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Reproductive Biology and Endocrinology
Published in: Reproductive Biology and Endocrinology 1/2008

Open Access 01-12-2008 | Research

Multilevel model to assess sources of variation in follicular growth close to the time of ovulation in women with normal fertility: a multicenter observational study

Authors: Rafael T Mikolajczyk, Joseph B Stanford, René Ecochard

Published in: Reproductive Biology and Endocrinology | Issue 1/2008

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Abstract

Background

To assess the amount of variability in ovarian follicular growth rate and maximum follicular diameter related to different centers, women and cycles of the same women in a multicenter observational study of follicular growth.

Methods

Secondary analysis of a prospective cohort study from eight centers in Europe. There were 533 ultrasound examinations in 282 cycles of 107 women with normal fertility. A random effects model with center, woman and cycle as hierarchical units of variation was used to analyze mean follicular diameter on days preceding ovulation.

Results

Follicular growth did not differ by center. There was homogenous growth across women and cycles, and the maximum follicular diameter before ovulation varied substantially across cycles but not across women. Many (about 40%) women had small maximum follicular diameter on the day before ovulation (<19 mm). Pre-ovulatory cycle length was not related to maximum follicular diameter.

Conclusion

In normal fecundity, there is a substantial variation in maximum follicular diameter from cycle to cycle based on variation in the duration of follicular development, but the variation could not be explained by different characteristics of different women. Explanation of variation in follicular growth has to be found on the cycle level.
Appendix
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Metadata
Title
Multilevel model to assess sources of variation in follicular growth close to the time of ovulation in women with normal fertility: a multicenter observational study
Authors
Rafael T Mikolajczyk
Joseph B Stanford
René Ecochard
Publication date
01-12-2008
Publisher
BioMed Central
Published in
Reproductive Biology and Endocrinology / Issue 1/2008
Electronic ISSN: 1477-7827
DOI
https://doi.org/10.1186/1477-7827-6-61

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