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BMC Pediatrics
Published in: BMC Pediatrics 1/2016

Open Access 01-12-2016 | Research article

Nasal carriage of common bacterial pathogens among healthy kindergarten children in Chaoshan region, southern China: a cross-sectional study

Authors: Hui Pan, Binglin Cui, Yuanchun Huang, Jiacai Yang, William Ba-Thein

Published in: BMC Pediatrics | Issue 1/2016

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Abstract

Background

Nasal colonization with bacterial pathogens is associated with risk of invasive respiratory tract infections, but the related information for Chinese healthy children is scarce.

Methods

This cross-sectional study was conducted with healthy children from 6 kindergartens in the Chaoshan region, southern China during 2011–2012. Nasal swabs were examined for five common bacterial pathogens: Streptococcus pneumoniae, Haemophilus influenzae, Haemophilus parainfluenzae, Moraxella catarrhalis, and Staphylococcus aureus.

Results

Among 1,088 children enrolled, 79.6 % (866) were target-bacterial carriers, of which 34.4 % (298/866) were positive for ≥2 bacteria species. The most common pathogen in the bacterial carriers was M. catarrhalis (76.6 %), followed by S. pneumoniae (26.6 %), S. aureus (21.8 %), H. parainfluenzae (12.7 %), and H. influenzae (2.3 %). Multiple logistic regression analyses showed negative associations between age and the overall or multiple bacterial carriage, and between the father’s education level and multiple bacterial carriage (all p < 0.05). Age was negatively associated with the carriage of M. catarrhalis and S. pneumoniae, and positively associated with the S. aureus carriage (all p < 0.0001).

Conclusions

This study shows high nasal carriage of common pathogenic bacteria and coexistence of multiple pathogens in healthy Chaoshan kindergarten children, with M. catarrhalis as the commonest colonizer. Increasing age of children and higher paternal education are associated with lower risk of bacterial carriage. Longitudinal follow-up studies would be helpful for better understanding the infection risk in bacterial pathogen carriers.
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Literature
1.
O'Brien KL, Wolfson LJ, Watt JP, Henkle E, Deloria-Knoll M, McCall N, Lee E, Mulholland K, Levine OS, Cherian T, et al. Burden of disease caused by Streptococcus pneumoniae in children younger than 5 years: global estimates. Lancet. 2009;374(9693):893–902.CrossRefPubMed
2.
World Health O. WHO position paper on Haemophilus influenzae type b conjugate vaccines. (Replaces WHO position paper on Hib vaccines previously published in the Weekly Epidemiological Record). Releve epidemiologique hebdomadaire/Section d'hygiene du Secretariat de la Societe des Nations = Weekly epidemiological record/Health Section of the Secretariat of the League of Nations. 2006;81(47):445–52.
3.
Biedenbach DJ, Jones RN, Pfaller MA, Sentry Participants G. Activity of BMS284756 against 2,681 recent clinical isolates of Haemophilus influenzae and Moraxella catarrhalis: Report from The SENTRY Antimicrobial Surveillance Program (2000) in Europe, Canada and the United States. Diagn Microbiol Infect Dis. 2001;39(4):245–50.CrossRefPubMed
4.
Johnson DM, Sader HS, Fritsche TR, Biedenbach DJ, Jones RN. Susceptibility trends of haemophilus influenzae and Moraxella catarrhalis against orally administered antimicrobial agents: five-year report from the SENTRY Antimicrobial Surveillance Program. Diagn Microbiol Infect Dis. 2003;47(1):373–6.CrossRefPubMed
5.
Waters D, Jawad I, Ahmad A, Luksic I, Nair H, Zgaga L, Theodoratou E, Rudan I, Zaidi AK, Campbell H. Aetiology of community-acquired neonatal sepsis in low and middle income countries. Journal of global health. 2011;1(2):154–70.PubMedPubMedCentral
6.
Wertheim HF, Melles DC, Vos MC, van Leeuwen W, van Belkum A, Verbrugh HA, Nouwen JL. The role of nasal carriage in Staphylococcus aureus infections. Lancet Infect Dis. 2005;5(12):751–62.CrossRefPubMed
7.
Garcia-Rodriguez JA, Fresnadillo Martinez MJ. Dynamics of nasopharyngeal colonization by potential respiratory pathogens. J Antimicrob Chemother. 2002;50(Suppl S2):59–73.CrossRefPubMed
8.
Diavatopoulos DA, Short KR, Price JT, Wilksch JJ, Brown LE, Briles DE, Strugnell RA, Wijburg OL. Influenza A virus facilitates Streptococcus pneumoniae transmission and disease. FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology. 2010;24(6):1789–98.CrossRef
9.
Adegbola RA, DeAntonio R, Hill PC, Roca A, Usuf E, Hoet B, Greenwood BM. Carriage of Streptococcus pneumoniae and other respiratory bacterial pathogens in low and lower-middle income countries: a systematic review and meta-analysis. PLoS One. 2014;9(8):e103293.CrossRefPubMedPubMedCentral
10.
Leach AJ, Boswell JB, Asche V, Nienhuys TG, Mathews JD. Bacterial colonization of the nasopharynx predicts very early onset and persistence of otitis media in Australian aboriginal infants. Pediatr Infect Dis J. 1994;13(11):983–9.CrossRefPubMed
11.
12.
13.
14.
15.
Liu L, Xie W, Jing C. Survey of respiratory tract microbial population in children. Chinese Journal of Microecology. 2007;19(1):22–6.
16.
Naaber P, Tamm E, Putsepp A, Koljalg S, Maimets M. Nasopharyngeal carriage and antibacterial susceptibility of Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis in Estonian children. Clin Microbiol Infect. 2000;6(12):675–7.CrossRefPubMed
17.
Zemlickova H, Urbaskova P, Adamkova V, Motlova J, Lebedova V, Prochazka B. Characteristics of Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis and Staphylococcus aureus isolated from the nasopharynx of healthy children attending day-care centres in the Czech Republic. Epidemiol Infect. 2006;134(6):1179–87.CrossRefPubMedPubMedCentral
18.
Quinones D, Llanes R, Torano G, Perez M. Nasopharyngeal colonization by Moraxella catarrhalis and study of antimicrobial susceptibility in healthy children from Cuban day-care centers. Arch Med Res. 2005;36(1):80–2.CrossRefPubMed
19.
Jourdain S, Smeesters PR, Denis O, Dramaix M, Sputael V, Malaviolle X, Van Melderen L, Vergison A. Differences in nasopharyngeal bacterial carriage in preschool children from different socio-economic origins. Clin Microbiol Infect. 2011;17(6):907–14.CrossRefPubMed
20.
Bae S, Yu JY, Lee K, Lee S, Park B, Kang Y. Nasal colonization by four potential respiratory bacteria in healthy children attending kindergarten or elementary school in Seoul, Korea. J Med Microbiol. 2012;61(Pt 5):678–85.CrossRefPubMed
21.
Luo X, Liang J, Gao S, Li Z, Zhou R. Surveys on bacteria nasopharyngeal carriage prevalence in 186 children. Chinese Journal of Microecology. 2006;18(3):204–8.
22.
23.
Obaro S, Adegbola R. The pneumococcus: carriage, disease and conjugate vaccines. J Med Microbiol. 2002;51(2):98–104.CrossRefPubMed
24.
Fontanals D, Bou R, Pons I, Sanfeliu I, Dominguez A, Pineda V, Renau J, Munoz C, Latorre C, Sanchez F. Prevalence of Haemophilus influenzae carriers in the Catalan preschool population. Working Group on Invasive Disease Caused by Haemophilus influenzae. European Journal of Clinical Microbiology & Infectious Diseases: Official Publication of the European Society of Clinical Microbiology. 2000;19(4):301–4.CrossRef
25.
Ho PL, Chiu SS, Chan MY, Gan Y, Chow KH, Lai EL, Lau YL. Molecular epidemiology and nasal carriage of Staphylococcus aureus and methicillin-resistant S. aureus among young children attending day care centers and kindergartens in Hong Kong. J Infect. 2012;64(5):500–6.CrossRefPubMed
26.
Thummeepak R, Leerach N, Kunthalert D, Tangchaisuriya U, Thanwisai A, Sitthisak S. High prevalence of multi-drug resistant Streptococcus pneumoniae among healthy children in Thailand. J Infect Public Health. 2015;8(3):274–81.CrossRefPubMed
27.
Jacoby P, Watson K, Bowman J, Taylor A, Riley TV, Smith DW, Lehmann D, Kalgoorlie Otitis Media Research Project T. Modelling the co-occurrence of Streptococcus pneumoniae with other bacterial and viral pathogens in the upper respiratory tract. Vaccine. 2007;25(13):2458–64.CrossRefPubMed
28.
Kwambana BA, Barer MR, Bottomley C, Adegbola RA, Antonio M. Early acquisition and high nasopharyngeal co-colonisation by Streptococcus pneumoniae and three respiratory pathogens amongst Gambian new-borns and infants. BMC Infect Dis. 2011;11:175.CrossRefPubMedPubMedCentral
29.
Syrjanen RK, Auranen KJ, Leino TM, Kilpi TM, Makela PH. Pneumococcal acute otitis media in relation to pneumococcal nasopharyngeal carriage. Pediatr Infect Dis J. 2005;24(9):801–6.CrossRefPubMed
30.
Faden H, Duffy L, Wasielewski R, Wolf J, Krystofik D, Tung Y. Relationship between nasopharyngeal colonization and the development of otitis media in children. Tonawanda/Williamsville Pediatrics. J Infect Dis. 1997;175(6):1440–5.CrossRefPubMed
31.
Han J, Lin J, Lin L, Zou Q. Monitoring of disinfection quality in kindergartens of Guangdong province. Chinese Journal of Disinfection. 2009;26(4):414–6.
32.
Huang J, Jiang S, Xie G, Chen H, Li X. The monitoring results of disinfection quality in kindergartens, Shantou in 2003–2005. South China J Prev Med. 2007;33(1):69–70.
33.
Ma H, Zheng Z, Yang S. Investigation on disinfection quality of 81 kindergartens in Wolong district, Nanyang City. J Med Theor & Prac. 2012;25(10):1254–5.
34.
Yang YH, Fu SG, Peng H, Shen AD, Yue SJ, Go YF, Yuan L, Jiang ZF. Abuse of antibiotics in China and its potential interference in determining the etiology of pediatric bacterial diseases. Pediatr Infect Dis J. 1993;12(12):986–8.CrossRefPubMed
35.
Liang X, Jin C, Wang L, Wei L, Tomson G, Rehnberg C, Wahlstrom R, Petzold M. Unnecessary use of antibiotics for inpatient children with pneumonia in two counties of rural China. Int J Clin Pharm. 2011;33(5):750–4.CrossRefPubMed
Metadata
Title
Nasal carriage of common bacterial pathogens among healthy kindergarten children in Chaoshan region, southern China: a cross-sectional study
Authors
Hui Pan
Binglin Cui
Yuanchun Huang
Jiacai Yang
William Ba-Thein
Publication date
01-12-2016
Publisher
BioMed Central
Published in
BMC Pediatrics / Issue 1/2016
Electronic ISSN: 1471-2431
DOI
https://doi.org/10.1186/s12887-016-0703-x

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