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The Egyptian Journal of Neurology, Psychiatry and Neurosurgery

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Open Access 01-12-2021 | Multiple Sclerosis | Research

Signs of neuroinflammation outweigh neurodegeneration as predictors for early conversion to MS

Authors: Nervana Mohamed El Fayomy, Hanan Helmy Mohamed, Manal Mohamed Kamal, Aya Hamid Alsayyad, Enas Hamid Alsayyad, Reham Mohamed Shamloul

Published in: The Egyptian Journal of Neurology, Psychiatry and Neurosurgery | Issue 1/2021

Abstract

Background

The pathophysiological mechanisms underlying multiple sclerosis include both inflammatory and degenerative processes. We aimed to study and compare markers of neuroinflammation and neurodegeneration in patients with first presentation of demyelinating disorder and to prospectively identify which of the studied markers serve as predictors for early conversion to multiple sclerosis. Thus, 42 patients with first clinical manifestations suggestive of demyelinating disease were included in a prospective study. Subjects underwent thorough history taking and clinical evaluation. Laboratory studies involved analysis of cerebrospinal fluid (CSF) and serum chitinase 3-like 1 levels. Brain imaging included MRI and ultrasonographic assessment.

Results

T1 black holes, elevated oligoclonal bands (OCB), high baseline T2 lesion load, and enhanced MRI lesions were significantly higher in patients with 1st attack multiple sclerosis. Significantly higher CSF-OCB and serum chitinase 3-like 1 protein was detected in patients with multiple sclerosis (MS) compared to clinically isolated syndrome, and higher levels in MS convertors than non-convertors. Cognitive dysfunction evaluated by MoCA test and brain atrophy assessed using transcranial sonography did not show significant difference among the studied groups. Logistic regression analysis showed that heavy T2 lesion load served as the only predictor of conversion to MS.

Conclusion

Early conversion to MS after first attack of demyelination is related to detection of signs of neuroinflammation rather than neurodegeneration.

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Title: Signs of neuroinflammation outweigh neurodegeneration as predictors for early conversion to MS
Authors: Nervana Mohamed El Fayomy
Hanan Helmy Mohamed
Manal Mohamed Kamal
Aya Hamid Alsayyad
Enas Hamid Alsayyad
Reham Mohamed Shamloul
Publication date: 01-12-2021
Publisher: Springer Berlin Heidelberg
Keywords: Multiple Sclerosis
Magnetic Resonance Imaging
Magnetic Resonance Imaging
Published in: The Egyptian Journal of Neurology, Psychiatry and Neurosurgery / Issue 1/2021
Electronic ISSN: 1687-8329
DOI: https://doi.org/10.1186/s41983-021-00356-7

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Signs of neuroinflammation outweigh neurodegeneration as predictors for early conversion to MS

Abstract

Background

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Results

Conclusion

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