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Published in:

01-08-2013 | Review

Natural killer cells in human autoimmune disorders

Authors: Leslie A Fogel, Wayne M Yokoyama, Anthony R French

Published in: Arthritis Research & Therapy | Issue 4/2013

Abstract

Natural killer (NK) cells are innate lymphocytes that play a critical role in early host defense against viruses. Through their cytolytic capacity and generation of cytokines and chemokines, NK cells modulate the activity of other components of the innate and adaptive immune systems and have been implicated in the initiation or maintenance of autoimmune responses. This review focuses on recent research elucidating a potential immunoregulatory role for NK cells in T-cell and B-cell-mediated autoimmune disorders in humans, with a particular focus on multiple sclerosis, rheumatoid arthritis, and systemic lupus erythematous. A better understanding of the contributions of NK cells to the development of autoimmunity may lead to novel therapeutic targets in these diseases.

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Title: Natural killer cells in human autoimmune disorders
Authors: Leslie A Fogel
Wayne M Yokoyama
Anthony R French
Publication date: 01-08-2013
Publisher: BioMed Central
Published in: Arthritis Research & Therapy / Issue 4/2013
Electronic ISSN: 1478-6362
DOI: https://doi.org/10.1186/ar4232

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