Skip to main content
Top
Published in: Neurological Research and Practice 1/2021

01-12-2021 | Multiple Sclerosis | Review

Multiple sclerosis therapy consensus group (MSTCG): answers to the discussion questions

Authors: Heinz Wiendl, Ralf Gold, Frauke Zipp, for the Multiple Sclerosis Therapy Consensus Group

Published in: Neurological Research and Practice | Issue 1/2021

Login to get access

Excerpt

An explicit goal of multiple sclerosis (MS) therapy is the “best possible disease control”, including the “best possible quality of life” of the patient, with the option to use highly effective therapeutics early or as early as possible in response to disease activity. Specifically, the appropriate disease-modifying therapy (DMT) is selected based on the individual patient, and incorporates a situation and prognostic analysis that includes disease activity, disease severity, balancing therapy safety and risks, and considering the patient’s age, gender, and living situation. From the perspective of the MSTCG (Multiple Sclerosis Therapy Consensus Group) and supported by several large observational and registry studies, modern MS therapy can and should prevent the accumulation of disability and, thus, possible neurodegeneration. …
Appendix
Available only for authorised users
Literature
1.
go back to reference Chalmer, T. A., Baggesen, L. M., Nørgaard, M., Koch-Henriksen, N., Magyari, M., Sorensen, P. S., & the Danish Multiple Sclerosis Group & Danish multiple sclerosis group (2018). Early versus later treatment start in multiple sclerosis: A register-based cohort study. Eur J Neurol, 25(10), 1262–e110. https://doi.org/10.1111/ene.13692.CrossRefPubMed Chalmer, T. A., Baggesen, L. M., Nørgaard, M., Koch-Henriksen, N., Magyari, M., Sorensen, P. S., & the Danish Multiple Sclerosis Group & Danish multiple sclerosis group (2018). Early versus later treatment start in multiple sclerosis: A register-based cohort study. Eur J Neurol, 25(10), 1262–e110. https://​doi.​org/​10.​1111/​ene.​13692.CrossRefPubMed
2.
go back to reference He, A., Merkel, B., Brown, J. W. L., MSBase study group, et al. (2020). Timing of high-efficacy therapy for multiple sclerosis: A retrospective observational cohort study. Lancet Neurol, 19(4), 307–316.CrossRefPubMed He, A., Merkel, B., Brown, J. W. L., MSBase study group, et al. (2020). Timing of high-efficacy therapy for multiple sclerosis: A retrospective observational cohort study. Lancet Neurol, 19(4), 307–316.CrossRefPubMed
8.
go back to reference Rae-Grant, A., Day, G. S., Marrie, R. A., et al. (2018). Practice guideline recommendations summary: Disease-modifying therapies for adults with multiple sclerosis: Report of the guideline development, dissemination, and implementation Subcommittee of the American Academy of neurology. Neurology, 90(17), 777–788.CrossRefPubMed Rae-Grant, A., Day, G. S., Marrie, R. A., et al. (2018). Practice guideline recommendations summary: Disease-modifying therapies for adults with multiple sclerosis: Report of the guideline development, dissemination, and implementation Subcommittee of the American Academy of neurology. Neurology, 90(17), 777–788.CrossRefPubMed
12.
go back to reference Patti, F., Visconti, A., Capacchione, A., CLARINET-MS Study Group, et al. (2020). Long-term effectiveness in patients previously treated with cladribine tablets: a real-world analysis of the Italian multiple sclerosis registry (CLARINET-MS). Ther Adv Neurol Disord, 13, 1756286420922685.CrossRefPubMedPubMedCentral Patti, F., Visconti, A., Capacchione, A., CLARINET-MS Study Group, et al. (2020). Long-term effectiveness in patients previously treated with cladribine tablets: a real-world analysis of the Italian multiple sclerosis registry (CLARINET-MS). Ther Adv Neurol Disord, 13, 1756286420922685.CrossRefPubMedPubMedCentral
13.
go back to reference Kister, I., Spelman, T., Alroughani, R., Lechner-Scott, J., Duquette, P., Grand'Maison, F., … Butzkueven, H. (2016). Discontinuing disease-modifying therapy in MS after a prolonged relapse-free period: A propensity score-matched study. J Neurol Neurosurg Psychiatry, 87(10), 1133–1137. https://doi.org/10.1136/jnnp-2016-313760.CrossRefPubMed Kister, I., Spelman, T., Alroughani, R., Lechner-Scott, J., Duquette, P., Grand'Maison, F., … Butzkueven, H. (2016). Discontinuing disease-modifying therapy in MS after a prolonged relapse-free period: A propensity score-matched study. J Neurol Neurosurg Psychiatry, 87(10), 1133–1137. https://​doi.​org/​10.​1136/​jnnp-2016-313760.CrossRefPubMed
15.
go back to reference Pfeuffer S, Ruck T, Pul R, et al. Impact of previous disease-modifying treatment on effectiveness and safety outcomes, among patients with multiple sclerosis treated with alemtuzumab. J Neurol Neurosurg Psychiatr. https://doi.org/10.1136/jnnp-2020-325304. Epub ahead of print 12 March 2021. Pfeuffer S, Ruck T, Pul R, et al. Impact of previous disease-modifying treatment on effectiveness and safety outcomes, among patients with multiple sclerosis treated with alemtuzumab. J Neurol Neurosurg Psychiatr. https://​doi.​org/​10.​1136/​jnnp-2020-325304. Epub ahead of print 12 March 2021.
17.
go back to reference Prosperini, L., Kinkel, R. P., Miravalle, A. A., et al. (2019). Post-natalizumab disease reactivation in multiple sclerosis: Systematic review and meta-analysis. Ther Adv Neurol Disord, 12, 1756286419837809.CrossRefPubMedPubMedCentral Prosperini, L., Kinkel, R. P., Miravalle, A. A., et al. (2019). Post-natalizumab disease reactivation in multiple sclerosis: Systematic review and meta-analysis. Ther Adv Neurol Disord, 12, 1756286419837809.CrossRefPubMedPubMedCentral
18.
go back to reference Butzkueven H, Spelman T, Horakova D, et al. Risk of requiring a wheelchair in primary progressive multiple sclerosis: Data from the ORATORIO trial and the MSBase registry. Eur J Neurol. https://doi.org/10.1111/ene.14824. Epub ahead of print 16 March 2021. Butzkueven H, Spelman T, Horakova D, et al. Risk of requiring a wheelchair in primary progressive multiple sclerosis: Data from the ORATORIO trial and the MSBase registry. Eur J Neurol. https://​doi.​org/​10.​1111/​ene.​14824. Epub ahead of print 16 March 2021.
Metadata
Title
Multiple sclerosis therapy consensus group (MSTCG): answers to the discussion questions
Authors
Heinz Wiendl
Ralf Gold
Frauke Zipp
for the Multiple Sclerosis Therapy Consensus Group
Publication date
01-12-2021
Publisher
BioMed Central
Published in
Neurological Research and Practice / Issue 1/2021
Electronic ISSN: 2524-3489
DOI
https://doi.org/10.1186/s42466-021-00140-1

Other articles of this Issue 1/2021

Neurological Research and Practice 1/2021 Go to the issue