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01-03-2012 | Review Article

Multimodal MRI of Experimental Stroke

Author: Timothy Q. Duong

Published in: Translational Stroke Research | Issue 1/2012

Abstract

Stroke is the fourth leading cause of death and the leading cause of long-term disability in USA. Brain imaging data from experimental stroke models and stroke patients have shown that there is often a gradual progression of potentially reversible ischemic injury toward infarction. Reestablishing tissue perfusion and/or treating with neuroprotective drugs in a timely fashion are expected to salvage some ischemic tissues. Diffusion-weighted imaging based on magnetic resonance imaging (MRI) in which contrast is based on water motion can detect ischemic injury within minutes after onsets, whereas computed tomography and other imaging modalities fail to detect stroke injury for at least a few hours. Along with quantitative perfusion imaging, the perfusion–diffusion mismatch which approximates the ischemic penumbra could be imaged noninvasively. This review describes recent progresses in the development and application of multimodal MRI and image analysis techniques to study ischemic tissue at risk in experimental stroke in rats.

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Title: Multimodal MRI of Experimental Stroke
Author: Timothy Q. Duong
Publication date: 01-03-2012
Publisher: Springer-Verlag
Published in: Translational Stroke Research / Issue 1/2012
Print ISSN: 1868-4483
Electronic ISSN: 1868-601X
DOI: https://doi.org/10.1007/s12975-011-0140-y

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Multimodal MRI of Experimental Stroke

Abstract

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