Published in:
01-03-2022 | Myocarditis | Image of the Month
68Ga-DOTATOC digital-PET imaging of inflammatory cell infiltrates in myocarditis following COVID-19 vaccination
Authors:
Caroline Boursier, Elodie Chevalier, Laura Filippetti, Laetitia Imbert, Veronique Roch, Olivier Huttin, Marine Claudin, Pierre-Yves Marie
Published in:
European Journal of Nuclear Medicine and Molecular Imaging
|
Issue 4/2022
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Excerpt
Acute myocarditis was recently reported after mRNA COVID-19 vaccination. Here we present images from two male (18 and 21 years old) patients that were recorded with a digital-PET/CT system (Vereos, Philips) 1 h after the injection of 2 MBq/kg of 68 Ga-DOTATOC, as part of an ongoing clinical study (NCT03347760 on ClinicalTrials.gov). Both patients experienced myocarditis 2 to 3 days after the second dose of an mRNA COVID-19 vaccine (Moderna and Pfizer, respectively) and fulfilled the cardiovascular magnetic resonance 2018 Lake Louise criteria for myocarditis, associated with increased plasma troponin (peak troponin: 771 ng/L and 10 830 ng/L) but normal plasma fibrinogen. Plasma C-reactive protein was increased in the 21-year-old patient (41 mg/L). …
