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Langenbeck's Archives of Surgery

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01-09-2019 | Nausea | Original Article

Impact of drains on nausea and vomiting after thyroid and parathyroid surgery: a randomized controlled trial

Authors: B. M. Künzli, M. Walensi, J. Wilimsky, C. Bucher, T. Bührer, C. Kull, A. Zuse, C. A. Maurer

Published in: Langenbeck's Archives of Surgery | Issue 6/2019

Abstract

Objective

Nausea and vomiting are common side effects following thyroid and parathyroid surgery. In a prospective controlled randomized trial, postoperative nausea and vomiting (PONV) and the number of episodes of vomiting were defined as two primary endpoints. We analysed whether the placement of drains after thyroid or parathyroid surgery enhances PONV and/or influences vomiting.

Patients and methods

From November 2007 to January 2012, 136 consecutive patients were included for thyroid or parathyroid surgery and were randomly assigned to group A (drain, n = 69) or group B (no drain, n = 67). PONV was assessed with visual analogue scale (VAS; range 0 to 10) measurements. Furthermore, episodes of vomiting as well as analgetic and antiemetic therapies were recorded. Difference in neck circumference was compared pre- and postoperatively.

Results

Patients’ characteristics did not differ between group A and B. Postoperative VAS values for pain were 2.4 ± 0.3 (group A) and 2.6 ± 0.2 (group B) (p = 0.62), and for nausea 1.4 ± 0.2 (group A) and 1.1 ± 0.2 (group B) (p = 0.57). The relative occurrences of episodes for postoperative vomiting were equal in both groups 0.3 ± 0.1 (p = 1.0). Antiemetic drugs were administered 37 times (group A) and 18 times (group B) (p = 0.099). The total number of treatments of patients with antiemetic drugs was 23 (33.3%) in group A vs. 13 (19.4%) in group B (p = 0.081). The neck circumference postoperatively was significantly larger in group B (p = 0.0025).

Conclusions

Drains after surgery do not enhance postoperative pain, nausea and vomiting. The placement of drains in thyroid surgery is recommended to avoid relevant fluid collection. Drains however may influence the amount of antiemetic drug requirements.

Trial registration

ClinicalTrials.gov Identifier: NCT01679418

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Title: Impact of drains on nausea and vomiting after thyroid and parathyroid surgery: a randomized controlled trial
Authors: B. M. Künzli
M. Walensi
J. Wilimsky
C. Bucher
T. Bührer
C. Kull
A. Zuse
C. A. Maurer
Publication date: 01-09-2019
Publisher: Springer Berlin Heidelberg
Keywords: Nausea
Thyroid and Parathyroid Surgery
Vomiting
Postoperative Nausea and Vomiting
Thyroid and Parathyroid Surgery
Antiemetic Therapy
Thyroidectomy
Thyroidectomy
Published in: Langenbeck's Archives of Surgery / Issue 6/2019
Print ISSN: 1435-2443
Electronic ISSN: 1435-2451
DOI: https://doi.org/10.1007/s00423-019-01799-6

At a glance: The STEP trials

Springer Medicine

Impact of drains on nausea and vomiting after thyroid and parathyroid surgery: a randomized controlled trial

Abstract

Objective

Patients and methods

Results

Conclusions

Trial registration

ClinicalTrials.gov Identifier: NCT01679418

At a glance: The STEP trials

Springer Medicine

Abstract

Objective

Patients and methods

Results

Conclusions

Trial registration

ClinicalTrials.​gov Identifier: NCT01679418

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