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BMC Cancer
Published in: BMC Cancer 1/2018

Open Access 01-12-2018 | Review

N-cadherin in cancer metastasis, its emerging role in haematological malignancies and potential as a therapeutic target in cancer

Authors: Krzysztof Marek Mrozik, Orest William Blaschuk, Chee Man Cheong, Andrew Christopher William Zannettino, Kate Vandyke

Published in: BMC Cancer | Issue 1/2018

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Abstract

In many types of solid tumours, the aberrant expression of the cell adhesion molecule N-cadherin is a hallmark of epithelial-to-mesenchymal transition, resulting in the acquisition of an aggressive tumour phenotype. This transition endows tumour cells with the capacity to escape from the confines of the primary tumour and metastasise to secondary sites. In this review, we will discuss how N-cadherin actively promotes the metastatic behaviour of tumour cells, including its involvement in critical signalling pathways which mediate these events. In addition, we will explore the emerging role of N-cadherin in haematological malignancies, including bone marrow homing and microenvironmental protection to anti-cancer agents. Finally, we will discuss the evidence that N-cadherin may be a viable therapeutic target to inhibit cancer metastasis and increase tumour cell sensitivity to existing anti-cancer therapies.
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Metadata
Title
N-cadherin in cancer metastasis, its emerging role in haematological malignancies and potential as a therapeutic target in cancer
Authors
Krzysztof Marek Mrozik
Orest William Blaschuk
Chee Man Cheong
Andrew Christopher William Zannettino
Kate Vandyke
Publication date
01-12-2018
Publisher
BioMed Central
Published in
BMC Cancer / Issue 1/2018
Electronic ISSN: 1471-2407
DOI
https://doi.org/10.1186/s12885-018-4845-0

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