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01-01-2009 | original article

Multiagent Chemotherapy for Isolated Colorectal Liver Metastases: A Single-centered Retrospective Study

Authors: Srinevas K. Reddy, Gloria Broadwater, Donna Niedzwiecki, Andrew S. Barbas, Herbert I. Hurwitz, Johanna C. Bendell, Michael A. Morse, Bryan M. Clary

Published in: Journal of Gastrointestinal Surgery | Issue 1/2009

Abstract

Background

Few studies identifying variables associated with prognosis after resection of colorectal liver metastases (CLM) account for treatment with multiagent chemotherapy (fluoropyrmidines with irinotecan, oxaliplatin, bevacizumab, and/or cetuximab). The objective of this retrospective study was to determine the effect of multiagent chemotherapy on long-term survival after resection of CLM.

Methods

Demographics, clinicopathologic tumor characteristics, treatments, and long-term outcomes were reviewed.

Results

From 1996 to 2006, 230 patients underwent resection of CLM. Treatment strategies before and after resection included fluoropyrimidine monotherapy (n = 34 and n = 39), multiagent chemotherapy (n = 81 and n = 73), and observation (n = 115 and n = 118). Prehepatectomy treatment strategy was not associated with overall survival. Actuarial 4-year survival was 63%, 39%, and 40% for patients treated with multiagent chemotherapy, fluoropyrimidine monotherapy, and observation after hepatectomy, p = 0.06. Posthepatectomy multiagent chemotherapy (p = 0.04, HR 0.52 [0.27–1.03]), duration of posthepatectomy chemotherapy treatment of 2 months or longer (p = 0.05, HR 0.49 [0.25–0.99]), carcino-embryonic antigen level >10 ng/mL (p = 0.03, HR 2.09, 95% CI [1.32–3.32]), and node positive primary tumor (p = 0.002, HR 1.79 [1.06–3.02]) were associated with overall survival in multivariate analysis.

Conclusions

The association of posthepatectomy multiagent chemotherapy with overall survival in this retrospective study indicates the need for prospective randomized trials comparing multiagent chemotherapy and fluoropyrimidine monotherapy for CLM.

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Title: Multiagent Chemotherapy for Isolated Colorectal Liver Metastases: A Single-centered Retrospective Study
Authors: Srinevas K. Reddy
Gloria Broadwater
Donna Niedzwiecki
Andrew S. Barbas
Herbert I. Hurwitz
Johanna C. Bendell
Michael A. Morse
Bryan M. Clary
Publication date: 01-01-2009
Publisher: Springer-Verlag
Published in: Journal of Gastrointestinal Surgery / Issue 1/2009
Print ISSN: 1091-255X
Electronic ISSN: 1873-4626
DOI: https://doi.org/10.1007/s11605-008-0617-5

2024 ASCO Annual Meeting

Springer Medicine

Multiagent Chemotherapy for Isolated Colorectal Liver Metastases: A Single-centered Retrospective Study

Abstract

Background

Methods

Results

Conclusions

2024 ASCO Annual Meeting

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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