Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
Breast Cancer Research
Published in: Breast Cancer Research 2/2011

01-04-2011 | Viewpoint

Nanomedicine: making controllable magnetic drug delivery possible for the treatment of breast cancer

Authors: Lesa A Tran, Lon J Wilson

Published in: Breast Cancer Research | Issue 2/2011

Login to get access

Abstract

A recent study published in Nano Letters documents the synthesis and performance of porous silica nanocapsules filled with magnetic nanoparticles as a controllable magnetic drug delivery vector. Under a remotely applied radiofrequency magnetic field, these nanocapsules demonstrate on-off switchable release of the internally loaded drug payload. Both in vitro and in vivo studies using MT2 mouse breast cancer cell models demonstrate that the magnetic targeting of these nanocapsules allows for deep tumor penetration and subsequent on-demand release of the drug cargo, significantly reducing tumor cell viability.
Literature
1.
Kim BYS, Rutka JT, Chan WCW: Current concepts: nanomedicine. N Engl J Med. 2010, 363: 2434-2443. 10.1056/NEJMra0912273.CrossRefPubMed
2.
Cuenca AG, Jiang H, Hochwald SN, Delano M, Cance WG, Grobmyer SR: Emerging implications of nanotechnology on cancer diagnostics and therapeutics. Cancer. 2006, 107: 459-466. 10.1002/cncr.22035.CrossRefPubMed
3.
Arruebo M, Fernández-Pacheco R, Ibarra MR, Santamaría J: Magnetic nanoparticles for drug delivery. Nano Today. 2007, 2: 22-32. 10.1016/S1748-0132(07)70084-1.CrossRef
4.
Klostergaard J, Bankson J, Auzenne E, Gibson D, Yuill W, Seeney CE: Magnetic vectoring of magnetically responsive nanoparticles within the murine peritoneum. J Magn Magn Mater. 2007, 311: 330-335. 10.1016/j.jmmm.2006.10.1163.CrossRef
5.
Hoare R, Santamaria J, Goya GF, Irusta S, Lin D, Lau S, Padera R, Langer R, Kohane DS: A magnetically triggered composite membrane for on-demand drug delivery. Nano Lett. 2009, 9: 3651-3657. 10.1021/nl9018935.CrossRefPubMedPubMedCentral
6.
Thomas CR, Ferris DP, Lee J-H, Choi E, Cho MH, Kim ES, Stoddart JF, Shin J-S, Cheon J, Zink JI: Noninvasive remote-controlled release of drug molecules in vitro using magnetic actuation of mechanized nanoparticles. J Am Chem Soc. 2010, 132: 10623-10625. 10.1021/ja1022267.CrossRefPubMed
7.
Kong SD, Zhang W, Lee JH, Brammer K, Lal R, Karin M, Jin S: Magnetically vectored nanocapsules for tumor penetration and remotely switchable on-demand drug release. Nano Lett. 2010, 10: 5088-5092. [Epub ahead of print]CrossRefPubMed
8.
Hilger I, Hergt R, Kaiser WA: Use of magnetic nanoparticle heating in the treatment of breast cancer. IEE Proc Nanobiotechnol. 2005, 152: 33-39. 10.1049/ip-nbt:20055018.CrossRefPubMed
9.
Kempe H, Kempe M: The use of magnetite nanoparticles for implant-assisted magnetic drug targeting in thrombolytic therapy. Biomaterials. 2010, 31: 9499-9510. 10.1016/j.biomaterials.2010.07.107.CrossRefPubMed
Metadata
Title
Nanomedicine: making controllable magnetic drug delivery possible for the treatment of breast cancer
Authors
Lesa A Tran
Lon J Wilson
Publication date
01-04-2011
Publisher
BioMed Central
Published in
Breast Cancer Research / Issue 2/2011
Electronic ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr2830

Other articles of this Issue 2/2011

Breast Cancer Research 2/2011 Go to the issue

Research article

Exploring the link between MORF4L1 and risk of breast cancer

Research article

Ki-67 can be used for further classification of triple negative breast cancer into two subtypes with different response and prognosis

Research article

Adipokines, insulin resistance, metabolic syndrome, and breast cancer recurrence: a cohort study

Research article

Estrogen receptor beta inhibits transcriptional activity of hypoxia inducible factor-1 through the downregulation of arylhydrocarbon receptor nuclear translocator

Research article

Trastuzumab-DM1 causes tumour growth inhibition by mitotic catastrophe in trastuzumab-resistant breast cancer cells in vivo

Research article

Fulvestrant-induced expression of ErbB3 and ErbB4 receptors sensitizes oestrogen receptor-positive breast cancer cells to heregulin β1
Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Watch now

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras
Prof. Fabrice Barlesi
Developed by: Springer Medicine
Image Credits