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Open Access 01-06-2018 | Correspondence

Mutations in LRRK2 amplify cell-to-cell protein aggregate propagation: a hypothesis

Author: Patrick A. Lewis

Published in: Acta Neuropathologica | Issue 6/2018

Excerpt

Mutations in the LRRK2 gene are the most common genetic cause of Parkinson’s disease (PD) [6]. Despite over a decade of research, the function of leucine-rich repeat kinase 2 (LRRK2), the multidomain, dual activity enzyme product of the LRRK2 gene, remains enigmatic—as does the nature of the dysfunction caused by mutations that leads to degeneration in the human brain. …

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Title: Mutations in LRRK2 amplify cell-to-cell protein aggregate propagation: a hypothesis
Author: Patrick A. Lewis
Publication date: 01-06-2018
Publisher: Springer Berlin Heidelberg
Published in: Acta Neuropathologica / Issue 6/2018
Print ISSN: 0001-6322
Electronic ISSN: 1432-0533
DOI: https://doi.org/10.1007/s00401-018-1838-7

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Mutations in LRRK2 amplify cell-to-cell protein aggregate propagation: a hypothesis

Excerpt

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Excerpt

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