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01-10-2014 | Original Article

Nationwide population-based cohort study on the association of acute coronary syndrome in patients with malignancies

Authors: Yen-Nien Lin, Yen-Jung Chang, Yin-Huei Chen, Po-Yen Ko, Cheng-Li Lin, Fung-Chang Sung, Kuan-Cheng Chang, Chia-Hung Kao

Published in: Supportive Care in Cancer | Issue 10/2014

Abstract

Aims/introduction

Patients with malignancy are suggestive of having a tendency toward an association with vascular thrombosis risk. The aim of this study was to evaluate the possible relationship between malignancy and the risk of acute coronary syndrome (ACS) in Taiwan.

Materials and methods

We used data from the National Health Insurance (NHI) system of Taiwan to assess the issue. Cox proportional hazards regression analysis was conducted to estimate the effects of malignancy on the risk of ACS.

Results

ACS risk in patients with malignancies was marginally significantly greater when adjusted for age, sex (hazard ratio (HR) = 1.09, 95 % confidence interval (CI) = 0.99–1.20), and comorbidities (HR = 1.03, 95 % CI = 0.93–1.13). A subgroup analysis indicated that patients with prostate cancer and head and neck cancer (HEENT) had a significantly higher risk of ACS (HR = 1.30, 95 % CI = 1.01–1.67; HR = 3.03, 95 % CI = 1.47–6.50).

Conclusions

We suggest careful surveillance of ACS symptoms and regular electrocardiography during follow-up of these patients. However, further large-scale studies for patients with prostate and HEENT cancer and cancer survivors (especially from post-hormone or radiotherapy) are needed.

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Title: Nationwide population-based cohort study on the association of acute coronary syndrome in patients with malignancies
Authors: Yen-Nien Lin
Yen-Jung Chang
Yin-Huei Chen
Po-Yen Ko
Cheng-Li Lin
Fung-Chang Sung
Kuan-Cheng Chang
Chia-Hung Kao
Publication date: 01-10-2014
Publisher: Springer Berlin Heidelberg
Published in: Supportive Care in Cancer / Issue 10/2014
Print ISSN: 0941-4355
Electronic ISSN: 1433-7339
DOI: https://doi.org/10.1007/s00520-014-2262-8

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Abstract

Aims/introduction

Materials and methods

Results

Conclusions

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