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01-08-2004 | Commentary

N-acetylcysteine in clinical sepsis: a difficult marriage

Author: Herbert Spapen

Published in: Critical Care | Issue 4/2004

Abstract

The high morbidity and mortality of severe sepsis and septic shock fosters a continuous search for novel therapies that go beyond pure correction of oxygenation and hemodynamics. Within this scope, N-acetylcysteine shows great promise. Beside proven anti-oxidant, anti-inflammatory and cytoprotective effects, N-acetylcysteine does also ensure endothelial protection and enhances microvascular blood flow. Studies that put these highly favourable properties to the clinical test remain scarce but are definitely needed to determine whether N-acetylcysteine has a place in our therapeutic armamentarium against sepsis.

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Title: N-acetylcysteine in clinical sepsis: a difficult marriage
Author: Herbert Spapen
Publication date: 01-08-2004
Publisher: BioMed Central
Published in: Critical Care / Issue 4/2004
Electronic ISSN: 1364-8535
DOI: https://doi.org/10.1186/cc2887

Keynote webinar | Spotlight on medication adherence

Springer Medicine

N-acetylcysteine in clinical sepsis: a difficult marriage

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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