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Journal of Hematology & Oncology
Published in: Journal of Hematology & Oncology 1/2018

Open Access 01-12-2018 | Review

Multiple functions of m6A RNA methylation in cancer

Authors: Yutian Pan, Pei Ma, Yu Liu, Wei Li, Yongqian Shu

Published in: Journal of Hematology & Oncology | Issue 1/2018

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Abstract

First identified in 1974, m6A RNA methylation, which serves as a predominant internal modification of RNA in higher eukaryotes, has gained prodigious interest in recent years. Modifications of m6A are dynamic and reversible in mammalian cells, which have been proposed as another layer of epigenetic regulation similar to DNA and histone modifications. m6A RNA methylation is involved in all stages in the life cycle of RNA, ranging from RNA processing, through nuclear export, translation modulation to RNA degradation, which suggests its potential of influencing a plurality of aspects of RNA metabolism. All of the recent studies have pointed to a complicated regulation network of m6A modification in different tissues, cell lines, and space–time models. m6A methylation has been found to have an impact on tumor initiation and progression through various mechanisms. Furthermore, m6A RNA methylation has provided new opportunities for early stage diagnosis and treatment of cancers.
Herein, we review the chemical basis of m6A RNA methylation, its multiple functions and potential significance in cancer.
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Metadata
Title
Multiple functions of m6A RNA methylation in cancer
Authors
Yutian Pan
Pei Ma
Yu Liu
Wei Li
Yongqian Shu
Publication date
01-12-2018
Publisher
BioMed Central
Published in
Journal of Hematology & Oncology / Issue 1/2018
Electronic ISSN: 1756-8722
DOI
https://doi.org/10.1186/s13045-018-0590-8

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