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Neurological Sciences

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01-04-2022 | Myasthenia Gravis | Original Article

Serum irisin levels in patients with myasthenia gravis

Authors: Sheng-Nan Zhang, Qi Li, Qiu-Xia Zhang, Tian-Xiao Gao, Sheng-Hui Chang, Da-Qi Zhang, Lin-Jie Zhang, Li Yang

Published in: Neurological Sciences | Issue 4/2022

Abstract

Objective

Myasthenia gravis (MG) is an autoimmune disorder whose main symptoms are muscle weakness and fatigue. Irisin is a novel skeletal muscle–derived myokine participating in several physiological and pathological processes. The initial objective of the project was to explore serum levels of irisin in patients with MG, as well as its correlation with disease severity.

Methods

We retrospectively evaluated serum levels of irisin in 77 MG patients and 57 healthy controls (HCs) by enzyme-linked immunosorbent assay. Further, clinical parameters were measured properly.

Results

Serum irisin levels were significantly elevated in MG patients compared with HCs (p < 0.001). Furthermore, serum irisin levels were associated with the myasthenia gravis activities of daily living score in ocular myasthenia gravis (OMG) patients (r = 0.476, p = 0.004), but there was no relationship to be considered of any relevant value in generalized myasthenia gravis (GMG) patients. Acetylcholine receptor antibody–positive MG patients had higher serum irisin levels compared with HCs. Thymoma, endotracheal intubation, or intensive care unit treatments subsequently were not found to have effect on serum levels of irisin, but tendencies of increase were observed in negative ones.

Conclusions

Serum irisin levels were elevated in patients with MG, suggesting its possible involvement in MG. And irisin is expected to be a signal to evaluate the activities of daily living of OMG patients, while its effect needs further study.

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Title: Serum irisin levels in patients with myasthenia gravis
Authors: Sheng-Nan Zhang
Qi Li
Qiu-Xia Zhang
Tian-Xiao Gao
Sheng-Hui Chang
Da-Qi Zhang
Lin-Jie Zhang
Li Yang
Publication date: 01-04-2022
Publisher: Springer International Publishing
Keywords: Myasthenia Gravis
Thymoma
Thymoma
Published in: Neurological Sciences / Issue 4/2022
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-021-05652-x

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Serum irisin levels in patients with myasthenia gravis

Abstract

Objective

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Methods

Results

Conclusions

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