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Open Access 01-12-2011 | Research

Myocardial perfusion imaging with ^{99 m}Tc - tetrofosmin SPECT in breast cancer patients that received postoperative radiotherapy: a case-control study

Authors: Chrissa Sioka, Thomas Exarchopoulos, Ifigenia Tasiou, Eftychia Tzima, Nikolaos Fotou, Antonio Capizzello, Vasilios Ragos, Periklis Tsekeris, Andreas Fotopoulos

Published in: Radiation Oncology | Issue 1/2011

Abstract

Purpose

To evaluate the cardiac toxicity of radiotherapy (RT) in breast cancer (BC) patients employing myocardial perfusion imaging (MPI) with Tc-99 m Tetrofosmin - single photon emission computer tomography (T-SPECT).

Materials and methods

We studied 46 BC female patients (28 patients with left and 18 patients with right BC) treated with postoperative RT compared to a control group of 85 age-matched females. The median time of RT to SPECT was 40 months (6-263).

Results

Abnormalities in the summed stress score (SSS) were found in 54% of left BC patients, 44.4% of right BC patients, and 32.9% of controls. In left BC patients there were significantly more SSS abnormalities compared to controls (4.0 ± 3.5 vs 2.6 ± 2.0, p = 0.05) and possible trend of increased abnormalities of right BC patients (3.7 ± 3.0 vs 2.6 ± 2.0, p = 0.14). Multiple regression analysis showed more abnormalities in the MPI of left BC patients compared to controls (SSS, p = 0.0001); Marginal toxicity was also noted in right BC patients (SSS, p = 0.045). No additional toxicity was found in patients that received adjuvant cardiotoxic chemotherapy. All T-SPECT abnormalities were clinically silent.

Conclusion

The study suggests that radiation therapy to BC patients result in MPI abnormalities but without apparent clinical consequences.

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Title: Myocardial perfusion imaging with 99 mTc - tetrofosmin SPECT in breast cancer patients that received postoperative radiotherapy: a case-control study
Authors: Chrissa Sioka
Thomas Exarchopoulos
Ifigenia Tasiou
Eftychia Tzima
Nikolaos Fotou
Antonio Capizzello
Vasilios Ragos
Periklis Tsekeris
Andreas Fotopoulos
Publication date: 01-12-2011
Publisher: BioMed Central
Published in: Radiation Oncology / Issue 1/2011
Electronic ISSN: 1748-717X
DOI: https://doi.org/10.1186/1748-717X-6-151

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Myocardial perfusion imaging with ^{99 m}Tc - tetrofosmin SPECT in breast cancer patients that received postoperative radiotherapy: a case-control study

Abstract

Purpose

Materials and methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Materials and methods

Results

Conclusion

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