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Journal of Hematology & Oncology
Published in: Journal of Hematology & Oncology 1/2019

Open Access 01-12-2019 | Multiple Myeloma | Review

Chimeric antigen receptor T cell therapies for multiple myeloma

Authors: Chao Wu, Lina Zhang, Qierra R. Brockman, Fenghuang Zhan, Lijuan Chen

Published in: Journal of Hematology & Oncology | Issue 1/2019

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Abstract

Multiple myeloma (MM) is the second most common hematologic malignancy and remains incurable despite the advent of numerous new drugs such as proteasome inhibitors (PIs), immunomodulatory agents (IMiDs), and monoclonal antibodies. There is an unmet need to develop novel therapies for refractory/relapsed MM. In the past few years, chimeric antigen receptor (CAR)-modified T cell therapy for MM has shown promising efficacy in preclinical and clinical studies. Furthermore, the toxicities of CAR-T cell therapy are manageable. This article summarizes recent developments of CAR-T therapy in MM, focusing on promising targets, new technologies, and new research areas. Additionally, a comprehensive overview of antigen selection is presented along with preliminary results and future directions of CAR-T therapy development.
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Metadata
Title
Chimeric antigen receptor T cell therapies for multiple myeloma
Authors
Chao Wu
Lina Zhang
Qierra R. Brockman
Fenghuang Zhan
Lijuan Chen
Publication date
01-12-2019
Publisher
BioMed Central
Published in
Journal of Hematology & Oncology / Issue 1/2019
Electronic ISSN: 1756-8722
DOI
https://doi.org/10.1186/s13045-019-0823-5

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