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Published in: Aesthetic Plastic Surgery 4/2009

01-07-2009 | Original Article

Multistage Correction of Blepharophimosis: Our Rationale for 18 Cases

Authors: Huiyan Li, Dongmei Li, Ying Jie, Yin Qin

Published in: Aesthetic Plastic Surgery | Issue 4/2009

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Abstract

Background

Due to the complexity of staging order and the number of surgical procedures required to correct blepharophimosis-ptosis-epicanthus inversus (BPES), this study aimed to analyze multistage correction of BPES syndrome objectively.

Methods

This retrospective study was undertaken with 18 BPES patients who underwent multistage correction from April 2004 to September 2007. Data regarding levator function, horizontal palpebral fissure length (HPFL), vertical interpalpebral fissure height (IPFH), inner intercanthal distance (IICD), and the ratio of IICD to HPFL were recorded and analyzed. Facial photographs were taken both pre- and postoperatively. Any complications were documented.

Results

The Mustardé method was used for 13 patients, and the Y-to-V technique was selected for 5 patients. In addition, seven patients also received lateral canthoplasty. All the patients underwent frontalis aponeurosis suspension. Changes in both IICD and HPFL were statistically significant (P < 0.001). The IPFH also showed statistically significant improvement after surgery. The range in the preoperative ratio of IICD to HPFL was 1.48–2.35 (mean, 2.04 ± 0.28). Postoperatively, the ratios for all the patients were less than 1.8 (range, 1.1–1.5; mean, 1.28 ± 0.13). Changes in the ratio of IICD to HPFL were statistically significant (P < 0.001). Mild undercorrection was observed in two patients postoperatively. Although neither keratitis nor overcorrection occurred, conjunctiva prolapse was experienced by one patient 10 days after frontalis aponeurosis suspension.

Conclusion

Staged surgery for correction of BPES syndrome is beneficial in terms of improved function and cosmesis.
Literature
1.
go back to reference Nakajima T, Yoshimura Y, Onishi K, Sakakibara A (1991) One-stage repair of blepharophimosis. Plast Reconstr Surg 87:24–31PubMedCrossRef Nakajima T, Yoshimura Y, Onishi K, Sakakibara A (1991) One-stage repair of blepharophimosis. Plast Reconstr Surg 87:24–31PubMedCrossRef
2.
go back to reference Oley C, Baraitser M (1988) Blepharophimosis, ptosis, epicanthus inversus syndrome (BPES syndrome). J Med Genet 25:47–51PubMedCrossRef Oley C, Baraitser M (1988) Blepharophimosis, ptosis, epicanthus inversus syndrome (BPES syndrome). J Med Genet 25:47–51PubMedCrossRef
3.
go back to reference Zlotogora J, Sagi M, Cohen T (1983) The blepharophimosis, ptosis, and epicanthus inversus syndrome: delineation of two types. Am J Hum Genet 35:1020–1027PubMed Zlotogora J, Sagi M, Cohen T (1983) The blepharophimosis, ptosis, and epicanthus inversus syndrome: delineation of two types. Am J Hum Genet 35:1020–1027PubMed
4.
go back to reference Moumné L, Batista F, Benayoun BA, Nallathambi J, Fellous M, Sundaresan P, Veitia RA (2008) The mutations and potential targets of the forkhead transcription factor FOXL2. Mol Cell Endocrinol 282(1–2):2–11PubMedCrossRef Moumné L, Batista F, Benayoun BA, Nallathambi J, Fellous M, Sundaresan P, Veitia RA (2008) The mutations and potential targets of the forkhead transcription factor FOXL2. Mol Cell Endocrinol 282(1–2):2–11PubMedCrossRef
5.
go back to reference Tang SJ, Wang XK, Wang YL, Lin LX, Sun Y (2007) The mutation study of the FOXL2 gene in a big Chinese family with blepharophimosis-ptosis-epicanthus inversus syndrome. Zhonghua Zheng Xing Wai Ke Za Zhi 23:48–50 (in Chinese)PubMed Tang SJ, Wang XK, Wang YL, Lin LX, Sun Y (2007) The mutation study of the FOXL2 gene in a big Chinese family with blepharophimosis-ptosis-epicanthus inversus syndrome. Zhonghua Zheng Xing Wai Ke Za Zhi 23:48–50 (in Chinese)PubMed
6.
go back to reference Crisponi L, Deiana M, Loi A et al (2001) The putative forkhead transcription factor FOXL2 is mutated in blepharophimosis/ ptosis/epicanthus inversus syndrome. Nat Genet 27:159–166PubMedCrossRef Crisponi L, Deiana M, Loi A et al (2001) The putative forkhead transcription factor FOXL2 is mutated in blepharophimosis/ ptosis/epicanthus inversus syndrome. Nat Genet 27:159–166PubMedCrossRef
7.
go back to reference Taylor A, Strike PW, Tyers AG (2007) Blepharophimosis-ptosis-epicanthus inversus syndrome: objective analysis of surgical outcome in patients from a single unit. Clin Exp Ophthalmol 35:262–269CrossRef Taylor A, Strike PW, Tyers AG (2007) Blepharophimosis-ptosis-epicanthus inversus syndrome: objective analysis of surgical outcome in patients from a single unit. Clin Exp Ophthalmol 35:262–269CrossRef
8.
go back to reference Leon-Mateos A, Ginarte M, Ruiz-Ponte C, Carracedo A, Toribio J (2007) Blepharophimosis-ptosis-epicanthus inversus syndrome (BPES). Int J Dermatol 46:61–63PubMedCrossRef Leon-Mateos A, Ginarte M, Ruiz-Ponte C, Carracedo A, Toribio J (2007) Blepharophimosis-ptosis-epicanthus inversus syndrome (BPES). Int J Dermatol 46:61–63PubMedCrossRef
9.
go back to reference Wu SY, Ma L, Tsai YJ, Kuo JZ (2006) One-stage correction for blepharophimosis syndrome. Eye 17:1–9 Wu SY, Ma L, Tsai YJ, Kuo JZ (2006) One-stage correction for blepharophimosis syndrome. Eye 17:1–9
10.
go back to reference Karacaoglan N, Sahin U, Ercan U, Bozdogan N (1994) One-stage repair of blepharophimosis: a new method. Plast Reconstr Surg 93:1406–1409PubMedCrossRef Karacaoglan N, Sahin U, Ercan U, Bozdogan N (1994) One-stage repair of blepharophimosis: a new method. Plast Reconstr Surg 93:1406–1409PubMedCrossRef
11.
go back to reference Huang WQ, Qiao Q, Zhao R, Wang XJ, Fang XQ (2007) Surgical strategy for congenital blepharophimosis syndrome. Chin Med J (Engl) 120:1413–1415 Huang WQ, Qiao Q, Zhao R, Wang XJ, Fang XQ (2007) Surgical strategy for congenital blepharophimosis syndrome. Chin Med J (Engl) 120:1413–1415
12.
go back to reference Friedhofer H, Nigro MV, Filho AC, Ferreira MC (2006) Correction of blepharophimosis with silicone implant suspensor. Plast Reconstr Surg 117:1428–1434PubMedCrossRef Friedhofer H, Nigro MV, Filho AC, Ferreira MC (2006) Correction of blepharophimosis with silicone implant suspensor. Plast Reconstr Surg 117:1428–1434PubMedCrossRef
13.
go back to reference Beckingsale PS, Sullivan TJ, Wong VA, Oley C (2003) Blepharophimosis: a recommendation for early surgery in patients with severe ptosis. Clin Exp Ophthalmol 31:138–142CrossRef Beckingsale PS, Sullivan TJ, Wong VA, Oley C (2003) Blepharophimosis: a recommendation for early surgery in patients with severe ptosis. Clin Exp Ophthalmol 31:138–142CrossRef
14.
go back to reference Nowinski TS (1992) Correction of telecanthus in the blepharophimosis syndrome. Int Ophthalmol Clin 32:157–164PubMedCrossRef Nowinski TS (1992) Correction of telecanthus in the blepharophimosis syndrome. Int Ophthalmol Clin 32:157–164PubMedCrossRef
15.
go back to reference Yoon K (1993) Modification of Mustardé technique for correction of epicanthus in Asian patients. Plast Reconstr Surg 92:1182–1186PubMedCrossRef Yoon K (1993) Modification of Mustardé technique for correction of epicanthus in Asian patients. Plast Reconstr Surg 92:1182–1186PubMedCrossRef
16.
go back to reference Steinkogler FJ, Kuchar A, Huber E, Arocker-Mettinger E (1993) Gore-Tex soft-tissue patch frontalis suspension technique in congenital ptosis and in blepharophimosis-ptosis syndrome. Plast Reconstr Surg 92:1057–1060PubMedCrossRef Steinkogler FJ, Kuchar A, Huber E, Arocker-Mettinger E (1993) Gore-Tex soft-tissue patch frontalis suspension technique in congenital ptosis and in blepharophimosis-ptosis syndrome. Plast Reconstr Surg 92:1057–1060PubMedCrossRef
17.
go back to reference DeMartelaere SL, Blaydon SM, Cruz AA, Amato MM, Shore JW (2007) Broad fascia fixation enhances frontalis suspension. Ophthal Plast Reconstr Surg 23:279–284PubMedCrossRef DeMartelaere SL, Blaydon SM, Cruz AA, Amato MM, Shore JW (2007) Broad fascia fixation enhances frontalis suspension. Ophthal Plast Reconstr Surg 23:279–284PubMedCrossRef
18.
go back to reference Ibrahim HA (2007) Use of the levator muscle as a frontalis sling. Ophthal Plast Reconstr Surg 23:376–380PubMedCrossRef Ibrahim HA (2007) Use of the levator muscle as a frontalis sling. Ophthal Plast Reconstr Surg 23:376–380PubMedCrossRef
Metadata
Title
Multistage Correction of Blepharophimosis: Our Rationale for 18 Cases
Authors
Huiyan Li
Dongmei Li
Ying Jie
Yin Qin
Publication date
01-07-2009
Publisher
Springer-Verlag
Published in
Aesthetic Plastic Surgery / Issue 4/2009
Print ISSN: 0364-216X
Electronic ISSN: 1432-5241
DOI
https://doi.org/10.1007/s00266-009-9313-4

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