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International Journal of Computer Assisted Radiology and Surgery

Published in:

01-11-2020 | Original Article

Multiple objective planning for thermal ablation of liver tumors

Authors: Libin Liang, Derek Cool, Nirmal Kakani, Guangzhi Wang, Hui Ding, Aaron Fenster

Published in: International Journal of Computer Assisted Radiology and Surgery | Issue 11/2020

Abstract

Purpose

Preoperative treatment planning is key to ensure successful thermal ablation of liver tumors. The planning aims to minimize the number of electrodes required for complete ablation and the damage to the surrounding tissues while satisfying multiple clinical constraints. This is a challenging multiple objective planning problem, in which the trade-off between different objectives must be considered.

Methods

We propose a novel method to solve the multiple objective planning problem, which combines the set cover-based model and Pareto optimization. The set cover-based model considers multiple clinical constraints and generates several clinically feasible treatment plans, among which the Pareto optimization is performed to find the trade-off between different objectives.

Results

We evaluated the proposed method on 20 tumors of 11 patients in two different situations used in common thermal ablation approaches: with and without the pull-back technique. Pareto optimal plans were found and verified to be clinically acceptable in all cases, which can find the trade-off between the number of electrodes and the damage to the surrounding tissues.

Conclusion

The proposed method performs well in the two different situations we considered: with or without the pull-back technique. It can generate Pareto optimal plans satisfying multiple clinical constraints. These plans consider the trade-off between different planning objectives.

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Title: Multiple objective planning for thermal ablation of liver tumors
Authors: Libin Liang
Derek Cool
Nirmal Kakani
Guangzhi Wang
Hui Ding
Aaron Fenster
Publication date: 01-11-2020
Publisher: Springer International Publishing
Published in: International Journal of Computer Assisted Radiology and Surgery / Issue 11/2020
Print ISSN: 1861-6410
Electronic ISSN: 1861-6429
DOI: https://doi.org/10.1007/s11548-020-02252-6

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Multiple objective planning for thermal ablation of liver tumors

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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