Multiple skeletal lesions on FDG PET in severe primary hyperparathyroidism

Excerpt

A 55-year-old man presented with weight loss and diffuse bone pain. Strongly elevated concentrations of calcium (3.49 mmol/L, with normoalbuminuria) and parathyroid hormone (260 pmol/L) indicated primary hyperparathyroidism.¹⁸F-FDG PET/CT scanning demonstrated uptake in the right upper and right lower pole of the thyroid region but also multiple ¹⁸F-FDG-avid osteolytic lesions, including the 7th cervical and 3rd lumbar vertebrae (a). Histopathological examination of a vertebral bone biopsy revealed a brown tumour. An enlarged left upper and right upper parathyroid gland were resected using a sestamibi gamma probe. In addition, a left-sided hemithyroidectomy with ipsilateral paratracheal nodal dissection was performed because of a suspected mass in the left thyroid lobe and enlarged lymph nodes [1]. Pathological examination demonstrated a parathyroid adenoma but no carcinoma. Postoperative recovery was complicated by a severe hungry bone syndrome. Repeat ¹⁸F-FDG PET/CT scanning 4 months after surgery showed a marked reduction in the number of ¹⁸F-FDG-avid lesions in the skeleton (b). Also the intensity of ¹⁸F-FDG uptake in the remaining lesions was significantly lower. …