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01-09-2019 | Multiple Sclerosis | Brief Communication

Cycle ergometer training enhances plasma interleukin-10 in multiple sclerosis

Published in: Neurological Sciences | Issue 9/2019

Abstract

The objective was to determine plasma levels of pro- (IL-12p70/IL-6) and anti-inflammatory (IL-10) cytokines before and after cycle ergometer training in healthy control (HC) and people with multiple sclerosis (pwMS), and to correlate plasma cytokines with physical/mental health. Study participants cycled for 30 min at 65–75% age-predicted maximal heart rate, twice a week for 8 weeks during supervised sessions. We determined that plasma IL-10 expression was lower in pwMS, compared to HCs, and that exercise augmented IL-10 in pwMS to baseline levels in HCs. Furthermore, plasma isolated from pwMS displayed enhanced expression of the pro-inflammatory cytokines IL-12p70/IL-6. Plasma cytokine signatures correlated with physical/mental health. Overall, this study highlights the potential of a short-term exercise programme to regulate circulating cytokine profiles with relevance to pwMS.

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Title: Cycle ergometer training enhances plasma interleukin-10 in multiple sclerosis
Publication date: 01-09-2019
Keywords: Multiple Sclerosis
Cytokines
Published in: Neurological Sciences / Issue 9/2019
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-019-03915-2

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Springer Medicine

Cycle ergometer training enhances plasma interleukin-10 in multiple sclerosis

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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