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01-02-2013 | Educational Series – Blue Series

MYC oncogene in myeloid neoplasias

Authors: M. Dolores Delgado, Marta Albajar, M. Teresa Gomez-Casares, Ana Batlle, Javier León

Published in: Clinical and Translational Oncology | Issue 2/2013

Abstract

MYC is a transcription factor that regulates many critical genes for cell proliferation, differentiation, and biomass accumulation. MYC is one of the most prevalent oncogenes found to be altered in human cancer, being deregulated in about 50 % of tumors. Although MYC deregulation has been more frequently associated to lymphoma and lymphoblastic leukemia than to myeloid malignancies, a body of evidence has been gathered showing that MYC plays a relevant role in malignancies derived from the myeloid compartment. The myeloid leukemogenic activity of MYC has been demonstrated in different murine models. Not surprisingly, MYC has been found to be amplified or/and deregulated in the three major types of myeloid neoplasms: acute myeloid leukemia, myelodysplastic syndromes, and myeloproliferative neoplasms, including chronic myeloid leukemia. Here, we review the recent literature describing the involvement of MYC in myeloid tumors.

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Title: MYC oncogene in myeloid neoplasias
Authors: M. Dolores Delgado
Marta Albajar
M. Teresa Gomez-Casares
Ana Batlle
Javier León
Publication date: 01-02-2013
Publisher: Springer Milan
Published in: Clinical and Translational Oncology / Issue 2/2013
Print ISSN: 1699-048X
Electronic ISSN: 1699-3055
DOI: https://doi.org/10.1007/s12094-012-0926-8

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