941-4355
Electronic ISSN: 1433-7339
DOI
https://doi.org/10.1007/s00520-020-05652-1

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