Published in:
Open Access
01-12-2006 | Research
Myb proteins inhibit fibroblast transformation by v-Rel
Authors:
Shu-ling Fu, Brigitte Ganter, Joseph S Lipsick
Published in:
Molecular Cancer
|
Issue 1/2006
Login to get access
Abstract
Genes that cause cancer have been divided into two general classes – oncogenes that act in a dominant fashion to transform normal cells into a malignant state, and tumor suppressor genes that act in a dominant fashion to prevent such transformation. In this report, we demonstrate that both the v-myb retroviral oncogene, which causes leukemic transformation of hematopoietic cells, and the c-myb proto-oncogene can also function as inhibitors of fibroblast transformation by the v-rel oncogene. These results imply that the myb genes can function either as oncogenes or as tumor suppressors in different cellular contexts.