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Clinical Neuroradiology
Published in: Clinical Neuroradiology 2/2018

01-06-2018 | Correspondence

Multicentric Chordoma

An Uncommon and Incompletely Understood Presentation

Authors: Jason R. Jones, Anita Huttner, Ajay Malhotra

Published in: Clinical Neuroradiology | Issue 2/2018

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Excerpt

Chordoma is a rare neoplasm of the neuraxis, long believed to arise from notochord remnants. Its distribution has principally thought to favor the sacrococcygeal region, followed by the skull base and then elsewhere discretely along the spine. Although recent data may challenge this pattern, even more infrequently chordomas are seen arising simultaneously at multiple points along the neuraxis [1]. Very few cases of multicentric chordoma have been reported. A more diffuse pattern complicates treatment strategies for this slowly growing, locally recurrent neoplasm that has historically not responded well to chemotherapy. Recent efforts have sought to better explain the inciting variables that lead to this disease and further efforts will hopefully clarify the cause for the exceedingly rare, diffuse presentation, as well as new molecularly based treatment strategies. …
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Metadata
Title
Multicentric Chordoma
An Uncommon and Incompletely Understood Presentation
Authors
Jason R. Jones
Anita Huttner
Ajay Malhotra
Publication date
01-06-2018
Publisher
Springer Berlin Heidelberg
Published in
Clinical Neuroradiology / Issue 2/2018
Print ISSN: 1869-1439
Electronic ISSN: 1869-1447
DOI
https://doi.org/10.1007/s00062-017-0610-z

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