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BMC Neurology

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Open Access 01-12-2023 | Multiple Sclerosis | Research

The effect of fatigue on postural control in individuals with multiple sclerosis: a systematic review

Authors: Parisa Sedaghati, Mohammad Alghosi, Freshteh Hosseini

Published in: BMC Neurology | Issue 1/2023

Abstract

Background

Fatigue is the most disabling symptom for individuals with multiple sclerosis (MS), which can significantly affect postural control (PC) by impairing the ability of the central nervous system to modulate sensory inputs and coordinate motor responses. This systematic review aimed to investigate the effect of fatigue on PC in individuals with MS..

Methods

This systematic review is reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline and registered in PROSPERO with ID CRD42022376262. A systematic search was performed in the Web of Science, PubMed, Scopus, and Google Scholar until January 2023, and a manual search was performed using the reference lists of included studies. Two authors independently selected the studies, extracted data, and evaluated their methodological quality using the Downs and Black checklist. The process was later discussed with a third author..

Results

Five studies were included in this review, of which consistent evidence investigating a direct relationship between fatigue and PC in individuals with MS. All the studies reported negative effects on PC. Four studies employed walking tests as their primary protocol for inducing fatigue, while one study implemented a strength testing protocol for both legs, serving as a fatigue-inducing activity.

Conclusions

The evidence suggests that individuals with MS may experience PC deficits due to fatigue. However, the present body of literature exhibits limitations regarding its quality and methodology. Gender differences, balance, fatigue task, and muscle function are essential factors that need to be considered when investigating the relationship between fatigue and PC deficits in MS. Further high-quality research is necessary to comprehend the complex interplay between MS-related fatigue and PC deficits after physical activity.

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Title: The effect of fatigue on postural control in individuals with multiple sclerosis: a systematic review
Authors: Parisa Sedaghati
Mohammad Alghosi
Freshteh Hosseini
Publication date: 01-12-2023
Publisher: BioMed Central
Keywords: Multiple Sclerosis
Fatigue
Published in: BMC Neurology / Issue 1/2023
Electronic ISSN: 1471-2377
DOI: https://doi.org/10.1186/s12883-023-03464-4

Keynote webinar | Spotlight on medication adherence

Springer Medicine

The effect of fatigue on postural control in individuals with multiple sclerosis: a systematic review

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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