Skip to main content
Top
Published in: American Journal of Clinical Dermatology 5/2006

01-10-2006 | Review Article

Mycetoma

A Review

Authors: Vanessa Lichon, Dr Amor Khachemoune

Published in: American Journal of Clinical Dermatology | Issue 5/2006

Login to get access

Abstract

Mycetoma is a chronic granulomatous infection that is present worldwide and endemic in tropical and subtropical regions. The infection is caused by the traumatic inoculation of a fungus (eumycetoma) or a bacterium (actinomycetoma) and generally remains localized, causing cutaneous and subcutaneous tissue swelling, nodule formation, and drainage through sinus tracts. This review details the history of mycetoma, which may date as far back as the Byzantine period (300–600 AD), the epidemiology of the disease, which is characterized by an endemic region located between the latitudes of 15° south and 30° north, and the clinical presentation and treatment of mycetoma, focusing on the differences between eumycete and actinomycete infections. Diagnosis is established by identifying the type of grains found in the discharge, which guides treatment. Mycetoma caused by bacteria can usually be managed effectively with antibacterial medication alone, while infections with fungi require antifungal medication and surgery. Without proper treatment, mycetoma can lead to deformity, amputation, and death.
Literature
1.
go back to reference Ahmed AO, van Leeuwen W, Fahal A, et al. Mycetoma caused by Madurella mycetomatis: a neglected infectious burden. Lancet Infect Dis. 2004 Sep; 4 (9): 566–74PubMedCrossRef Ahmed AO, van Leeuwen W, Fahal A, et al. Mycetoma caused by Madurella mycetomatis: a neglected infectious burden. Lancet Infect Dis. 2004 Sep; 4 (9): 566–74PubMedCrossRef
2.
go back to reference Hay RJ. Deep fungal infections. In: Freedberg IM, Eisen AZ, Wolff K, et al., editors. Fitzpatrick’s dermatology in general medicine. 5th edition. Vol. 2. New York: McGraw-Hill; 1999: 2372–7 Hay RJ. Deep fungal infections. In: Freedberg IM, Eisen AZ, Wolff K, et al., editors. Fitzpatrick’s dermatology in general medicine. 5th edition. Vol. 2. New York: McGraw-Hill; 1999: 2372–7
4.
5.
go back to reference Hershkovitz I, Speirs M, Katznelson A, et al. Unusual pathological condition in the lower extremities of a skeleton from ancient Israel. Am J Phys Anthropol. 1992 May; 88 (1): 23–6PubMedCrossRef Hershkovitz I, Speirs M, Katznelson A, et al. Unusual pathological condition in the lower extremities of a skeleton from ancient Israel. Am J Phys Anthropol. 1992 May; 88 (1): 23–6PubMedCrossRef
6.
go back to reference Kwon-Chung KJ, Bennett JE. Mycetoma. In: Cann C, editor. Medical mycology. Malvern (PA): Lea & Febiger; 1992: 560–93 Kwon-Chung KJ, Bennett JE. Mycetoma. In: Cann C, editor. Medical mycology. Malvern (PA): Lea & Febiger; 1992: 560–93
7.
go back to reference Corre A. La maladie de Ballingall (pied du Maduré). Arch Med Nav. 1883; 39 (81): 204–24 Corre A. La maladie de Ballingall (pied du Maduré). Arch Med Nav. 1883; 39 (81): 204–24
8.
go back to reference Godfrey J. Diseases of the foot not hitherto described. Lancet. 1846; 1: 593–4 Godfrey J. Diseases of the foot not hitherto described. Lancet. 1846; 1: 593–4
9.
go back to reference Carter HV. On a new striking form of fungus disease principally affecting the foot and prevailing endemically in many parts of India. Trans Med Phys Soc Bombay. 1860; 60: 140–2 Carter HV. On a new striking form of fungus disease principally affecting the foot and prevailing endemically in many parts of India. Trans Med Phys Soc Bombay. 1860; 60: 140–2
10.
go back to reference Pinoy E. Actinomycoses and mycetomas. Bull Inst Past. 1913; 11: 929–38 Pinoy E. Actinomycoses and mycetomas. Bull Inst Past. 1913; 11: 929–38
12.
go back to reference Green WO, Adams TE. Mycetoma in the United States. Am J Clin Path. 1964 Jul; 42: 75–91PubMed Green WO, Adams TE. Mycetoma in the United States. Am J Clin Path. 1964 Jul; 42: 75–91PubMed
13.
go back to reference Tight RR, Bartlett MS. Actinomycetoma in the United States. Rev Infect Dis. 1981 Nov–Dec; 3 (6): 1139–50PubMedCrossRef Tight RR, Bartlett MS. Actinomycetoma in the United States. Rev Infect Dis. 1981 Nov–Dec; 3 (6): 1139–50PubMedCrossRef
14.
go back to reference Foltz KD, Fallat LM. Madura foot: atypical finding and case presentation. J Foot Ankle Surg. 2004 Sep–Oct; 43 (5): 327–31PubMedCrossRef Foltz KD, Fallat LM. Madura foot: atypical finding and case presentation. J Foot Ankle Surg. 2004 Sep–Oct; 43 (5): 327–31PubMedCrossRef
15.
go back to reference Rigopoulos D, Mavridou M, Nicolaidou E, et al. Mycetoma due to actinomycetes: a rare entity in Europe. Int J Dermatol. 2000 Jul; 39 (7): 557–8PubMedCrossRef Rigopoulos D, Mavridou M, Nicolaidou E, et al. Mycetoma due to actinomycetes: a rare entity in Europe. Int J Dermatol. 2000 Jul; 39 (7): 557–8PubMedCrossRef
16.
go back to reference De Palma L, Marinelli M, Pavan M, et al. A rare European case of Madura foot due to actinomycetes. Joint Bone Spine. 2006 May; 73 (3): 321PubMedCrossRef De Palma L, Marinelli M, Pavan M, et al. A rare European case of Madura foot due to actinomycetes. Joint Bone Spine. 2006 May; 73 (3): 321PubMedCrossRef
17.
go back to reference Lupi O, Tyring SK, McGinnis MR. Tropical dermatology: fungal tropical diseases. J Am Acad Dermatol. 2005 Dec; 53 (6): 931–51PubMedCrossRef Lupi O, Tyring SK, McGinnis MR. Tropical dermatology: fungal tropical diseases. J Am Acad Dermatol. 2005 Dec; 53 (6): 931–51PubMedCrossRef
18.
go back to reference Maiti PK, Ray A, Bandyopadhyay S. Epidemiological aspects of mycetoma from a retrospective study of 264 cases in West Bengal. Trop Med Int Health. 2002 Sep; 7 (9): 788–92PubMedCrossRef Maiti PK, Ray A, Bandyopadhyay S. Epidemiological aspects of mycetoma from a retrospective study of 264 cases in West Bengal. Trop Med Int Health. 2002 Sep; 7 (9): 788–92PubMedCrossRef
20.
go back to reference Khatri ML, Al-Halali HM, Fouad Khalid M. Mycetoma in Yemen: clinicoepidemiologic and histopathologic study. Int J Dermatol. 2002 Sep; 41 (9): 586–93PubMedCrossRef Khatri ML, Al-Halali HM, Fouad Khalid M. Mycetoma in Yemen: clinicoepidemiologic and histopathologic study. Int J Dermatol. 2002 Sep; 41 (9): 586–93PubMedCrossRef
22.
23.
go back to reference Sobera JO, Elewski BE. Mycetoma. In: Bolognia JL, Jorizzo JL, Rapini RP, et al., editors. Dermatology. Vol. 1. New York: Mosby, 2003: 1187–8 Sobera JO, Elewski BE. Mycetoma. In: Bolognia JL, Jorizzo JL, Rapini RP, et al., editors. Dermatology. Vol. 1. New York: Mosby, 2003: 1187–8
24.
go back to reference Verdolini R, Amerio P, Bugatti L, et al. Madura’s foot: report of a case caused by Madurella mycetomatis. Fur J Dermatol. 2000 Dec; 10 (8): 627–9 Verdolini R, Amerio P, Bugatti L, et al. Madura’s foot: report of a case caused by Madurella mycetomatis. Fur J Dermatol. 2000 Dec; 10 (8): 627–9
25.
go back to reference Turner PG. Madura foot or plantar fibromatosis. J Bone Joint Surg Br. 1989 May; 71 (3): 531PubMed Turner PG. Madura foot or plantar fibromatosis. J Bone Joint Surg Br. 1989 May; 71 (3): 531PubMed
26.
go back to reference Fahal AH, et Hassan AM, Abdelalla AO, et al. Cystic mycetoma: an unusual clinical presentation of Madurella mycetomatis infection. Trans R Soc Trop Med Hyg. 1998 Jan–Feb; 92 (1): 66–7PubMedCrossRef Fahal AH, et Hassan AM, Abdelalla AO, et al. Cystic mycetoma: an unusual clinical presentation of Madurella mycetomatis infection. Trans R Soc Trop Med Hyg. 1998 Jan–Feb; 92 (1): 66–7PubMedCrossRef
27.
go back to reference Richardson MD, Warnock DW. Mycetoma. In: Richardson MD, Warnock DW. Fungal infection diagnosis and management. 2nd ed. Malden (MA): Blackwell Science, Inc., 1997: 204–9 Richardson MD, Warnock DW. Mycetoma. In: Richardson MD, Warnock DW. Fungal infection diagnosis and management. 2nd ed. Malden (MA): Blackwell Science, Inc., 1997: 204–9
28.
go back to reference Boiron P, Locci R, Goodfellow M, et al. Nocardia, nocardiosis and mycetoma. Med Mycol. 1998; 36 Suppl. 1: 26–37PubMed Boiron P, Locci R, Goodfellow M, et al. Nocardia, nocardiosis and mycetoma. Med Mycol. 1998; 36 Suppl. 1: 26–37PubMed
30.
go back to reference Abd Bagi ME, Fahal AH, Sheik HE, et al. Pathological fractures in mycetoma. Trans R Soc Trop Med Hyg. 2003 Sep–Oct; 97 (5): 582–4PubMedCrossRef Abd Bagi ME, Fahal AH, Sheik HE, et al. Pathological fractures in mycetoma. Trans R Soc Trop Med Hyg. 2003 Sep–Oct; 97 (5): 582–4PubMedCrossRef
31.
go back to reference Sharif HS, Clark DC, Aabed MY, et al. Mycetoma: comparison of MR imaging with CT. Radiology. 1991 Mar; 178 (3): 865–70PubMed Sharif HS, Clark DC, Aabed MY, et al. Mycetoma: comparison of MR imaging with CT. Radiology. 1991 Mar; 178 (3): 865–70PubMed
32.
go back to reference Czechowski J, Nork H, Haas D, et al. MR and other imaging methods in the investigation of mycetomas. Acta Radiol. 2001 Jan; 42 (1): 24–6PubMedCrossRef Czechowski J, Nork H, Haas D, et al. MR and other imaging methods in the investigation of mycetomas. Acta Radiol. 2001 Jan; 42 (1): 24–6PubMedCrossRef
33.
go back to reference Yera H, Bougnox ME, Jeanrot C, et al. Mycetoma of the foot caused by Fusarium solani: identification of the etiologic agent by DNA sequencing. J Clin Microbiol. 2003 Apr; 41 (4): 1805–8PubMedCrossRef Yera H, Bougnox ME, Jeanrot C, et al. Mycetoma of the foot caused by Fusarium solani: identification of the etiologic agent by DNA sequencing. J Clin Microbiol. 2003 Apr; 41 (4): 1805–8PubMedCrossRef
34.
go back to reference Ahmed A, Adelmann D, Fahal A, et al. Environmental occurrence of Madurella mycetomatis, the major agent of human eumycetoma in Sudan. J Clin Microbiol. 2002 Mar; 40 (3): 1031–6PubMedCrossRef Ahmed A, Adelmann D, Fahal A, et al. Environmental occurrence of Madurella mycetomatis, the major agent of human eumycetoma in Sudan. J Clin Microbiol. 2002 Mar; 40 (3): 1031–6PubMedCrossRef
35.
go back to reference Mahgoub ES, Gumaa SA. Ketoconazole in the treatment of eumycetoma due to Madurella mycetoma. Trans R Soc Trop Med Hyg. 1984; 78 (3): 376–9PubMedCrossRef Mahgoub ES, Gumaa SA. Ketoconazole in the treatment of eumycetoma due to Madurella mycetoma. Trans R Soc Trop Med Hyg. 1984; 78 (3): 376–9PubMedCrossRef
36.
go back to reference Aiyenuro O, Nathan S. Mycetoma presenting as a painful ankle monoarthropathy: a case report. Foot Ankle Surg. 2006; 12: 43–6CrossRef Aiyenuro O, Nathan S. Mycetoma presenting as a painful ankle monoarthropathy: a case report. Foot Ankle Surg. 2006; 12: 43–6CrossRef
37.
go back to reference Mahgoub ES. Medical management of mycetoma. Bull World Health Organ. 1976; 54 (3): 303–10PubMed Mahgoub ES. Medical management of mycetoma. Bull World Health Organ. 1976; 54 (3): 303–10PubMed
38.
go back to reference Welsh O, Sauceda E, Gonzalez J, et al. Amikacin alone and in combination with trimethoprim-sulfamethoxazole in the treatment of actinomycotic mycetoma. J Am Acad Dermatol. 1987 Sep; 17 (3): 443–8PubMedCrossRef Welsh O, Sauceda E, Gonzalez J, et al. Amikacin alone and in combination with trimethoprim-sulfamethoxazole in the treatment of actinomycotic mycetoma. J Am Acad Dermatol. 1987 Sep; 17 (3): 443–8PubMedCrossRef
39.
go back to reference Kashima M, Kano R, Mikami Y, et al. A successfully treated case of mycetoma due to Nocardia veterana. Br J Dermatol. 2005 Jun; 152 (6): 1349–52PubMedCrossRef Kashima M, Kano R, Mikami Y, et al. A successfully treated case of mycetoma due to Nocardia veterana. Br J Dermatol. 2005 Jun; 152 (6): 1349–52PubMedCrossRef
40.
go back to reference Sharma N, Mendiratta V, Sharma RC, et al..Pulse therapy with amikacin and dapsone for the treatment of actinomycotic foot: a case report. J Dermatol. 2003 Oct; 30 (10): 742–7PubMed Sharma N, Mendiratta V, Sharma RC, et al..Pulse therapy with amikacin and dapsone for the treatment of actinomycotic foot: a case report. J Dermatol. 2003 Oct; 30 (10): 742–7PubMed
41.
go back to reference Fuentes A, Arenas R, Reyes M, et al..Actinomycetoma and Nocardia sp.: report of five cases treated with imipenem or imipenem plus amikacin [in Spanish]. Gac Med Mex. 2006 May–Jun; 142 (3): 247–52PubMed Fuentes A, Arenas R, Reyes M, et al..Actinomycetoma and Nocardia sp.: report of five cases treated with imipenem or imipenem plus amikacin [in Spanish]. Gac Med Mex. 2006 May–Jun; 142 (3): 247–52PubMed
42.
go back to reference Gomez A, Saul A, Bonifaz A, et al..Amoxicillin and clavulanic acid in the treatment of actinomycetes. Int J Dermatol. 1993 Mar; 32 (3): 218–20PubMedCrossRef Gomez A, Saul A, Bonifaz A, et al..Amoxicillin and clavulanic acid in the treatment of actinomycetes. Int J Dermatol. 1993 Mar; 32 (3): 218–20PubMedCrossRef
43.
go back to reference Ramam M, Garg T, D’Souza P, et al..A two-step schedule for the treatment of actinomycotic mycetomas. Acta Derm Venereol. 2000 Sep–Oct; 80 (5): 378–80PubMedCrossRef Ramam M, Garg T, D’Souza P, et al..A two-step schedule for the treatment of actinomycotic mycetomas. Acta Derm Venereol. 2000 Sep–Oct; 80 (5): 378–80PubMedCrossRef
Metadata
Title
Mycetoma
A Review
Authors
Vanessa Lichon
Dr Amor Khachemoune
Publication date
01-10-2006
Publisher
Springer International Publishing
Published in
American Journal of Clinical Dermatology / Issue 5/2006
Print ISSN: 1175-0561
Electronic ISSN: 1179-1888
DOI
https://doi.org/10.2165/00128071-200607050-00005

Other articles of this Issue 5/2006

American Journal of Clinical Dermatology 5/2006 Go to the issue