Published in:
01-10-2007 | Research Letter
Mutations in the SLC30A8 gene are not a major cause of MODY or other forms of early-onset, autosomal dominant type 2 diabetes
Authors:
M. Borowiec, R. Thompson, C. Powers, R. Xu, T. Dickey, A. Doria
Published in:
Diabetologia
|
Issue 10/2007
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Excerpt
To the Editor: MODY is a relatively rare type of familial diabetes that is characterised by a young age of onset and an autosomal dominant mode of inheritance. The availability of large families with multiple affected members has facilitated genetic studies of this syndrome and this has led to the identification of six distinct MODY genes [
1]. Several reports suggest that other MODY genes exist in addition to those identified to date [
1,
2]. In the UK, about 15% of MODY cases do not seem to result from mutations in known MODY genes [
2]. The proportion of unaccounted MODY is even higher if one uses a broader definition of the disease, one that takes into account the fact that MODY is often diagnosed after the traditional age limit of 25 years [
1]. …
