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01-10-2020 | Multiple Sclerosis | Original Communication

Impaired speed-dependent modulation of the gait pattern in multiple sclerosis

Authors: David Weller, Linard Filli, Christian Meyer, Lilla Lörincz, Michael Linnebank, Michael Weller, Armin Curt, Björn Zörner

Published in: Journal of Neurology | Issue 10/2020

Abstract

Background

Walking dysfunction is common in people with multiple sclerosis (MS). Besides walking speed or endurance, one crucial feature of ambulatory function is the ability to adjust the gait pattern according to walking speed which relies on the integrity of spinal motor centres, their reciprocal connections to supraspinal networks and peripheral sensory input.

Objective

To investigate the capacity of people with MS to modify their gait pattern in response to changes in walking speed.

Methods

3D gait analysis during free treadmill walking was performed in 35 people with MS and 20 healthy controls. Twelve kinematic parameters ranging from basic spatiotemporal measures to complex indicators of intralimb coordination were assessed at different absolute and relative walking speeds.

Results

Cadence, double-limb support time, trunk movements and especially measures of intralimb coordination demonstrated significantly less speed-dependent modifications in MS than in controls. These limitations were more prominent in subjects with stronger MS-related impairment (worse outcome in clinical walking tests, higher Expanded Disability Status Scale).

Conclusion

The incapacity to modify specific elements of the walking pattern according to walking speed contributes to gait dysfunction in people with MS limiting activities of daily living. Gait modulation may serve as sensitive marker of walking function in MS.

Trial registration

Clinicaltrials.gov, NCT01576354; first posted April 12, 2012.

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Title: Impaired speed-dependent modulation of the gait pattern in multiple sclerosis
Authors: David Weller
Linard Filli
Christian Meyer
Lilla Lörincz
Michael Linnebank
Michael Weller
Armin Curt
Björn Zörner
Publication date: 01-10-2020
Publisher: Springer Berlin Heidelberg
Keyword: Multiple Sclerosis
Published in: Journal of Neurology / Issue 10/2020
Print ISSN: 0340-5354
Electronic ISSN: 1432-1459
DOI: https://doi.org/10.1007/s00415-020-09965-3

At a glance: The STEP trials

Springer Medicine

Impaired speed-dependent modulation of the gait pattern in multiple sclerosis

Abstract

Background

Objective

Methods

Results

Conclusion

Trial registration

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Objective

Methods

Results

Conclusion

Trial registration

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